JPS5791964A - Manufacture of reactive bondable derivatives of thyroid hormone 3,3',5-triiodothyronine (t3) and 3,3',5,5'-tetraiodothyronine (t4) - Google Patents

Manufacture of reactive bondable derivatives of thyroid hormone 3,3',5-triiodothyronine (t3) and 3,3',5,5'-tetraiodothyronine (t4)

Info

Publication number
JPS5791964A
JPS5791964A JP56158879A JP15887981A JPS5791964A JP S5791964 A JPS5791964 A JP S5791964A JP 56158879 A JP56158879 A JP 56158879A JP 15887981 A JP15887981 A JP 15887981A JP S5791964 A JPS5791964 A JP S5791964A
Authority
JP
Japan
Prior art keywords
reactive
derivatives
thyroid hormone
tetraiodothyronine
triiodothyronine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56158879A
Other languages
English (en)
Inventor
Batsutsu Hansuugeoruku
Aruberuto Buinfuriito
Rentsu Herumuuto
Rinke Hansuurarufu
Shiyuteeraa Furitsutsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPS5791964A publication Critical patent/JPS5791964A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
JP56158879A 1980-10-07 1981-10-07 Manufacture of reactive bondable derivatives of thyroid hormone 3,3',5-triiodothyronine (t3) and 3,3',5,5'-tetraiodothyronine (t4) Pending JPS5791964A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803037858 DE3037858A1 (de) 1980-10-07 1980-10-07 Verfahren zur herstellung von reaktiven, kupplungsfaehigen derivaten der schilddruesenhormone t (pfeil abwaerts)3(pfeil abwaerts) und t (pfeil abwaerts)4(pfeil abwaerts) und deren verwendung

Publications (1)

Publication Number Publication Date
JPS5791964A true JPS5791964A (en) 1982-06-08

Family

ID=6113823

Family Applications (2)

Application Number Title Priority Date Filing Date
JP56158879A Pending JPS5791964A (en) 1980-10-07 1981-10-07 Manufacture of reactive bondable derivatives of thyroid hormone 3,3',5-triiodothyronine (t3) and 3,3',5,5'-tetraiodothyronine (t4)
JP58214242A Pending JPS59160762A (ja) 1980-10-07 1983-11-16 甲状腺ホルモン３，３′，５−トリヨ−ドチロニン（ｔ↓３）および３，３′，５，５′−テトラヨ−ドチロニン（ｔ↓４）の不溶の誘導体の製法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP58214242A Pending JPS59160762A (ja) 1980-10-07 1983-11-16 甲状腺ホルモン３，３′，５−トリヨ−ドチロニン（ｔ↓３）および３，３′，５，５′−テトラヨ−ドチロニン（ｔ↓４）の不溶の誘導体の製法

Country Status (7)

Country Link
US (1) US4423227A (ja)
EP (1) EP0049860B1 (ja)
JP (2) JPS5791964A (ja)
AT (1) ATE9689T1 (ja)
DD (1) DD202145A5 (ja)
DE (2) DE3037858A1 (ja)
IL (1) IL63728A0 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205095A (ja) * 1986-03-04 1987-09-09 Toyo Jozo Co Ltd 新生理活性物質アルドスタチンおよびその製造法
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
EP2428516A1 (en) * 2003-11-19 2012-03-14 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
CA2606499C (en) 2005-05-26 2017-06-13 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
MX2007014501A (es) * 2005-05-26 2008-02-07 Metabasis Therapeutics Inc Tiromimeticos novedosos que contienen acido fosfinico.
WO2018094265A2 (en) 2016-11-21 2018-05-24 Viking Therapeutics, Inc. Method of treating glycogen storage disease
EP3634426A4 (en) 2017-06-05 2021-04-07 Viking Therapeutics, Inc. COMPOSITIONS FOR THE TREATMENT OF FIBROSIS
JP2021518403A (ja) 2018-03-22 2021-08-02 バイキング・セラピューティクス・インコーポレイテッド 化合物の結晶形態及び化合物の結晶形態を生成する方法
CN113563248A (zh) * 2021-07-28 2021-10-29 英科新创（苏州）生物科技有限公司 一种半抗原碘代甲状腺素马来酰亚胺活性偶联试剂的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB652207A (en) * 1948-12-31 1951-04-18 Glaxo Lab Ltd Improvements in or relating to the preparation of thyroxine and its derivatives
US2803654A (en) * 1955-06-24 1957-08-20 Baxter Laboratories Inc Preparation of thyroxine products
US2889364A (en) * 1957-05-03 1959-06-02 Baxter Laboratories Inc Process for producing thyroxine
US3046306A (en) * 1959-06-24 1962-07-24 Warner Lambert Pharmaceutical Process of preparing triiodinated analogs of thyronine
JPS5272284A (en) * 1975-12-12 1977-06-16 Dainippon Pharmaceutical Co Enzymeeimmunoassay reagent
DE2737802A1 (de) * 1977-08-22 1979-03-08 Henning Berlin Gmbh Arzneimittel oder diagnostikum zur behandlung oder feststellung von schilddruesenfunktionsstoerungen und verfahren zu dessen herstellung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANGEWANDTE CHEMIE *

Also Published As

Publication number Publication date
IL63728A0 (en) 1981-12-31
ATE9689T1 (de) 1984-10-15
US4423227A (en) 1983-12-27
DD202145A5 (de) 1983-08-31
JPS59160762A (ja) 1984-09-11
DE3037858A1 (de) 1982-05-19
DE3166501D1 (en) 1984-11-08
EP0049860B1 (de) 1984-10-03
EP0049860A1 (de) 1982-04-21

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