JPS58194819A - 胃腸での薬剤吸収を促進する薬剤としてのα−ケトアルデヒド - Google Patents

胃腸での薬剤吸収を促進する薬剤としてのα−ケトアルデヒド

Info

Publication number
JPS58194819A
JPS58194819A JP58072330A JP7233083A JPS58194819A JP S58194819 A JPS58194819 A JP S58194819A JP 58072330 A JP58072330 A JP 58072330A JP 7233083 A JP7233083 A JP 7233083A JP S58194819 A JPS58194819 A JP S58194819A
Authority
JP
Japan
Prior art keywords
drug
agent
item
adjuvant
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58072330A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6352015B2 (https=
Inventor
ジヨセフ・エ−・フイクス
ステフアノ・エ−・ポガニ−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS58194819A publication Critical patent/JPS58194819A/ja
Publication of JPS6352015B2 publication Critical patent/JPS6352015B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP58072330A 1982-04-26 1983-04-26 胃腸での薬剤吸収を促進する薬剤としてのα−ケトアルデヒド Granted JPS58194819A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US371873 1982-04-26
US06/371,873 US4440740A (en) 1982-04-26 1982-04-26 α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption

Publications (2)

Publication Number Publication Date
JPS58194819A true JPS58194819A (ja) 1983-11-12
JPS6352015B2 JPS6352015B2 (https=) 1988-10-17

Family

ID=23465753

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58072330A Granted JPS58194819A (ja) 1982-04-26 1983-04-26 胃腸での薬剤吸収を促進する薬剤としてのα−ケトアルデヒド

Country Status (2)

Country Link
US (1) US4440740A (https=)
JP (1) JPS58194819A (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007971A1 (fr) * 1989-11-29 1991-06-13 Nippon Shinyaku Co., Ltd. Composition administree par voie rectale

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US4732915A (en) * 1983-11-02 1988-03-22 Alza Corporation Process for increasing solubility of drug
US4639458A (en) * 1985-01-22 1987-01-27 Merck & Co., Inc. Tablet and formulation
US5008288A (en) * 1986-01-06 1991-04-16 Alfred Stracher Carnitine directed pharmaceutical agents
US4866040A (en) * 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
US4983400A (en) * 1986-06-16 1991-01-08 Merck & Co., Inc. Controlled release combination of carbidopa/levodopa
ZA889189B (en) * 1986-06-16 1989-08-30 Merck & Co Inc Controlled release combination of carbidopa/levodopa
US4832957A (en) * 1987-12-11 1989-05-23 Merck & Co., Inc. Controlled release combination of carbidopa/levodopa
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4871731A (en) * 1987-10-07 1989-10-03 Marion Laboratories, Inc. Captopril and diltiazem composition and the like
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
US5849783A (en) * 1990-07-03 1998-12-15 Cell Research Corporation Autobiotics and their use in eliminating nonself cells
US5147652A (en) * 1990-07-03 1992-09-15 Cell Research Corporation Autobiotics and their use in eliminating nonself cells in vivo
DE10031043A1 (de) * 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US20050009762A1 (en) * 2003-06-06 2005-01-13 Strobel Michael Albert Application of water and organic solvent soluble ivermectin for topical and oral use
US6627613B2 (en) 2001-07-23 2003-09-30 Michael A. Strobel Application of water and organic solvent soluble ivermectin for topical and oral use
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
JP5046219B2 (ja) * 2002-10-31 2012-10-10 リガンド・ファーマシューティカルズ・インコーポレイテッド １，３−プロパン−１−アリールジオールの新規環状リン酸ジエステルおよびそのプロドラッグへの使用
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20060088588A1 (en) * 2004-10-21 2006-04-27 Lourdes Pila-Collazo Medication administering device and system
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
CN108658876A (zh) 2012-12-17 2018-10-16 帕里昂科学公司 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
CA2895512C (en) 2012-12-17 2021-10-19 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
JP2017512183A (ja) 2014-02-13 2017-05-18 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
RU2020126177A (ru) 2018-01-09 2022-02-10 Лиганд Фармасьютикалз, Инк. Ацетальные соединения и их терапевтическое применение
US11638714B2 (en) 2020-11-10 2023-05-02 Mountain Valley Md Inc Water dissolvable macrocyclic lactone cyclodextrin complexes
US11077134B1 (en) 2020-11-10 2021-08-03 Mountain Valley Md Inc Water dissolvable macrocyclic lactone cyclodextrin complexes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007971A1 (fr) * 1989-11-29 1991-06-13 Nippon Shinyaku Co., Ltd. Composition administree par voie rectale

Also Published As

Publication number Publication date
JPS6352015B2 (https=) 1988-10-17
US4440740A (en) 1984-04-03

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