JPS5794660A - Measurement of inhibitor-enzyme compound - Google Patents
Measurement of inhibitor-enzyme compoundInfo
- Publication number
- JPS5794660A JPS5794660A JP56154047A JP15404781A JPS5794660A JP S5794660 A JPS5794660 A JP S5794660A JP 56154047 A JP56154047 A JP 56154047A JP 15404781 A JP15404781 A JP 15404781A JP S5794660 A JPS5794660 A JP S5794660A
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- inhibitor
- enzyme inhibitor
- antibody
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19216680A | 1980-09-30 | 1980-09-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5794660A true JPS5794660A (en) | 1982-06-12 |
JPH041304B2 JPH041304B2 (ja) | 1992-01-10 |
Family
ID=22708529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56154047A Granted JPS5794660A (en) | 1980-09-30 | 1981-09-30 | Measurement of inhibitor-enzyme compound |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0048989B1 (ja) |
JP (1) | JPS5794660A (ja) |
AT (1) | ATE15387T1 (ja) |
CA (1) | CA1176560A (ja) |
DE (1) | DE3172143D1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6134465A (ja) * | 1984-07-26 | 1986-02-18 | Teijin Ltd | ヒトα↓2−プラスミンインヒビタ−に対するモノクロ−ナル抗体を用いた免疫学的測定試薬及びキツト |
JPS6488368A (en) * | 1987-09-30 | 1989-04-03 | Shigeru Hayashi | Method for measuring complex of urokinase and urokinase inhibitor |
JP2016511394A (ja) * | 2013-01-20 | 2016-04-14 | ダイアックス コーポレーション | pKal関連疾病の評価、アッセイおよび治療 |
US11754570B2 (en) | 2019-04-16 | 2023-09-12 | Takeda Pharmaceutical Company Limited | Methods for quantitation of functional C1 esterase inhibitor (FC1-INH) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0080279B1 (en) * | 1981-11-02 | 1986-02-05 | James Walter Ryan | Method for assaying proteases with tagged proteinaceous inhibitors |
US4499186A (en) * | 1982-12-30 | 1985-02-12 | University Of Illinois, Board Of Trustees | Diagnosing autoimmune rheumatoid arthritis by measuring proteolytic activity of α2 -macroglobulin |
DE3531778A1 (de) * | 1985-09-06 | 1987-03-12 | Behringwerke Ag | Verfahren zur bestimmung von proteaseinhibitoren |
GB9119102D0 (en) * | 1991-09-07 | 1991-10-23 | Biosyn Ltd | Bioimmunassay |
GB9312638D0 (en) * | 1993-06-18 | 1993-08-04 | Hafslund Nycomed As | Assay |
NL9301134A (nl) * | 1993-06-29 | 1995-01-16 | Inst Voor Agrotech Onderzoek | Werkwijze voor het detekteren en eventueel kwantificeren van aktiviteit van ten minste één protease-inhibitor in een te analyseren mengsel, alsmede toepassing van de werkwijze voor het bepalen van de (rest)aktiviteit van één (of meer) afzonderlijke (iso)type(s) protease-inhibitor(en) en toepassing van de werkwijze voor het bepalen van de totale (rest)aktiviteit van een mengsel eventueel na een verwerkingsproces zoals een proces ter verwijdering of inaktivatie van protease-inhibitor(en). |
FI100557B (fi) * | 1994-08-26 | 1997-12-31 | Ulf-Haakan Stenman | Vapaan trypsinogeeni-2:n määritys |
EP0759556A3 (de) * | 1995-07-24 | 1998-05-20 | BEHRINGWERKE Aktiengesellschaft | Verfahren zur Quantifizierung aktivierter Faktoren |
WO2005017138A2 (en) * | 2003-08-19 | 2005-02-24 | Novozymes A/S | Active-site titration of glycosyl hydrolases |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5530692A (en) * | 1978-08-17 | 1980-03-04 | Behringwerke Ag | Method of immunological measuring |
JPS5646465A (en) * | 1979-09-25 | 1981-04-27 | Seikagaku Kogyo Co Ltd | Measuring method for man pancreas secretory inhibiter in humor |
JPS56118671A (en) * | 1980-02-22 | 1981-09-17 | Amano Pharmaceut Co Ltd | Measuring method of specific enzyme immunity of hybrid type protein |
JPS57551A (en) * | 1980-04-30 | 1982-01-05 | Merck Patent Gmbh | Immunologic measuring method and means of enzyme |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7602422A (nl) * | 1976-03-08 | 1977-09-12 | Leuven Res & Dev Vzw | Trombosetest. |
-
1981
- 1981-09-29 DE DE8181107730T patent/DE3172143D1/de not_active Expired
- 1981-09-29 AT AT81107730T patent/ATE15387T1/de not_active IP Right Cessation
- 1981-09-29 CA CA000386866A patent/CA1176560A/en not_active Expired
- 1981-09-29 EP EP81107730A patent/EP0048989B1/en not_active Expired
- 1981-09-30 JP JP56154047A patent/JPS5794660A/ja active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5530692A (en) * | 1978-08-17 | 1980-03-04 | Behringwerke Ag | Method of immunological measuring |
JPS5646465A (en) * | 1979-09-25 | 1981-04-27 | Seikagaku Kogyo Co Ltd | Measuring method for man pancreas secretory inhibiter in humor |
JPS56118671A (en) * | 1980-02-22 | 1981-09-17 | Amano Pharmaceut Co Ltd | Measuring method of specific enzyme immunity of hybrid type protein |
JPS57551A (en) * | 1980-04-30 | 1982-01-05 | Merck Patent Gmbh | Immunologic measuring method and means of enzyme |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6134465A (ja) * | 1984-07-26 | 1986-02-18 | Teijin Ltd | ヒトα↓2−プラスミンインヒビタ−に対するモノクロ−ナル抗体を用いた免疫学的測定試薬及びキツト |
JPH0441783B2 (ja) * | 1984-07-26 | 1992-07-09 | Teijin Ltd | |
JPS6488368A (en) * | 1987-09-30 | 1989-04-03 | Shigeru Hayashi | Method for measuring complex of urokinase and urokinase inhibitor |
JP2016511394A (ja) * | 2013-01-20 | 2016-04-14 | ダイアックス コーポレーション | pKal関連疾病の評価、アッセイおよび治療 |
US10690670B2 (en) | 2013-01-20 | 2020-06-23 | Dyax Corp. | Assays for determining levels of plasma protease C1 inhibitor |
US11892450B2 (en) | 2013-01-20 | 2024-02-06 | Takeda Pharmaceutical Company Limited | Evaluation, assays and treatment of pKal-mediated disorders |
US11754570B2 (en) | 2019-04-16 | 2023-09-12 | Takeda Pharmaceutical Company Limited | Methods for quantitation of functional C1 esterase inhibitor (FC1-INH) |
Also Published As
Publication number | Publication date |
---|---|
JPH041304B2 (ja) | 1992-01-10 |
ATE15387T1 (de) | 1985-09-15 |
EP0048989A2 (en) | 1982-04-07 |
DE3172143D1 (en) | 1985-10-10 |
EP0048989B1 (en) | 1985-09-04 |
CA1176560A (en) | 1984-10-23 |
EP0048989A3 (en) | 1982-05-12 |
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