JPS5780320A - Cardiotonic agent - Google Patents

Cardiotonic agent

Info

Publication number
JPS5780320A
JPS5780320A JP15612380A JP15612380A JPS5780320A JP S5780320 A JPS5780320 A JP S5780320A JP 15612380 A JP15612380 A JP 15612380A JP 15612380 A JP15612380 A JP 15612380A JP S5780320 A JPS5780320 A JP S5780320A
Authority
JP
Japan
Prior art keywords
compound
formula
activity
cardiotonic agent
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15612380A
Other languages
Japanese (ja)
Other versions
JPS6254404B2 (en
Inventor
Michiaki Tominaga
Nagao Yo
Hidenori Ogawa
Takao Nishi
Takashi Ueda
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP15612380A priority Critical patent/JPS5780320A/en
Publication of JPS5780320A publication Critical patent/JPS5780320A/en
Publication of JPS6254404B2 publication Critical patent/JPS6254404B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To prepare a low-toxic cardiotonic agent having positively inotropic activity and coronary blood stream increasing activity, and useful as remedy for the cardiac diseases such as congestive heart, by using a carbostyril derivative including novel compound as an active component.
CONSTITUTION: A cardiotonic agent containing a carbostyril derivative of formula 1 (R is H, lower alkyl, etc.; A is lower alkylene; X is halogen; the C-C bond between the 3-and the 4-positions of the carbostryril skeleton is single or double), e.g. 6-(3-pyridiniumpropoxy)-3,4-dihydrocarbostyril bromide, as an active component. The compound has excellent positively inotropic activity and coronary blood stream increasing activity, and extremely weak effect to the increase in heart rate. The compound of formula 1 can be obtained by reacting the compound of formula 2 with the compound of formula 3 (X' is halogen, etc.), and then reacting the resultant compound of formula 4 with the compound of formula 5.
COPYRIGHT: (C)1982,JPO&Japio
JP15612380A 1980-11-05 1980-11-05 Cardiotonic agent Granted JPS5780320A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15612380A JPS5780320A (en) 1980-11-05 1980-11-05 Cardiotonic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15612380A JPS5780320A (en) 1980-11-05 1980-11-05 Cardiotonic agent

Publications (2)

Publication Number Publication Date
JPS5780320A true JPS5780320A (en) 1982-05-19
JPS6254404B2 JPS6254404B2 (en) 1987-11-14

Family

ID=15620818

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15612380A Granted JPS5780320A (en) 1980-11-05 1980-11-05 Cardiotonic agent

Country Status (1)

Country Link
JP (1) JPS5780320A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07117552A (en) * 1993-10-20 1995-05-09 Bunichi Yokoyama Motor truck for carrying heavy cargo

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07117552A (en) * 1993-10-20 1995-05-09 Bunichi Yokoyama Motor truck for carrying heavy cargo

Also Published As

Publication number Publication date
JPS6254404B2 (en) 1987-11-14

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