JPS5799539A - Preparation of alpha-(p-butylphenyl)-ethyl halide - Google Patents
Preparation of alpha-(p-butylphenyl)-ethyl halideInfo
- Publication number
- JPS5799539A JPS5799539A JP17630480A JP17630480A JPS5799539A JP S5799539 A JPS5799539 A JP S5799539A JP 17630480 A JP17630480 A JP 17630480A JP 17630480 A JP17630480 A JP 17630480A JP S5799539 A JPS5799539 A JP S5799539A
- Authority
- JP
- Japan
- Prior art keywords
- butylphenyl
- acid
- raw material
- ethyl alcohol
- butyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a raw material for preparing medicines in high purity and yield by an easy operation, by reacting an inexpensive and industrially easily handleable hydrohalogenic acid with an α-(p- butylphenyl)-ethyl alcohol.
CONSTITUTION: An α-(p-butylphenyl)-ethyl alcohol is dissolved in a waterinsoluble solvent, e.g. toluene, diethyl ether or n-hexane, and an excess of hydrohalogenic acid, e.g. 35% hydrochloric acid or hydrobromic acid, is added to the solution and stirred to carry out the halogenation reaction at ordinary temperature or near the ordinary temperature for several hours. Thus, an oily α-(p-butylphenyl)- ethyl halide is obtained quantitatively. The butyl group is n-butyl, isobutyl, secondary or tertiary butyl group.
USE: A raw material for preparing α-(p-isobutylphenyl)-propionic acid which is an anti-inflammatory agent, etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17630480A JPS5799539A (en) | 1980-12-13 | 1980-12-13 | Preparation of alpha-(p-butylphenyl)-ethyl halide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17630480A JPS5799539A (en) | 1980-12-13 | 1980-12-13 | Preparation of alpha-(p-butylphenyl)-ethyl halide |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5799539A true JPS5799539A (en) | 1982-06-21 |
Family
ID=16011240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17630480A Pending JPS5799539A (en) | 1980-12-13 | 1980-12-13 | Preparation of alpha-(p-butylphenyl)-ethyl halide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5799539A (en) |
-
1980
- 1980-12-13 JP JP17630480A patent/JPS5799539A/en active Pending
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