JPS58109411A - ニフエジピン固型製剤組成物 - Google Patents
ニフエジピン固型製剤組成物Info
- Publication number
- JPS58109411A JPS58109411A JP21183381A JP21183381A JPS58109411A JP S58109411 A JPS58109411 A JP S58109411A JP 21183381 A JP21183381 A JP 21183381A JP 21183381 A JP21183381 A JP 21183381A JP S58109411 A JPS58109411 A JP S58109411A
- Authority
- JP
- Japan
- Prior art keywords
- nifedipine
- binder
- organic solvent
- plasticizer
- elution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title claims abstract description 36
- 229960001597 nifedipine Drugs 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims description 18
- 239000007787 solid Substances 0.000 title claims description 12
- 239000011230 binding agent Substances 0.000 claims abstract description 24
- 239000003960 organic solvent Substances 0.000 claims abstract description 10
- 239000004014 plasticizer Substances 0.000 claims abstract description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- -1 glycerol ester Chemical class 0.000 claims abstract description 5
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims abstract description 4
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims abstract description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims abstract description 3
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims abstract description 3
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims abstract description 3
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 3
- 239000011148 porous material Substances 0.000 claims description 8
- 230000001419 dependent effect Effects 0.000 claims description 5
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 239000013022 formulation composition Substances 0.000 claims 1
- 238000010828 elution Methods 0.000 abstract description 15
- 239000002904 solvent Substances 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 4
- 235000011187 glycerol Nutrition 0.000 abstract description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 description 20
- 238000004090 dissolution Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000007922 dissolution test Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000007962 solid dispersion Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 239000006104 solid solution Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920003136 Eudragit® L polymer Polymers 0.000 description 1
- 229920003137 Eudragit® S polymer Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011268 mixed slurry Substances 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21183381A JPS58109411A (ja) | 1981-12-23 | 1981-12-23 | ニフエジピン固型製剤組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21183381A JPS58109411A (ja) | 1981-12-23 | 1981-12-23 | ニフエジピン固型製剤組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58109411A true JPS58109411A (ja) | 1983-06-29 |
| JPH0220610B2 JPH0220610B2 (enrdf_load_stackoverflow) | 1990-05-10 |
Family
ID=16612342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21183381A Granted JPS58109411A (ja) | 1981-12-23 | 1981-12-23 | ニフエジピン固型製剤組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58109411A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4940556A (en) * | 1986-01-30 | 1990-07-10 | Syntex (U.S.A.) Inc. | Method of preparing long acting formulation |
| JPH02223522A (ja) * | 1988-11-30 | 1990-09-05 | Banyu Pharmaceut Co Ltd | Ｎｂ―８１８の易吸収性製剤 |
| WO1992001453A1 (en) * | 1990-07-19 | 1992-02-06 | Otsuka Pharmaceutical Co., Ltd. | Solid preparation |
| US5198226A (en) * | 1986-01-30 | 1993-03-30 | Syntex (U.S.A.) Inc. | Long acting nicardipine hydrochloride formulation |
| EP0580860A4 (en) * | 1991-04-16 | 1994-06-15 | Nippon Shinyaku Co Ltd | Method of manufacturing solid dispersion |
| EP0521310A3 (en) * | 1991-06-05 | 1994-10-05 | Fujirebio Kk | Solid dispersion tablets containing 1,4-dihydropyridine derivatives and process for the preparation thereof |
| JP2010527347A (ja) * | 2007-05-17 | 2010-08-12 | ヤゴテック アーゲー | メタケイ酸アルミン酸マグネシウム含有放出制御錠剤 |
-
1981
- 1981-12-23 JP JP21183381A patent/JPS58109411A/ja active Granted
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4940556A (en) * | 1986-01-30 | 1990-07-10 | Syntex (U.S.A.) Inc. | Method of preparing long acting formulation |
| US5198226A (en) * | 1986-01-30 | 1993-03-30 | Syntex (U.S.A.) Inc. | Long acting nicardipine hydrochloride formulation |
| JPH02223522A (ja) * | 1988-11-30 | 1990-09-05 | Banyu Pharmaceut Co Ltd | Ｎｂ―８１８の易吸収性製剤 |
| WO1992001453A1 (en) * | 1990-07-19 | 1992-02-06 | Otsuka Pharmaceutical Co., Ltd. | Solid preparation |
| US5316773A (en) * | 1990-07-19 | 1994-05-31 | Otsuka Pharmaceutical Co., Ltd. | Particulate preparation containing a flourracil derivative and hydroxypropylmethyl-cellulose |
| EP0580860A4 (en) * | 1991-04-16 | 1994-06-15 | Nippon Shinyaku Co Ltd | Method of manufacturing solid dispersion |
| EP0521310A3 (en) * | 1991-06-05 | 1994-10-05 | Fujirebio Kk | Solid dispersion tablets containing 1,4-dihydropyridine derivatives and process for the preparation thereof |
| JP2010527347A (ja) * | 2007-05-17 | 2010-08-12 | ヤゴテック アーゲー | メタケイ酸アルミン酸マグネシウム含有放出制御錠剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0220610B2 (enrdf_load_stackoverflow) | 1990-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5149542A (en) | Coating membrane and compositions prepared therefrom | |
| CA1218305A (en) | Combination formulation | |
| AU596804B2 (en) | A granular delayed-release form of pharmaceutically active substances | |
| US5576022A (en) | Controlled release tacrine drug delivery systems and methods for preparing same | |
| CN103347503B (zh) | 泡腾γ-羟基丁酸颗粒剂 | |
| US3344029A (en) | Sustained release composition | |
| EP0142561B1 (en) | Long-acting nifedipine preparation | |
| EP0431877B1 (en) | Cimetidine pharmaceutical compositions | |
| EP0533297B1 (en) | Controlled-release pharmaceutical formulations | |
| ES2298551T3 (es) | Formulacion farmaceutica oral en forma de una pluralidad de microcapsulas que permiten la liberacion prolongada de principio(s) activo(s) poco soluble(s). | |
| JP2012508784A (ja) | γ−ヒドロキシ酪酸に基づく新規の組成物 | |
| US3939259A (en) | Coating composition and therapeutic preparation incorporating same | |
| JPH04224517A (ja) | 標的制御釈放薬剤 | |
| HRP20020119A2 (en) | Taste masked pharmaceutical liquid formulations | |
| PT1492511E (pt) | Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s) | |
| JP3804029B2 (ja) | ジルチアゼム処方剤 | |
| AU2009247921B2 (en) | Solid oral form with dual release profile, containing multiparticulates | |
| JPS6327439A (ja) | 持続性薬効製剤 | |
| JPH0259515A (ja) | 鎮痛活性及び抗炎症活性を有し、優れた嗜好性をもち、且つ粘膜に刺激作用のない経口投与用製薬組成物 | |
| JP2004507487A (ja) | 腸疾患治療薬 | |
| CS396391A3 (en) | Theophyline-containing retarded preparation | |
| JPS59139317A (ja) | 持続性のニフエジピン製剤 | |
| ES2584403T3 (es) | Procedimiento de elaboración de microcápsulas entéricas de alginato por gelación iónica que contienen diclofenac o una de sus sales y composición farmacéutica multiparticulada que las contiene | |
| JPS58109411A (ja) | ニフエジピン固型製剤組成物 | |
| JPH0157090B2 (enrdf_load_stackoverflow) |