JPS54125671A - Lonomycin compound - Google Patents
Lonomycin compoundInfo
- Publication number
- JPS54125671A JPS54125671A JP3018878A JP3018878A JPS54125671A JP S54125671 A JPS54125671 A JP S54125671A JP 3018878 A JP3018878 A JP 3018878A JP 3018878 A JP3018878 A JP 3018878A JP S54125671 A JPS54125671 A JP S54125671A
- Authority
- JP
- Japan
- Prior art keywords
- lonomycin
- compound
- salt
- formula
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BKZOUCVNTCLNFF-UHFFFAOYSA-N Lonomycin Natural products COC1C(C)C(C2(C)OC(CC2)C2(C)OC3(OC(C(C)C(OC)C3)C(C)C3C(C(OC)C(C)C(O)(C(C)C(O)=O)O3)C)CC2)OC1C1OC(C)(O)C(C)C(OC)C1C BKZOUCVNTCLNFF-UHFFFAOYSA-N 0.000 title abstract 4
- -1 Lonomycin compound Chemical class 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- BKZOUCVNTCLNFF-IGXZVFLKSA-N (2s)-2-[(2r,3r,4s,5r,6s)-2-hydroxy-6-[(1s)-1-[(2s,5r,7s,8r,9s)-2-[(2r,5s)-5-[(2r,3s,4r,5r)-5-[(2s,3s,4s,5r,6s)-6-hydroxy-4-methoxy-3,5,6-trimethyloxan-2-yl]-4-methoxy-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,8-dimethyl-1,10-dioxaspiro[4.5]dec Chemical compound O([C@@H]1[C@@H]2O[C@H]([C@@H](C)[C@H]2OC)[C@@]2(C)O[C@H](CC2)[C@@]2(C)O[C@]3(O[C@@H]([C@H](C)[C@@H](OC)C3)[C@@H](C)[C@@H]3[C@@H]([C@H](OC)[C@@H](C)[C@](O)([C@H](C)C(O)=O)O3)C)CC2)[C@](C)(O)[C@H](C)[C@@H](OC)[C@@H]1C BKZOUCVNTCLNFF-IGXZVFLKSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A lonomycin compound of formula or its salt.
USE: Low toxic medicine effective to protozoa such as coccidium, bacteria, virus, etc.
PROCESS: The compound of the formula is prepared by dissolving lonomycin or its salt in an inert organic solvent which is miscible with water, and reducing with sodium borohydride at room temperature. The lonomycin compound can be converted to various salt by conventional processes. Sodium salt or potassium salt is preferable in view of the handleability.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3018878A JPS54125671A (en) | 1978-03-16 | 1978-03-16 | Lonomycin compound |
GB7905483A GB2024806B (en) | 1978-03-16 | 1979-02-16 | Onomycin derivatives |
DE19792907976 DE2907976A1 (en) | 1978-03-16 | 1979-03-01 | NEW LONOMYCIN DERIVATIVES |
CH219679A CH637963A5 (en) | 1978-03-16 | 1979-03-07 | LONOMYCIN DERIVATIVES WITH ANTI-BACTERIAL, ANTI-VIRAL AND ANTI-PROTOZOA ACTIVITIES. |
FR7906172A FR2419945A1 (en) | 1978-03-16 | 1979-03-09 | LONOMYCIN DERIVATIVES WITH ANTI-BACTERIAL, ANTI-VIRAL AND ANTI-PROTOZOA ACTIVITIES |
US06/018,935 US4199515A (en) | 1978-03-16 | 1979-03-09 | Novel lonomycin derivatives |
IT48363/79A IT1114711B (en) | 1978-03-16 | 1979-03-15 | LONOMYCIN DERIVATIVES WITH ANTIVIRAL AND ANTIPROTOZOIC ANTIBACTERIAL ACTIVITY |
CA323,617A CA1111419A (en) | 1978-03-16 | 1979-03-15 | Lonomycin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3018878A JPS54125671A (en) | 1978-03-16 | 1978-03-16 | Lonomycin compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54125671A true JPS54125671A (en) | 1979-09-29 |
Family
ID=12296771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3018878A Pending JPS54125671A (en) | 1978-03-16 | 1978-03-16 | Lonomycin compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54125671A (en) |
-
1978
- 1978-03-16 JP JP3018878A patent/JPS54125671A/en active Pending
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