JPS577471A - Novel 2,4 1h,3h -quinazolinedione derivative - Google Patents

Novel 2,4 1h,3h -quinazolinedione derivative

Info

Publication number
JPS577471A
JPS577471A JP8084380A JP8084380A JPS577471A JP S577471 A JPS577471 A JP S577471A JP 8084380 A JP8084380 A JP 8084380A JP 8084380 A JP8084380 A JP 8084380A JP S577471 A JPS577471 A JP S577471A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
alkyl
benzyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8084380A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Akiko Sugimoto
Masao Eguchi
Fujinori Sasaki
Katsuhiko Goto
Soyao Moriguchi
Hisashi Ebisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP8084380A priority Critical patent/JPS577471A/en
Priority to CA000377591A priority patent/CA1161036A/en
Priority to US06/263,898 priority patent/US4405623A/en
Priority to AU70625/81A priority patent/AU547554B2/en
Priority to EP19810103838 priority patent/EP0040793B1/en
Priority to DE8181103838T priority patent/DE3172006D1/en
Publication of JPS577471A publication Critical patent/JPS577471A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I [R1 and R3 are lower alkyl; R2 is alkoxycarbonyl; R1, R2 and R3 are linked to the 5W7 or the 6W8 -positions of the quinazoline nucleus; X is alkylene; R5 is H or alkyl; R6 is R5, phenyl, benzyl or formula II (Y is the same as X; R7 is alkyl; R8 is R7 or benzyl, R7 and R8 together with the nitrogen atom form a pyrrolidine ring, etc.); R4 is H, halogen, alkyl, etc.].
EXAMPLE: 1-[ 2-(N,N-Diethylamino)ethyl ]aminocarbonylmethyl-6-ethoxycarbonyl- 5,7-dimethyl-3-(o-chlorophenyl)-2,4(1H,3H)-quinazolinedione.
USE: A vasodilator, an ameliorant of blood flow, a hypotensive agent or antiarteriosclerotic agent.
PROCESS: A compound expressed by formula III is reacted with a compound expressed by formula IV (Z is halogen) in the presence of an alkali metallic hydride or alkali metallic amide to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8084380A 1980-05-15 1980-06-17 Novel 2,4 1h,3h -quinazolinedione derivative Pending JPS577471A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP8084380A JPS577471A (en) 1980-06-17 1980-06-17 Novel 2,4 1h,3h -quinazolinedione derivative
CA000377591A CA1161036A (en) 1980-05-15 1981-05-14 Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
US06/263,898 US4405623A (en) 1980-05-15 1981-05-15 Quinazolinde-dione compounds, process for production thereof and pharmaceutical use thereof
AU70625/81A AU547554B2 (en) 1980-05-15 1981-05-15 2,4(1h,3h)-quinazoline diones
EP19810103838 EP0040793B1 (en) 1980-05-22 1981-05-19 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
DE8181103838T DE3172006D1 (en) 1980-05-22 1981-05-19 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8084380A JPS577471A (en) 1980-06-17 1980-06-17 Novel 2,4 1h,3h -quinazolinedione derivative

Publications (1)

Publication Number Publication Date
JPS577471A true JPS577471A (en) 1982-01-14

Family

ID=13729631

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8084380A Pending JPS577471A (en) 1980-05-15 1980-06-17 Novel 2,4 1h,3h -quinazolinedione derivative

Country Status (1)

Country Link
JP (1) JPS577471A (en)

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