JPS58997A - ビタミンｂ↓１↓２の検定法およびその検定用のラベル付き誘導体 - Google Patents
ビタミンｂ↓１↓２の検定法およびその検定用のラベル付き誘導体Info
- Publication number
- JPS58997A JPS58997A JP57106294A JP10629482A JPS58997A JP S58997 A JPS58997 A JP S58997A JP 57106294 A JP57106294 A JP 57106294A JP 10629482 A JP10629482 A JP 10629482A JP S58997 A JPS58997 A JP S58997A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- labeled
- group
- derivative
- label
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000007689 inspection Methods 0.000 title 1
- 229940045999 vitamin b 12 Drugs 0.000 title 1
- 238000000034 method Methods 0.000 claims description 16
- 150000002763 monocarboxylic acids Chemical class 0.000 claims description 14
- 238000003556 assay Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- 102000014914 Carrier Proteins Human genes 0.000 claims description 8
- 108091008324 binding proteins Proteins 0.000 claims description 8
- 229930003231 vitamin Natural products 0.000 claims description 8
- 235000013343 vitamin Nutrition 0.000 claims description 8
- 239000011782 vitamin Substances 0.000 claims description 8
- 229940088594 vitamin Drugs 0.000 claims description 8
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 235000019156 vitamin B Nutrition 0.000 claims description 7
- 239000011720 vitamin B Substances 0.000 claims description 7
- 229930003270 Vitamin B Natural products 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 125000004429 atom Chemical group 0.000 claims description 5
- 229940029329 intrinsic factor Drugs 0.000 claims description 5
- 230000002285 radioactive effect Effects 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 238000012875 competitive assay Methods 0.000 claims description 4
- 230000009137 competitive binding Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 125000005907 alkyl ester group Chemical group 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 239000004020 conductor Substances 0.000 claims description 3
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims description 2
- BXRMEWOQUXOLDH-LURJTMIESA-N L-Histidine methyl ester Chemical compound COC(=O)[C@@H](N)CC1=CN=CN1 BXRMEWOQUXOLDH-LURJTMIESA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 238000005903 acid hydrolysis reaction Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 7
- 238000009739 binding Methods 0.000 description 7
- 230000027455 binding Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 229960001340 histamine Drugs 0.000 description 4
- MWZPENIJLUWBSY-VIFPVBQESA-N methyl L-tyrosinate Chemical compound COC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWZPENIJLUWBSY-VIFPVBQESA-N 0.000 description 4
- 239000000700 radioactive tracer Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 101000658547 Escherichia coli (strain K12) Type I restriction enzyme EcoKI endonuclease subunit Proteins 0.000 description 3
- 101000658543 Escherichia coli Type I restriction enzyme EcoAI endonuclease subunit Proteins 0.000 description 3
- 101000658546 Escherichia coli Type I restriction enzyme EcoEI endonuclease subunit Proteins 0.000 description 3
- 101000658530 Escherichia coli Type I restriction enzyme EcoR124II endonuclease subunit Proteins 0.000 description 3
- 101000658540 Escherichia coli Type I restriction enzyme EcoprrI endonuclease subunit Proteins 0.000 description 3
- 101000658545 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Type I restriction enyme HindI endonuclease subunit Proteins 0.000 description 3
- 101000658548 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaIXP endonuclease subunit Proteins 0.000 description 3
- 101000658542 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIIP endonuclease subunit Proteins 0.000 description 3
- 101000658529 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIP endonuclease subunit Proteins 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 101001042773 Staphylococcus aureus (strain COL) Type I restriction enzyme SauCOLORF180P endonuclease subunit Proteins 0.000 description 3
- 101000838760 Staphylococcus aureus (strain MRSA252) Type I restriction enzyme SauMRSORF196P endonuclease subunit Proteins 0.000 description 3
- 101000838761 Staphylococcus aureus (strain MSSA476) Type I restriction enzyme SauMSSORF170P endonuclease subunit Proteins 0.000 description 3
- 101000838758 Staphylococcus aureus (strain MW2) Type I restriction enzyme SauMW2ORF169P endonuclease subunit Proteins 0.000 description 3
- 101001042566 Staphylococcus aureus (strain Mu50 / ATCC 700699) Type I restriction enzyme SauMu50ORF195P endonuclease subunit Proteins 0.000 description 3
- 101000838763 Staphylococcus aureus (strain N315) Type I restriction enzyme SauN315I endonuclease subunit Proteins 0.000 description 3
