JPS5855485A - グアニンの精製法 - Google Patents
グアニンの精製法Info
- Publication number
- JPS5855485A JPS5855485A JP15215581A JP15215581A JPS5855485A JP S5855485 A JPS5855485 A JP S5855485A JP 15215581 A JP15215581 A JP 15215581A JP 15215581 A JP15215581 A JP 15215581A JP S5855485 A JPS5855485 A JP S5855485A
- Authority
- JP
- Japan
- Prior art keywords
- guanine
- aqueous solution
- alkali
- crude
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title claims abstract description 91
- 238000000746 purification Methods 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 20
- 239000007864 aqueous solution Substances 0.000 claims abstract description 14
- 239000003513 alkali Substances 0.000 claims abstract description 6
- 239000012535 impurity Substances 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 4
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910001854 alkali hydroxide Inorganic materials 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract description 9
- 239000000243 solution Substances 0.000 abstract description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract description 6
- 239000002904 solvent Substances 0.000 abstract description 6
- 238000001816 cooling Methods 0.000 abstract description 4
- 238000010438 heat treatment Methods 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 3
- 239000003463 adsorbent Substances 0.000 abstract description 2
- 239000007769 metal material Substances 0.000 abstract description 2
- 238000001953 recrystallisation Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 description 9
- 230000008025 crystallization Effects 0.000 description 9
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000013078 crystal Substances 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 150000004675 formic acid derivatives Chemical class 0.000 description 2
- 238000004811 liquid chromatography Methods 0.000 description 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-IGMARMGPSA-N Carbon-12 Chemical class [12C] OKTJSMMVPCPJKN-IGMARMGPSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910000564 Raney nickel Inorganic materials 0.000 description 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- -1 guanine salt Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15215581A JPS5855485A (ja) | 1981-09-28 | 1981-09-28 | グアニンの精製法 |
| GB08227127A GB2109369B (en) | 1981-09-28 | 1982-09-23 | Process for purifying guanine |
| DE19823235372 DE3235372A1 (de) | 1981-09-28 | 1982-09-24 | Verfahren zur reinigung von guanin |
| CH565682A CH651834A5 (de) | 1981-09-28 | 1982-09-24 | Verfahren zur reinigung von guanin. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15215581A JPS5855485A (ja) | 1981-09-28 | 1981-09-28 | グアニンの精製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5855485A true JPS5855485A (ja) | 1983-04-01 |
Family
ID=15534220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15215581A Pending JPS5855485A (ja) | 1981-09-28 | 1981-09-28 | グアニンの精製法 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5855485A (enrdf_load_stackoverflow) |
| CH (1) | CH651834A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3235372A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2109369B (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3727508A1 (de) * | 1987-08-18 | 1989-03-02 | Boehringer Ingelheim Kg | Verfahren zur herstellung von natriumpurinen |
| DE3729471A1 (de) * | 1987-09-03 | 1989-03-16 | Huels Troisdorf | Verfahren zur herstellung von guanin |
| US6207650B1 (en) * | 1989-05-15 | 2001-03-27 | Bristol-Myers Squibb Company | Antiviral, highly water soluble, stable, crystalline salts of 2′, 3′-dideoxyinosine, 2′, 3′-dideoxy-2′, 3′-didehydrothymidine and 2′, 3′-dideoxy-2′-fluoroinosine |
| DE3928365A1 (de) * | 1989-08-28 | 1991-03-07 | Huels Chemische Werke Ag | Verfahren zur herstellung von reinem guanin |
| DE4022314A1 (de) * | 1990-07-13 | 1992-01-16 | Boehringer Ingelheim Kg | Verfahren zur herstellung von 2-chlor-1,7-dihydropurin-6-on und verfahren zu dessen reinigung |
| DE4136114C2 (de) * | 1991-11-02 | 1995-05-24 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von Guanin und seiner Alkalimetallsalze |
| DE4422587C2 (de) * | 1994-06-28 | 2000-11-30 | Sueddeutsche Kalkstickstoff | Verfahren zur Herstellung von Purinen |
-
1981
- 1981-09-28 JP JP15215581A patent/JPS5855485A/ja active Pending
-
1982
- 1982-09-23 GB GB08227127A patent/GB2109369B/en not_active Expired
- 1982-09-24 CH CH565682A patent/CH651834A5/de not_active IP Right Cessation
- 1982-09-24 DE DE19823235372 patent/DE3235372A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH651834A5 (de) | 1985-10-15 |
| GB2109369A (en) | 1983-06-02 |
| GB2109369B (en) | 1985-06-12 |
| DE3235372A1 (de) | 1983-04-14 |
| DE3235372C2 (enrdf_load_stackoverflow) | 1990-09-06 |
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