JPS58152492A - ２−ケト−ｌ−グロン酸の製造方法 - Google Patents
２−ケト−ｌ−グロン酸の製造方法Info
- Publication number
- JPS58152492A JPS58152492A JP3545482A JP3545482A JPS58152492A JP S58152492 A JPS58152492 A JP S58152492A JP 3545482 A JP3545482 A JP 3545482A JP 3545482 A JP3545482 A JP 3545482A JP S58152492 A JPS58152492 A JP S58152492A
- Authority
- JP
- Japan
- Prior art keywords
- gluconic acid
- diketo
- keto
- acid
- strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VBUYCZFBVCCYFD-NUNKFHFFSA-N 2-dehydro-L-idonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-NUNKFHFFSA-N 0.000 title claims abstract description 17
- VBUYCZFBVCCYFD-UHFFFAOYSA-N D-arabino-2-Hexulosonic acid Natural products OCC(O)C(O)C(O)C(=O)C(O)=O VBUYCZFBVCCYFD-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 238000000034 method Methods 0.000 claims abstract description 20
- 239000004094 surface-active agent Substances 0.000 claims abstract description 20
- 230000004060 metabolic process Effects 0.000 claims abstract description 9
- 241000589236 Gluconobacter Species 0.000 claims abstract description 7
- 241000588698 Erwinia Species 0.000 claims abstract description 5
- 229950006191 gluconic acid Drugs 0.000 claims description 43
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 24
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 20
- 235000012208 gluconic acid Nutrition 0.000 claims description 20
- 230000001954 sterilising effect Effects 0.000 claims description 11
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
- RGHNJXZEOKUKBD-QTBDOELSSA-N L-gulonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O RGHNJXZEOKUKBD-QTBDOELSSA-N 0.000 claims description 8
- 230000002950 deficient Effects 0.000 claims description 8
- 239000000174 gluconic acid Substances 0.000 claims description 5
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 241000186216 Corynebacterium Species 0.000 claims 1
- 239000000758 substrate Substances 0.000 abstract description 13
- VBUYCZFBVCCYFD-YVZJFKFKSA-N 2-dehydro-L-gluconic acid Chemical compound OC[C@H](O)[C@H](O)[C@@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-YVZJFKFKSA-N 0.000 abstract description 4
- 244000005700 microbiome Species 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 3
- 238000000354 decomposition reaction Methods 0.000 abstract description 2
- RXMWXENJQAINCC-DMTCNVIQSA-N 2,5-didehydro-D-gluconic acid Chemical compound OCC(=O)[C@@H](O)[C@H](O)C(=O)C(O)=O RXMWXENJQAINCC-DMTCNVIQSA-N 0.000 abstract 5
- RXMWXENJQAINCC-UHFFFAOYSA-N 2,5-diketo-D-gluconic acid Natural products OCC(=O)C(O)C(O)C(=O)C(O)=O RXMWXENJQAINCC-UHFFFAOYSA-N 0.000 abstract 5
- 239000001963 growth medium Substances 0.000 abstract 5
- 239000002609 medium Substances 0.000 abstract 2
- IZSRJDGCGRAUAR-MROZADKFSA-N 5-dehydro-D-gluconic acid Chemical compound OCC(=O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O IZSRJDGCGRAUAR-MROZADKFSA-N 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 description 26
- 230000004151 fermentation Effects 0.000 description 26
- 239000000243 solution Substances 0.000 description 26
- 239000007788 liquid Substances 0.000 description 18
- 241000894006 Bacteria Species 0.000 description 9
- 238000004659 sterilization and disinfection Methods 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 238000011218 seed culture Methods 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 241000186249 Corynebacterium sp. Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- WTAHRPBPWHCMHW-PAKKCRSFSA-N 3-dehydro-D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)C(=O)[C@@H](O)C(O)=O WTAHRPBPWHCMHW-PAKKCRSFSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 241000589220 Acetobacter Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 101100136092 Drosophila melanogaster peng gene Proteins 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000004816 paper chromatography Methods 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000006227 trimethylsilylation reaction Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3545482A JPS58152492A (ja) | 1982-03-05 | 1982-03-05 | ２−ケト−ｌ−グロン酸の製造方法 |