- 101000838759 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) Type I restriction enzyme SepRPIP endonuclease subunit Proteins 0.000 description 3
- 101000838756 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) Type I restriction enzyme SsaAORF53P endonuclease subunit Proteins 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 239000011630 iodine Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 2
- 125000002843 carboxylic acid group Chemical group 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- VANNPISTIUFMLH-UHFFFAOYSA-N glutaric anhydride Chemical compound O=C1CCCC(=O)O1 VANNPISTIUFMLH-UHFFFAOYSA-N 0.000 description 2
- 230000009871 nonspecific binding Effects 0.000 description 2
- 238000004816 paper chromatography Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- -1 (bJ Chemical class 0.000 description 1
- VWLAGVVQCMHHJW-UHFFFAOYSA-N 1-(2-aminoethyl)-3-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)thiourea Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C21OC(=O)C1=CC(NC(=S)NCCN)=CC=C21 VWLAGVVQCMHHJW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000270281 Coluber constrictor Species 0.000 description 1
- 229910020674 Co—B Inorganic materials 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 101000874160 Homo sapiens Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229930003761 Vitamin B9 Natural products 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- OQZCSNDVOWYALR-UHFFFAOYSA-N flurochloridone Chemical compound FC(F)(F)C1=CC=CC(N2C(C(Cl)C(CCl)C2)=O)=C1 OQZCSNDVOWYALR-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 102000045360 human SDHB Human genes 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002083 iodinating effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 235000019159 vitamin B9 Nutrition 0.000 description 1
- 239000011727 vitamin B9 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8119147 | 1981-06-22 | ||
| GB8119147 | 1981-06-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58997A true JPS58997A (ja) | 1983-01-06 |
| JPH0553378B2 JPH0553378B2 (https=) | 1993-08-09 |
Family
ID=10522711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57106294A Granted JPS58997A (ja) | 1981-06-22 | 1982-06-22 | ビタミンｂ↓１↓２の検定法およびその検定用のラベル付き誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4465775A (https=) |
| EP (1) | EP0069450B1 (https=) |
| JP (1) | JPS58997A (https=) |
| CA (1) | CA1180273A (https=) |
| DE (1) | DE3262956D1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04363659A (ja) * | 1991-06-10 | 1992-12-16 | Smithkline Beckman Corp | ビタミンｂ１２の分析 |
| JP2003528041A (ja) * | 1999-10-26 | 2003-09-24 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | 蛍光性コバラミンおよびその使用 |
| JP2007515457A (ja) * | 2003-12-22 | 2007-06-14 | ソリダゴ・アーゲー | 異常な細胞の増殖の診断および治療に有効なコバラミン誘導体 |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ217821A (en) * | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
| US5807832A (en) * | 1987-06-09 | 1998-09-15 | Biotech Australia Pty Limited | Oral delivery of biologically active substances bound to vitamin B12 |
| JPH03500003U (https=) * | 1988-06-15 | 1991-06-06 | ||
| US4925931A (en) * | 1988-07-14 | 1990-05-15 | Mccully Kilmer S | N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof |
| DE3900648A1 (de) * | 1989-01-11 | 1990-07-12 | Boehringer Mannheim Gmbh | Neue cobalamin-saeurehydrazide und davon abgeleitete cobalamin-konjugate |
| US5405839A (en) * | 1989-02-28 | 1995-04-11 | Teijin Limited | Vitamin B12 derivative, preparation process thereof, and use thereof |
| WO1990010014A1 (fr) * | 1989-02-28 | 1990-09-07 | Teijin Limited | Nouveau derive de vitamine b12, sa production et son application |
| US5310656A (en) * | 1989-06-26 | 1994-05-10 | Tritech Partners | Vitamin B12 assay |
| US5506109A (en) * | 1989-06-26 | 1996-04-09 | Bayer Corporation | Vitamin B12 assay |
| CA1335707C (en) * | 1989-08-15 | 1995-05-30 | Pyare Khanna | Drug screening assay |
| CA2084194C (en) * | 1991-04-02 | 2003-05-20 | Gregory John Russell-Jones | Oral delivery systems for microparticles |
| US6942977B1 (en) | 1991-04-09 | 2005-09-13 | Bio-Rad Laboratories, Inc. | Immunoassays for determining vitamin b12, and reagents and kits therefor |
| CA2187346C (en) * | 1994-04-08 | 2010-06-29 | A. Charles Morgan, Jr. | Receptor modulating agents and methods relating thereto |
| US5739287A (en) * | 1994-04-08 | 1998-04-14 | University Of Washington | Biotinylated cobalamins |
| US5840880A (en) * | 1994-04-08 | 1998-11-24 | Receptagen Corporation | Receptor modulating agents |
| US6769128B1 (en) | 1995-06-07 | 2004-07-27 | United Video Properties, Inc. | Electronic television program guide schedule system and method with data feed access |
| US5739313A (en) | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
