JPS5780320A - Cardiotonic agent - Google Patents
Cardiotonic agentInfo
- Publication number
- JPS5780320A JPS5780320A JP15612380A JP15612380A JPS5780320A JP S5780320 A JPS5780320 A JP S5780320A JP 15612380 A JP15612380 A JP 15612380A JP 15612380 A JP15612380 A JP 15612380A JP S5780320 A JPS5780320 A JP S5780320A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- activity
- cardiotonic agent
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare a low-toxic cardiotonic agent having positively inotropic activity and coronary blood stream increasing activity, and useful as remedy for the cardiac diseases such as congestive heart, by using a carbostyril derivative including novel compound as an active component.
CONSTITUTION: A cardiotonic agent containing a carbostyril derivative of formula 1 (R is H, lower alkyl, etc.; A is lower alkylene; X is halogen; the C-C bond between the 3-and the 4-positions of the carbostryril skeleton is single or double), e.g. 6-(3-pyridiniumpropoxy)-3,4-dihydrocarbostyril bromide, as an active component. The compound has excellent positively inotropic activity and coronary blood stream increasing activity, and extremely weak effect to the increase in heart rate. The compound of formula 1 can be obtained by reacting the compound of formula 2 with the compound of formula 3 (X' is halogen, etc.), and then reacting the resultant compound of formula 4 with the compound of formula 5.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15612380A JPS5780320A (en) | 1980-11-05 | 1980-11-05 | Cardiotonic agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15612380A JPS5780320A (en) | 1980-11-05 | 1980-11-05 | Cardiotonic agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5780320A true JPS5780320A (en) | 1982-05-19 |
JPS6254404B2 JPS6254404B2 (en) | 1987-11-14 |
Family
ID=15620818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15612380A Granted JPS5780320A (en) | 1980-11-05 | 1980-11-05 | Cardiotonic agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5780320A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07117552A (en) * | 1993-10-20 | 1995-05-09 | Bunichi Yokoyama | Motor truck for carrying heavy cargo |
-
1980
- 1980-11-05 JP JP15612380A patent/JPS5780320A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07117552A (en) * | 1993-10-20 | 1995-05-09 | Bunichi Yokoyama | Motor truck for carrying heavy cargo |
Also Published As
Publication number | Publication date |
---|---|
JPS6254404B2 (en) | 1987-11-14 |
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