JPS5795917A - Preparation of inactivated sendai virus vaccine - Google Patents
Preparation of inactivated sendai virus vaccineInfo
- Publication number
- JPS5795917A JPS5795917A JP17179580A JP17179580A JPS5795917A JP S5795917 A JPS5795917 A JP S5795917A JP 17179580 A JP17179580 A JP 17179580A JP 17179580 A JP17179580 A JP 17179580A JP S5795917 A JPS5795917 A JP S5795917A
- Authority
- JP
- Japan
- Prior art keywords
- sendai virus
- hvj
- water
- pellet
- mole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare titled safe and effective vaccine useful for preventing the infection with Sendai virus, by treating the pellet of Sendai virus with a nonionic surface-active agent and an organic solvent which is not completely miscible with water, in the absence of salts.
CONSTITUTION: The pellet of Sendai virus (another name: Hemagglutionating Virus of Japan; abbr. HVJ) is treated with a nonionic surface-active agent (e.g. polyoxyethylene sorbitan monolaurate) and an organic solvent (e.g. ethyl ether) which is not completely miscible with water, essentially in the absence of salts (e.g. physiological sline water, buffer solutions, etc; the concentration of salt is <1m-mole, pref.<0.5m-mole) to obtain the objective inactivated HVJ vaccine. In has high immunity titer and low toxicity, and can be inoculated safely to mammalians (e.g. rodents such as mouse) having sensitivity to HVJ.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17179580A JPS5795917A (en) | 1980-12-04 | 1980-12-04 | Preparation of inactivated sendai virus vaccine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17179580A JPS5795917A (en) | 1980-12-04 | 1980-12-04 | Preparation of inactivated sendai virus vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5795917A true JPS5795917A (en) | 1982-06-15 |
Family
ID=15929832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17179580A Pending JPS5795917A (en) | 1980-12-04 | 1980-12-04 | Preparation of inactivated sendai virus vaccine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5795917A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554158A (en) * | 1983-04-07 | 1985-11-19 | Simonsen Laboratories, Inc. | Modified live sendai virus vaccine for administering through an aerosol and method of producing the same |
WO2005120579A1 (en) * | 2004-06-14 | 2005-12-22 | Ishihara Sangyo Kaisha, Ltd. | Freeze-dried composition of inactivated virus envelope with membrane fusion activity |
-
1980
- 1980-12-04 JP JP17179580A patent/JPS5795917A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554158A (en) * | 1983-04-07 | 1985-11-19 | Simonsen Laboratories, Inc. | Modified live sendai virus vaccine for administering through an aerosol and method of producing the same |
WO2005120579A1 (en) * | 2004-06-14 | 2005-12-22 | Ishihara Sangyo Kaisha, Ltd. | Freeze-dried composition of inactivated virus envelope with membrane fusion activity |
US20080102524A1 (en) * | 2004-06-14 | 2008-05-01 | Ishihara Sangyo Kaisha, Ltd. | Freeze-Dried Composition of Inactivated Virus Envelope with Membrane Fusion Activity |
US8043610B2 (en) | 2004-06-14 | 2011-10-25 | Ishihara Sangyo Kaisha, Ltd. | Freeze-dried composition of inactivated virus envelope with membrane fusion activity |
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