JPS58159749A - Polishing of tablet and polishing agent scattering apparatus - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for polishing tablets and a device for dispersing polishing agent-9. The present invention relates to a method for polishing tablets, which can uniformly spread a polishing agent over tablets, and therefore can polish the tablets extremely effectively, and a polishing agent dispersing device used therein.

Coated tablets such as sugar-coated tablets and film tablets are not shiny and do not slip easily unless they are polished.
Troubles may occur during the next sorting process or printing process, or during the packaging process. Therefore, polishing is an important process that cannot be removed.

Conventional methods for polishing tablets include a method in which a polishing agent such as wax is dissolved in an organic solvent. However, since this method uses organic solvents, it is unfavorable from a safety and health perspective, so in recent years, many methods have been used to perform polishing using powdered polishing agents (for example, JP-A-Sho). 53-52618).

In the polishing method using a powder polishing agent, the polishing process is usually performed by a worker or by manually scattering the powder polishing agent directly onto the child's tablet. However, in this case, depending on the method of dispersing the polishing agent, a lump of the polishing agent may appear on the tablet surface, or the polishing agent may appear in the stamped area of a film tablet that has been stamped and film-coated. When the agent enters the product, the stamp disappears and the product loses its value. Regarding sugar-coated tablets, if a clump of polishing agent such as wax forms on the surface of the sugar coating, there is a risk that the wax may be transferred to the dedine roll and cause clogging of the dedine roll when the code number is printed in the subsequent printing process. There is. Therefore, once the tablets become clogged, a large number of printing defects will occur thereafter. Particularly if clogging occurs at the beginning of printing, all subsequent tablets will be defective, which is a big problem. Therefore, it is necessary to avoid the formation of agglomerates of the polishing agent on sugar-coated tablets, even for just one tablet.

Another method of spraying powdered polish is to put it in a cloth bag and spray it, but if the mesh of the cloth is large, it can be sprayed quickly, but as with the direct spraying mentioned above, There is a drawback that the polishing agent clumps on the tablet, and if the cloth mesh is small, the polishing agent does not come out easily and takes time.

The object of the present invention is to solve the above-mentioned problems in the conventional powder polishing agent dispersion, and to be able to uniformly distribute the powder polishing agent on the tablets, so that no agglomeration of the polishing agent occurs on the tablets. According to the present invention, in order to achieve the above object,
By blowing the powdered polish by pressurized air through a relatively fine-mesh filter through an aperture opening,
A method for polishing tablets is provided, which comprises scattering the powder polishing agent onto tablets to polish the tablets.

Further, according to the present invention, in order to carry out the above method, a container containing a powder polishing agent, a diaphragm opening provided at the tip of the container, and a filter with a relatively fine mesh provided in the diaphragm opening are provided. There is provided a polishing agent dispersing device characterized in that the polishing agent dispersing device comprises: and a pressure feeding means for spraying the powdered polishing agent in the container from the aperture opening through the filter using pressurized air.

In the polishing agent dispersing device of the present invention, the filter preferably has a mesh size of about 20 to 200 meshes. If the mesh of the filter becomes smaller than this, it becomes difficult for the powder polishing agent to come out from the aperture opening.
Also, if the mesh size of the filter becomes larger than this,
There is a risk that a sufficient sieving effect by the filter may not be obtained and the powder polishing agent may clump on the tablet.

In the polishing agent dispersing device described above, the area ratio of the aperture opening to the cross-sectional area of the container is approximately 1/10.000.
It is preferable that it is 1/2.7.

If the area ratio becomes smaller than this, the powder polishing agent will not come out from the aperture opening, and if the area ratio becomes larger than this, the jetting force of pressurized air will become weaker, and the powder polishing agent will not be sufficiently atomized. cannot be converted into More preferably, the area ratio of the aperture opening to the cross-sectional area of the container is about 1/204 to 1/69, and in this range H the best atomization of the powder polish is obtained.

In the above-mentioned spraying method and spraying device of the present invention, the polishing agent may be, for example, carnauba wax alone, a mixture of carnauba wax and talc, a mixture of carnauba wax and magnesium stearate, or a mixture of carnauba wax, talc, and stearic acid. can be done, but
It is also possible to use any other polishing agent that can be turned into a powder at room temperature.

