JPS58184540A - 生化学センサ及び生化学センサを用いた化合物濃度の測定方法 - Google Patents
生化学センサ及び生化学センサを用いた化合物濃度の測定方法Info
- Publication number
- JPS58184540A JPS58184540A JP57066981A JP6698182A JPS58184540A JP S58184540 A JPS58184540 A JP S58184540A JP 57066981 A JP57066981 A JP 57066981A JP 6698182 A JP6698182 A JP 6698182A JP S58184540 A JPS58184540 A JP S58184540A
- Authority
- JP
- Japan
- Prior art keywords
- biochemical
- isfet
- immobilized
- ion
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims description 10
- 239000012528 membrane Substances 0.000 claims abstract description 24
- 239000000126 substance Substances 0.000 claims abstract description 19
- 230000005669 field effect Effects 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims 1
- 108010015776 Glucose oxidase Proteins 0.000 abstract description 7
- 239000004366 Glucose oxidase Substances 0.000 abstract description 7
- 229940116332 glucose oxidase Drugs 0.000 abstract description 7
- 235000019420 glucose oxidase Nutrition 0.000 abstract description 7
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 abstract description 5
- 230000003100 immobilizing effect Effects 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 description 26
- 239000000243 solution Substances 0.000 description 20
- 238000001514 detection method Methods 0.000 description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 235000006693 Cassia laevigata Nutrition 0.000 description 3
- 241000522641 Senna Species 0.000 description 3
- 229910052581 Si3N4 Inorganic materials 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 229940124513 senna glycoside Drugs 0.000 description 3
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- -1 hydrogen ions Chemical class 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 description 1
- 241001026509 Kata Species 0.000 description 1
- 241000270322 Lepidosauria Species 0.000 description 1
- XLIJUKVKOIMPKW-BTVCFUMJSA-N [O].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O Chemical compound [O].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O XLIJUKVKOIMPKW-BTVCFUMJSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229940075397 calomel Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- GTKRFUAGOKINCA-UHFFFAOYSA-M chlorosilver;silver Chemical compound [Ag].[Ag]Cl GTKRFUAGOKINCA-UHFFFAOYSA-M 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57066981A JPS58184540A (ja) | 1982-04-21 | 1982-04-21 | 生化学センサ及び生化学センサを用いた化合物濃度の測定方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57066981A JPS58184540A (ja) | 1982-04-21 | 1982-04-21 | 生化学センサ及び生化学センサを用いた化合物濃度の測定方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58184540A true JPS58184540A (ja) | 1983-10-28 |
| JPH037066B2 JPH037066B2 (enrdf_load_stackoverflow) | 1991-01-31 |
Family
ID=13331699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57066981A Granted JPS58184540A (ja) | 1982-04-21 | 1982-04-21 | 生化学センサ及び生化学センサを用いた化合物濃度の測定方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58184540A (enrdf_load_stackoverflow) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6029657A (ja) * | 1983-07-28 | 1985-02-15 | Mitsubishi Electric Corp | グルコースセンサの製造方法 |
| JPS6279334A (ja) * | 1985-09-09 | 1987-04-11 | オルド，インコ−ポレ−テツド | 螢光免疫検定装置及び方法 |
| JPS62130349A (ja) * | 1985-11-22 | 1987-06-12 | ソーン イーエムアイ ピーエルシー | 溶液中の物質の濃度を測定する装置 |
| JPS62502061A (ja) * | 1985-01-14 | 1987-08-13 | センサ− ダイアグナステイツクス インコ−ポレ−テツド | バルク導電率を用いた配位子／反配位子の相互干渉の測定 |
| JPS63111454A (ja) * | 1986-10-29 | 1988-05-16 | Nec Corp | 固定化酵素膜の製造方法 |
| JPH02280047A (ja) * | 1989-04-21 | 1990-11-16 | Nec Corp | １チップ半導体バイオセンサ |
| JPH04254750A (ja) * | 1990-08-21 | 1992-09-10 | Byung Ki Sohn | 感イオン電界効果トランジスタを利用するバイオセンサー用測定回路 |
| EP1392860A4 (en) * | 2001-04-23 | 2006-11-29 | Samsung Electronics Co Ltd | MOLECULAR DETECTION CHIP COMPRISING A MOSFET TRANSISTOR, MOLECULAR DETECTION DEVICE USING THE SAME, AND MOLECULAR DETECTION METHOD USING THE SAME |
| JP2015099070A (ja) * | 2013-11-19 | 2015-05-28 | 大日本印刷株式会社 | 溶液内蔵バイオセンサ |
-
1982
- 1982-04-21 JP JP57066981A patent/JPS58184540A/ja active Granted
Non-Patent Citations (1)
| Title |
|---|
| ANALYTICAL CHEMISTRY=1980 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6029657A (ja) * | 1983-07-28 | 1985-02-15 | Mitsubishi Electric Corp | グルコースセンサの製造方法 |
| JPS62502061A (ja) * | 1985-01-14 | 1987-08-13 | センサ− ダイアグナステイツクス インコ−ポレ−テツド | バルク導電率を用いた配位子／反配位子の相互干渉の測定 |
| JPS6279334A (ja) * | 1985-09-09 | 1987-04-11 | オルド，インコ−ポレ−テツド | 螢光免疫検定装置及び方法 |
| JPS62130349A (ja) * | 1985-11-22 | 1987-06-12 | ソーン イーエムアイ ピーエルシー | 溶液中の物質の濃度を測定する装置 |
| JPS63111454A (ja) * | 1986-10-29 | 1988-05-16 | Nec Corp | 固定化酵素膜の製造方法 |
| JPH02280047A (ja) * | 1989-04-21 | 1990-11-16 | Nec Corp | １チップ半導体バイオセンサ |
| JPH04254750A (ja) * | 1990-08-21 | 1992-09-10 | Byung Ki Sohn | 感イオン電界効果トランジスタを利用するバイオセンサー用測定回路 |
| EP1392860A4 (en) * | 2001-04-23 | 2006-11-29 | Samsung Electronics Co Ltd | MOLECULAR DETECTION CHIP COMPRISING A MOSFET TRANSISTOR, MOLECULAR DETECTION DEVICE USING THE SAME, AND MOLECULAR DETECTION METHOD USING THE SAME |
| US7781167B2 (en) | 2001-04-23 | 2010-08-24 | Samsung Electronics Co., Ltd. | Molecular detection methods using molecular detection chips including a metal oxide semiconductor field effect transistor |
| US7863140B2 (en) | 2001-04-23 | 2011-01-04 | Samsung Electronics Co., Ltd. | Methods of making a molecular detection chip having a metal oxide silicon field effect transistor on sidewalls of a micro-fluid channel |
| JP2015099070A (ja) * | 2013-11-19 | 2015-05-28 | 大日本印刷株式会社 | 溶液内蔵バイオセンサ |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH037066B2 (enrdf_load_stackoverflow) | 1991-01-31 |
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