JPS63246321A - Polishing of sugar-coated tablet - Google Patents
Polishing of sugar-coated tabletInfo
- Publication number
- JPS63246321A JPS63246321A JP8159487A JP8159487A JPS63246321A JP S63246321 A JPS63246321 A JP S63246321A JP 8159487 A JP8159487 A JP 8159487A JP 8159487 A JP8159487 A JP 8159487A JP S63246321 A JPS63246321 A JP S63246321A
- Authority
- JP
- Japan
- Prior art keywords
- sugar
- polishing
- lubricant
- coated tablets
- solid wax
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008298 dragée Substances 0.000 title claims abstract description 22
- 239000007940 sugar coated tablet Substances 0.000 title claims abstract description 21
- 238000005498 polishing Methods 0.000 title abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- 239000007787 solid Substances 0.000 claims abstract description 13
- 239000000314 lubricant Substances 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims description 11
- 239000001993 wax Substances 0.000 abstract description 12
- 239000003826 tablet Substances 0.000 abstract description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract description 6
- 235000013869 carnauba wax Nutrition 0.000 abstract description 4
- 239000004203 carnauba wax Substances 0.000 abstract description 4
- 239000002932 luster Substances 0.000 abstract description 4
- 235000019359 magnesium stearate Nutrition 0.000 abstract description 3
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 abstract description 2
- 235000013871 bee wax Nutrition 0.000 abstract description 2
- 239000012166 beeswax Substances 0.000 abstract description 2
- 239000000454 talc Substances 0.000 abstract description 2
- 229910052623 talc Inorganic materials 0.000 abstract description 2
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 239000012188 paraffin wax Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000009495 sugar coating Methods 0.000 description 2
- -1 IQ rough-in Substances 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005554 pickling Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は糖衣錠の艷出し方法、更に詳細には１錠剤の糖
衣表面を平滑にして美麗な艶を付与することのできる糖
衣錠の艷出し方法に関する。[Detailed Description of the Invention] [Field of Industrial Application] The present invention provides a method for unrolling sugar-coated tablets, and more specifically, a method for unrolling sugar-coated tablets that can smooth the sugar-coated surface of one tablet and impart a beautiful gloss. Regarding.
従来、糖衣錠の艷出し方法としては、錠剤と艷出し用固
形ワックスとを艷出し用ノｅノに入れ、回転させながら
これらを流動させる方法、あるいは上記ワックスを有機
溶媒に溶解乃至分散させて錠剤の流動表面に加える方法
が行われていた。Conventionally, methods for dispensing sugar-coated tablets include placing the tablet and a solid wax for dispensing in a dispensing nozzle and fluidizing them while rotating, or dissolving or dispersing the wax in an organic solvent to form tablets. A method of adding it to a flowing surface was used.
しかしながら、前者の方法は糖衣表面の平滑度が高くな
いと充分な艶が付与されないとか、固形ワックスが固り
になって艷出し効果が低下する等の欠点があり、また後
者の方法は有機溶媒が残留して人体に影響を及ぼす惧れ
がある等の欠点があり、何れの方法も満足し得るもので
はなかった。However, the former method has drawbacks such as insufficient gloss cannot be imparted unless the surface of the sugar coating is highly smooth, and the solid wax becomes hard, reducing the elutriation effect, while the latter method uses organic solvents. However, none of the methods were satisfactory because of the drawbacks such as the possibility that residual substances may affect the human body.
斯かる実情において、本発明者は上記欠点を克服せんと
鋭意研究を行った結果、従来の固形ワックスに滑沢剤を
加えた艷出し剤を使用すれば、糖衣錠に美麗な艶を付与
できることを見出し、本発明を完成した。Under these circumstances, the present inventor conducted intensive research to overcome the above-mentioned drawbacks, and as a result, discovered that it is possible to impart a beautiful luster to sugar-coated tablets by using a release agent made by adding a lubricant to a conventional solid wax. The present invention has been completed.
すなわち、本発明は、糖衣錠を艷出し用固形ワックス及
び滑沢剤よシなる艷出し剤と流動混合することを特徴と
する糖衣錠の艷出し方法を提供するものである。That is, the present invention provides a method for releasing sugar-coated tablets, which comprises fluidly mixing sugar-coated tablets with a releasing agent such as a solid wax and a lubricant.
本発明において、艷出し用固形ワックスとしては従来一
般に使用されているもの１例えばミツロウ、ＩＱラフイ
ン、カルナウバロウ等の１櫨又は２種以上の混合物が使
用される。In the present invention, as the solid wax for waxing, one or a mixture of two or more of conventionally used solid waxes such as beeswax, IQ rough-in, carnauba wax, etc. is used.
滑沢剤としてはメルク、ステアリン酸マグネシウム、合
成ケイ酸アルミニウム、メタケイ酸アルミン酸マグネシ
ウム等が挙げられ、これらは粒径５０μ以下のものが好
ましい。そして、この滑沢剤は、糖衣表面の凹凸を研磨
して平滑にすると共に、固形ワックスが凝集して固りと
なるのを防止する作用を奏する。Examples of the lubricant include Merck, magnesium stearate, synthetic aluminum silicate, magnesium aluminate metasilicate, etc., and these preferably have a particle size of 50 μm or less. This lubricant has the function of polishing and smoothing the irregularities on the surface of the sugar coating, and also of preventing the solid wax from agglomerating into a lump.