In this specification, the term "powder layer" means that fine powder particles are dispersed in a mist.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Examples of a polishing agent dispersing device used in the tablet polishing method of the present invention will be described below with reference to the drawings.

In FIG. 1, the entire polishing agent dispersing device is designated by the reference numeral 2, and the dispersing device 2 has a cylindrical container 4 for containing the powder polishing agent. A diaphragm aperture 6 is provided, and the diaphragm aperture 6 is provided with a filter 8 having a relatively fine mesh as shown in FIG. The spraying device 2 also has a pressure feeding means 10 for discharging from the throttle opening 6 through the container 8, and in the illustrated embodiment, the pressure feeding means 10 is a piston device that reciprocates within the cylindrical container 4. This piston device is manually operated by an operator by means of a rod 20.

To use this dispersion device 2, first, the pressure feeding means, ie, the piston device 10, is removed from the cylindrical container 4, a suitable amount of powder polishing agent is put into the container 4, and the air inside the container is compressed by the piston device 10. As a result, the air inside the container 4 is forced into the aperture opening 6
Therefore, the powder polishing agent is also ejected from the aperture opening 6 through the filter 8. Therefore filter 8
The sieved powder polish is well layered and evenly distributed over the tablets. Therefore, it is possible to prevent the polishing agent from smearing on the tablet.

The cylindrical container 4 of the dispensing device 2 can be constructed of two halves 16.18 which are integrally engaged with each other by screws 12.14, as shown in FIG. By doing this, it is possible to prevent the piston 10 from being damaged early due to removing and inserting the piston device 10 from the container every time the powder polishing agent is put into the container 4. .

Further, in the illustrated embodiment, the piston device 10 is a manual type operated by the rod 20, but the piston 10 can be operated by connecting the rod 20 to an appropriate drive source. It is also possible to perform this by mechanical force or the like.

Further, in the illustrated embodiment, the pressure feeding means 10 is a piston device, but the present invention is not limited to this, and the container 4 may be connected to a pressurized air source through a valve of a conduit, and pressurized air may be sent to the container 4 by operating a bulge. It is also possible for the powder polish in the container 4 to be ejected through the throttle opening 6.

As a result of experiments, it has been found that the mesh size of the filter 8 provided in the diaphragm opening 6 in the spraying device 2 is preferably in the range of approximately 20 to 20.0 meshes. If the mesh of the filter becomes smaller than this, it will be difficult for the powder polishing agent to come out, and if it becomes larger than this, the powder polishing agent will not be able to pass through the sieve sufficiently, and there is a risk that the polishing agent will clump on the tablet. comes out.

It has also been found that in order to obtain a sufficient jetting effect from the throttle opening 6, it is preferable that the area A of the throttle opening 6 be within a predetermined area ratio with respect to the cross-sectional area B of the container 4.

Table 1 below shows the results of experiments conducted in this regard. In this experiment, the inner diameter of the container 4 was kept constant at 100 m, and the hole diameter of the aperture opening 6 was varied. I saw the condition. The filter 8 used had a mesh size of 100 meshes. -Table 1 The best powder layering of the powder polish was obtained within the range 1/204 to 1/69. In the area ratio A/B of 1/204 or less, a usable powder layer was obtained up to an area ratio of 1/10.000, but if the area ratio was smaller than that, the powder polishing agent would not come out. Although it became worse and was not suitable for practical use, in the range where the area ratio A/B is larger than 1/69, it becomes 1/
Almost usable powder layering was obtained up to an area ratio of 2.7.
When the area ratio was larger than that, the ejection force became smaller and sufficient powder layering could not be obtained.

Next, an embodiment of the polishing method of the present invention using the polishing agent dispersing device described above will be described.

Example 1 While a film tablet was placed in a coating pot and rotated, carnauba wax was put into the spraying device of the present invention and sprayed onto the film tablet to polish it. The spraying device used had a filter with a mesh size of 200 mesh and an area ratio of the aperture opening to the cross-sectional area of the container of 1151. The film tablet is a 100 square inch/tablet film tablet in which a code number is stamped on a bare tablet and then coated with a film, and the surface is uneven because the code number is stamped on it.