| US06/469,780 US4543331A (en) | 1982-03-05 | 1983-02-25 | Fermentative or enzymatic production of 2-keto-L-gulonic acid |
| DK103583A DK161106C (da) | 1982-03-05 | 1983-02-28 | Fremgangsmaade til fremstilling af 2-keto-l-gulonsyre |
| ES520323A ES8404411A1 (es) | 1982-03-05 | 1983-03-04 | Un procedimiento mejorado para preparar acido 2-ceto-l-gulonico. |
| AU12050/83A AU562910B2 (en) | 1982-03-05 | 1983-03-04 | Process for preparing 2-keto-l-gulonic acid |
| DE8383102164T DE3364468D1 (en) | 1982-03-05 | 1983-03-04 | Process for preparing 2-keto-l-gulonic acid and mutants therefor |
| KR1019830000883A KR900009051B1 (ko) | 1982-03-05 | 1983-03-04 | 2-케토-l-굴론산의 제조방법 |
| EP83102164A EP0088408B1 (en) | 1982-03-05 | 1983-03-04 | Process for preparing 2-keto-l-gulonic acid and mutants therefor |
| HU83755A HU195536B (en) | 1982-03-05 | 1983-03-04 | Process for producing 2-keto-l-gulonic acid |
| GB08306232A GB2116549B (en) | 1982-03-05 | 1983-03-07 | Process for preparing 2-keto-l-gulonic acid |
| IE487/83A IE54704B1 (en) | 1982-03-05 | 1983-03-07 | Process for preparing 2-keto-l-gulonic acid |
| CA000422970A CA1200220A (en) | 1982-03-05 | 1983-03-07 | Process for preparing 2-keto-l-gulonic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3545482A JPS58152492A (ja) | 1982-03-05 | 1982-03-05 | ２−ケト−ｌ−グロン酸の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58152492A true JPS58152492A (ja) | 1983-09-10 |
| JPH0369515B2 JPH0369515B2 (enrdf_load_stackoverflow) | 1991-11-01 |
Family
ID=12442245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3545482A Granted JPS58152492A (ja) | 1982-03-05 | 1982-03-05 | ２−ケト−ｌ−グロン酸の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58152492A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971679A (zh) * | 2015-06-26 | 2015-10-14 | 开平市开物化工建材有限公司 | 智能聚合硫酸铝铁制备及固化装置 |
-
1982
- 1982-03-05 JP JP3545482A patent/JPS58152492A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0369515B2 (enrdf_load_stackoverflow) | 1991-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3192487B2 (ja) | 発酵方法 | |
| DE2530861C3 (de) | Verfahren zur Herstellung von 2-Keto-L-gulonsäure und deren Salzen | |
| DE2413963A1 (de) | Verfahren zur herstellung von 2-ketol-gulonsaeure und deren salzen auf mikrobiologischem wege | |
| DD221905A1 (de) | Verfahren zur herstellung von l(-)-carnitin und seinen derivaten | |
| JPH0357756B2 (enrdf_load_stackoverflow) | ||
| EP0088408B1 (en) | Process for preparing 2-keto-l-gulonic acid and mutants therefor | |
| US4696897A (en) | Process for preparing 2-keto-L-gulonic acid | |
| US3790444A (en) | Process for preparing diketogluconic acid | |
| CH658867A5 (de) | Verfahren zur herstellung von 6-hydroxynikotinsaeure. | |
| KR100233330B1 (ko) | 6-히드록시피콜린산을 제조하기 위한 미생물학적 방법 | |
| JPS58152492A (ja) | ２−ケト−ｌ−グロン酸の製造方法 | |
| TW515844B (en) | A fermentation method for producing 2-keto-L-gulonic acid | |
| US1913346A (en) | Production of aliphatic acids | |
| US4210720A (en) | Process for fermentatively producing vitamin B12 | |
| EP0717111B1 (de) | Mikrobilles Verfahren zur Herstellung von Dihydroxyaceton unter Rückführung von Biomasse | |
| JPS58201985A (ja) | グルコ−ス脱水素酵素の生産方法 | |
| CA1119981A (en) | Process for preparing 2,5-diketogluconic acid | |
| JP2003088392A (ja) | Ｄ−乳酸の製造方法 | |
| CN108315364A (zh) | 生物转化制备α-酮戊二酸的分离纯化工艺 | |
| JPH0337918B2 (enrdf_load_stackoverflow) | ||
| JPH03164166A (ja) | ５―ケト―ｄ―グルコン酸代謝欠損変異株 | |
| CN116590212A (zh) | 一种提高丁酸梭菌芽孢转化率的方法 | |
| JPS6225357B2 (enrdf_load_stackoverflow) | ||
| JPS58162296A (ja) | ２−ケト−ｌ−グロン酸の製造方法 | |
| DD278362A1 (de) | Verfahren zur gewinnung von 2-oxogluconsaeure mittels bakterien |