| WO1999004561A1 (en) | 1997-07-21 | 1999-01-28 | E-Guide, Inc. | Systems and methods for displaying and recording control interfaces |
| CN1867068A (zh) | 1998-07-14 | 2006-11-22 | 联合视频制品公司 | 交互式电视节目导视系统及其方法 |
| US6898762B2 (en) | 1998-08-21 | 2005-05-24 | United Video Properties, Inc. | Client-server electronic program guide |
| GB9820473D0 (en) * | 1998-09-18 | 1998-11-11 | Axis Biochemicals Asa | Assay |
| US20010051346A1 (en) * | 1998-09-18 | 2001-12-13 | Erling Sundrehagen | Assay |
| US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| WO2001028595A1 (en) | 1999-10-15 | 2001-04-26 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
| US7591995B2 (en) | 1999-10-15 | 2009-09-22 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
| JP2003512338A (ja) * | 1999-10-15 | 2003-04-02 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 造影剤および抗腫瘍薬として有用なコバラミン結合体 |
| US6797521B2 (en) | 1999-10-26 | 2004-09-28 | University Of Utah Research Foundation | Fluorescent cobalamins and uses thereof |
| CA2427146A1 (en) | 2000-10-25 | 2002-07-18 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| KR20090104922A (ko) | 2001-02-21 | 2009-10-06 | 유나이티드 비디오 프로퍼티즈, 인크. | 개인용 비디오 녹화 특징을 갖는 대화식 프로그램 가이드를 위한 시스템 및 방법 |
| CA2441146C (en) * | 2001-03-16 | 2011-08-09 | University Of Utah Research Foundation | Fluorescent cobalamins and uses thereof |
| US20030018009A1 (en) * | 2001-06-20 | 2003-01-23 | Collins Douglas A. | Adenosyl-cobalamin fortified compositions |
| US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
| JP2005508332A (ja) * | 2001-09-28 | 2005-03-31 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与 |
| KR100440725B1 (ko) * | 2002-06-20 | 2004-07-15 | 주식회사 그린진 바이오텍 | 비생물성 스트레스에 대한 단자엽 식물의 내성을증가시키는 방법 |
| US8535750B2 (en) * | 2005-05-17 | 2013-09-17 | Cargill, Incorporated | Granular lecithins, granular lysolecithins, process for their production and compositions containing them |
| US8140141B2 (en) * | 2006-05-17 | 2012-03-20 | University Of Utah Research Foundation | Devices and methods for fluorescent inspection and/or removal of material in a sample |
| US8989561B1 (en) | 2008-05-29 | 2015-03-24 | Rovi Guides, Inc. | Systems and methods for alerting users of the postponed recording of programs |
| US9120858B2 (en) | 2011-07-22 | 2015-09-01 | The Research Foundation Of State University Of New York | Antibodies to the B12-transcobalamin receptor |
| US8805418B2 (en) | 2011-12-23 | 2014-08-12 | United Video Properties, Inc. | Methods and systems for performing actions based on location-based rules |
| GB202018713D0 (en) * | 2020-11-27 | 2021-01-13 | Quadram Inst Bioscience | Methods and compositions utilising vitamin b12 binding |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54157600A (en) * | 1978-05-30 | 1979-12-12 | Squibb & Sons Inc | Vitamin b 12 derivative and its manufacture |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR5372M (https=) * | 1966-02-10 | 1967-10-16 | ||
| US3989812A (en) * | 1974-08-09 | 1976-11-02 | Smithkline Instruments, Inc. | Folic acid derivatives and use in radio-assay |
| US3937799A (en) * | 1974-08-26 | 1976-02-10 | Bio-Rad Laboratories | Radioassay of vitamin b-12 employing bentonite |
| US3981863A (en) * | 1975-02-25 | 1976-09-21 | Micromedic Diagonistics, Inc. | Cyanocobalamin derivatives |
| US4336185A (en) * | 1976-03-02 | 1982-06-22 | Rohm And Haas Company | Folic acid derivatives |
| US4276280A (en) * | 1976-09-29 | 1981-06-30 | Becton, Dickinson And Company | Radiolabeled derivatives of folic acid |
| US4298735A (en) * | 1979-04-30 | 1981-11-03 | Union Carbide Corporation | Folic acid derivatives |
-
1982
- 1982-05-18 CA CA000403150A patent/CA1180273A/en not_active Expired
- 1982-05-18 EP EP82302523A patent/EP0069450B1/en not_active Expired
- 1982-05-18 DE DE8282302523T patent/DE3262956D1/de not_active Expired
- 1982-05-24 US US06/381,267 patent/US4465775A/en not_active Expired - Fee Related
- 1982-06-22 JP JP57106294A patent/JPS58997A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54157600A (en) * | 1978-05-30 | 1979-12-12 | Squibb & Sons Inc | Vitamin b 12 derivative and its manufacture |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04363659A (ja) * | 1991-06-10 | 1992-12-16 | Smithkline Beckman Corp | ビタミンｂ１２の分析 |
| JP2003528041A (ja) * | 1999-10-26 | 2003-09-24 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | 蛍光性コバラミンおよびその使用 |
| JP2007515457A (ja) * | 2003-12-22 | 2007-06-14 | ソリダゴ・アーゲー | 異常な細胞の増殖の診断および治療に有効なコバラミン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3262956D1 (en) | 1985-05-15 |
| EP0069450B1 (en) | 1985-04-10 |
| JPH0553378B2 (https=) | 1993-08-09 |
| CA1180273A (en) | 1985-01-02 |
| US4465775A (en) | 1984-08-14 |
| EP0069450A1 (en) | 1983-01-12 |
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