For comparison, the same film tablet was placed in a coating pot or a glazing pot and rotated, while carnauba wax powder was poured into a roughly 15 mesh bag and sprinkled onto the film tablet to glaze it using the conventional glazing method. Processed.

The results of experiments using the polishing method of the present invention and the conventional polishing method described above are as shown in Table 2 below.

In the above experiment, carnauba wax was used at 800 da/kg of film tablet. As can be seen from Table 2 above, with the conventional polishing method, 0.05
However, according to the polishing method of the present invention, not a single defective tablet was found at the time of sorting, indicating that it is highly effective.

Example 2 The experimental method was the same as in Example 1. However, the film tablets used in this example were film-coated bare tablets with no code number stamped on them. The film tablet is 2201 ng/tablet. Further, carnauba wax was used at 500 square meters/1 kg of film tablets. The results obtained were as shown in Table 6 below.

Table 6 shows that the traditional polishing method resulted in 0.0% of defective tablets with a lot of carnauba wax adhering to the surface of the film tablet.
However, according to the polishing method of the present invention, such defective tablets were not found during sorting, and it was found that the effect was as great as in Example 1. did.

Example 6 The experimental method was the same as in Example 1. However, sugar-coated tablets were used in this example. Sugar-coated tablets are 310In9/tablet.

Carnauba wax used was 4001 nQ/1 sugar-coated tablet. The results obtained were as shown in Table 4 below.

As can be seen from Table 4, the conventional polishing method resulted in 0.01% of defective tablets with a large amount of carnauba wax adhering to the surface of sugar-coated tablets.
Although ~0.02% of defective tablets were found during sorting, according to the polishing method of the present invention, such defective tablets were not found during sorting, and it was recognized that the effect was excellent as in the above-mentioned example. It was done.

As is clear from the above, according to the present invention, a powder polishing agent is pressurized using a polishing agent dispersing device that has a constriction opening at the tip of a container and a filter with a relatively fine mesh in this constriction opening. The powdered polishing agent was sprayed onto the tablets by blowing air through the filter and from the aperture opening, thereby polishing the tablets. The polishing agent can be uniformly distributed over the tablets, thereby preventing the polishing agent from forming lumps on the tablets, and the polishing agent can be quickly distributed.

[Brief explanation of drawings]

FIG. 1 is a perspective view showing an embodiment of a polishing agent dispersing device used in the tablet polishing method of the present invention, and FIG. 6 shows a container of the dispersing device shown in FIG. 1 divided into two parts. FIG. 2 is a perspective view similar to FIG. 1 showing the constructed embodiment; Reference numeral 2 in the figure: Spraying device, 4: Cylindrical container, 6:
...Aperture opening, 8...Filter, 10...Piston device (pressure feeding device), 12.14...Screw, 16.18
...Half part of the container, 20...Rod. Agent Asamura Kōgai 4 name turtles

Claims (1)

[Claims] (11) The powder polishing agent is sprayed onto the tablets by spraying the powder polishing agent from the aperture opening through a filter with a relatively fine mesh using pressurized air, thereby polishing the tablets. (2) A container containing a powder polishing agent, a diaphragm opening provided at the tip of the container, and a relatively fine mesh provided in the diaphragm opening. A polishing agent dispersing device characterized in that the polishing agent dispersing device is characterized in that it has a filter, and a pressure feeding means for squirting the powder polishing agent in the container from the aperture opening through the filter using pressurized air. The polishing agent dispersing device according to claim 2, wherein the filter has a mesh of about 20 to 200 meshes. (4) The polishing agent dispersing device according to claim 2, A spraying device in which the area ratio of the aperture opening to the cross-sectional area of the container is approximately 1/10,000 to 1/2.7. , an area ratio of the aperture opening to the cross-sectional area of the container is about 1/204 to 1/69. (6) In the polishing agent spreading device according to claim 2, the container is The spraying device is a cylindrical container, and the pressure feeding means is a piston device that reciprocates within the cylindrical container. (7) In the polishing agent spraying device according to claim 5, the cylindrical The shaped container consists of two integral parts screwed into each other (spreading device).