固形ワックスと滑沢剤の混合割合は９：１〜１：９（重
量）が好ましい。The mixing ratio of solid wax and lubricant is preferably 9:1 to 1:9 (by weight).
本発明方法を実施するには、例えば糖衣錠を艷出し用／
Ｑ７に入れ、これに上記艷出し剤を散布して流動混合す
る。艷出し剤の散布及び流動混合を何回か繰り返して行
うこともできる。散布する艷出し剤の量は、糖衣錠の大
きさによっても異なるが１例えば直径９ ｍｍの錠剤の
場合、１０００錠当り２００ｍｇが好ましい。糖衣錠と
艷出し剤の流動混合は約３０分間行えばよい。斯かる操
作の後残存する艷出し剤は分離除去する必要はなく、得
られた糖衣錠はそのまま使用に供される。To carry out the method of the present invention, for example, sugar-coated tablets may be
into Q7, sprinkle the above-mentioned release agent thereon, and fluidize the mixture. Spraying and fluid mixing of the release agent may be repeated several times. The amount of dispensing agent to be dispersed varies depending on the size of the sugar-coated tablet; for example, in the case of tablets with a diameter of 9 mm, it is preferably 200 mg per 1000 tablets. Fluid mixing of the dragee and the dispensing agent may be carried out for about 30 minutes. It is not necessary to separate and remove the pickling agent remaining after such an operation, and the resulting sugar-coated tablet can be used as is.
叙上の如く１本発明は、糖衣表面の平滑性に関係なく何
れの糖衣錠にも簡単な操作で美麗な艶を付与することが
できる。As described above, the present invention can impart a beautiful gloss to any sugar-coated tablet with a simple operation, regardless of the smoothness of the sugar-coated surface.
実施例１ カルナウバロウ１ｏｏｏ＃及びタルク １０００ηを均一に混合して艷出し剤とした。 Example 1 Carnauba wax 1ooo# and talc 1000η was mixed uniformly to prepare a release agent.
糖衣錠（直径９ｍｍ）ＩＱＯＯＯ錠を艷出し用ノーンに
入れ、艷出し剤１ｏｏｏｍｇ２散布して１５分間流動混
合した後、更に艷出し剤１０００ηを散布して１５分間
流動混合して、１錠当りＱ：２ＲＩＩの艷出し剤を含有
する美麗な艶を有する糖衣錠を得た。Sugar-coated tablets (diameter 9 mm) IQOOO tablets were placed in a noon for release, sprinkled with 100mg2 of release agent and mixed for 15 minutes, then further sprinkled with 1000η of release agent and mixed for 15 minutes.Q per tablet: Sugar-coated tablets containing a 2RII release agent and having a beautiful luster were obtained.
実施例２
カルナウバロウ１４００■及びステアリン酸マグネシウ
ムｅｏｏｑ２均一に混合して艷出し剤とした。この艷出
し剤を用いて実施例１と同様に操作し、１前当シα２１
１Ｉｇの艷出し剤を含有する美麗な艶を有する糖衣錠を
得た。Example 2 Carnauba wax 1400■ and magnesium stearate eooq2 were uniformly mixed to prepare a release agent. Using this elutriation agent, operate in the same manner as in Example 1.
Sugar-coated tablets containing 1 Ig of a dissolving agent and having a beautiful luster were obtained.
以上that's all
Claims (1)
艷出し剤と流動混合することを特徴とする糖衣錠の艷出
し方法。 ２、艷出し用固形ワックスと滑沢剤の混合割合が１：９
〜９：１（重量）である特許請求の範囲第１項記載の糖
衣錠の艷出し方法。[Scope of Claims] 1. A method for releasing sugar-coated tablets, which comprises fluidly mixing sugar-coated tablets with a releasing agent consisting of a solid wax for releasing and a lubricant. 2. The mixing ratio of solid wax for ejection and lubricant is 1:9.
9:1 (by weight), the method for extracting sugar-coated tablets according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62081594A JPH0753664B2 (en) | 1987-04-02 | 1987-04-02 | How to polish sugar-coated tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62081594A JPH0753664B2 (en) | 1987-04-02 | 1987-04-02 | How to polish sugar-coated tablets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63246321A true JPS63246321A (en) | 1988-10-13 |
| JPH0753664B2 JPH0753664B2 (en) | 1995-06-07 |
Family
ID=13750641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62081594A Expired - Lifetime JPH0753664B2 (en) | 1987-04-02 | 1987-04-02 | How to polish sugar-coated tablets |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0753664B2 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58159749A (en) * | 1982-03-17 | 1983-09-22 | 帝国臓器製薬株式会社 | Polishing of tablet and polishing agent scattering apparatus |
-
1987
- 1987-04-02 JP JP62081594A patent/JPH0753664B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58159749A (en) * | 1982-03-17 | 1983-09-22 | 帝国臓器製薬株式会社 | Polishing of tablet and polishing agent scattering apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0753664B2 (en) | 1995-06-07 |
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