JPS5775957A - Peptide derivative - Google Patents

Peptide derivative

Info

Publication number
JPS5775957A
JPS5775957A JP55151610A JP15161080A JPS5775957A JP S5775957 A JPS5775957 A JP S5775957A JP 55151610 A JP55151610 A JP 55151610A JP 15161080 A JP15161080 A JP 15161080A JP S5775957 A JPS5775957 A JP S5775957A
Authority
JP
Japan
Prior art keywords
protecting
amino
methylcoumarin
lysine
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55151610A
Other languages
Japanese (ja)
Inventor
Setsuo Fujii
Ryoji Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii Pharmaceutical Co Ltd
Original Assignee
Torii Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii Pharmaceutical Co Ltd filed Critical Torii Pharmaceutical Co Ltd
Priority to JP55151610A priority Critical patent/JPS5775957A/en
Publication of JPS5775957A publication Critical patent/JPS5775957A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A compound shown by the formula (R is H or amino-protecting group).
EXAMPLE: 7-(Nα-t-Butyloxycarbonyl-L-glutaminyl-Nε-carbobenzoxy-L-lysyl-Nσ,ω- dicarbobenzoxy-L-arginyl-Nε-carbobenzoxy-L-lysyl)amino-4-methylcoumarin.
USE: A substrate for enzyme. Useful for highly sensitive measurement, e.g., titer, purity, etc. of enzyme.
PROCESS: Nα-And Nε-protecting lysine is condensed through dehydration with 7- amino-4-methylcoumarin, and Nα protecting group is removed selectively. The prepared Nε-protecting lysine-4-methylcoumarin derivative is condensed through dehydration with a side chain- and Nα-protecting arginine, Nα- and Nε-protecting lysine and Nα-protecting glutamic acid successively. The side chain-protecting group is removed selectively, to give a compound shown by the formula. The reaction is preferably carried out at from 0°CW room temperature in a solvent, e.g., DMF, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP55151610A 1980-10-29 1980-10-29 Peptide derivative Pending JPS5775957A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55151610A JPS5775957A (en) 1980-10-29 1980-10-29 Peptide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55151610A JPS5775957A (en) 1980-10-29 1980-10-29 Peptide derivative

Publications (1)

Publication Number Publication Date
JPS5775957A true JPS5775957A (en) 1982-05-12

Family

ID=15522290

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55151610A Pending JPS5775957A (en) 1980-10-29 1980-10-29 Peptide derivative

Country Status (1)

Country Link
JP (1) JPS5775957A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087120A (en) * 1996-02-02 2000-07-11 Haemoprobe B.V. Measurement of complement activation by biomaterials by means of complement convertase cleavage of peptide substrates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087120A (en) * 1996-02-02 2000-07-11 Haemoprobe B.V. Measurement of complement activation by biomaterials by means of complement convertase cleavage of peptide substrates

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