JPS5714580A - Novel 2,4 1h, 3h -quinazolinedione derivative - Google Patents
Novel 2,4 1h, 3h -quinazolinedione derivativeInfo
- Publication number
- JPS5714580A JPS5714580A JP8771580A JP8771580A JPS5714580A JP S5714580 A JPS5714580 A JP S5714580A JP 8771580 A JP8771580 A JP 8771580A JP 8771580 A JP8771580 A JP 8771580A JP S5714580 A JPS5714580 A JP S5714580A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- quinazolinedione
- formula
- benzyl
- positions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2,4(1H,3H)-quinazolinedione derivative expressed by formula I (R1 and R3 are alkyl; R2 is alkoxycarbonyl, and R1, R2 and R3 are linked to the 5-, 6- and 7-positions or 6-, 7- and 8-positions of the quinazoline nucleus; X is alkylene which may have an alkyl side chain; R4 is alkyl; R5 is benzyl; R6 is H, halogen, alkyl, trifluoromethyl or nitro).
EXAMPLE: 6-Ethoxycarbonyl-5,7-dimethyl-1-[3-(N-benzyl-N-methylamino)propyl] 3-(o-chlorophenyl)-2,4(1H,3H)-quinazolinedione.
USE: A vasodilator, an ameliorant of blood flow, a hypotensive agent, and an antiarteriosclerotic agent having a long duration of action.
PROCESS: A compound expressed by formula II is reacted with a compound expressed by formula III in the presence of an alkaline metallic hydride or alkaline metallic amide.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8771580A JPS5714580A (en) | 1980-06-30 | 1980-06-30 | Novel 2,4 1h, 3h -quinazolinedione derivative |
CA000377591A CA1161036A (en) | 1980-05-15 | 1981-05-14 | Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
US06/263,898 US4405623A (en) | 1980-05-15 | 1981-05-15 | Quinazolinde-dione compounds, process for production thereof and pharmaceutical use thereof |
AU70625/81A AU547554B2 (en) | 1980-05-15 | 1981-05-15 | 2,4(1h,3h)-quinazoline diones |
DE8181103838T DE3172006D1 (en) | 1980-05-22 | 1981-05-19 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
EP19810103838 EP0040793B1 (en) | 1980-05-22 | 1981-05-19 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8771580A JPS5714580A (en) | 1980-06-30 | 1980-06-30 | Novel 2,4 1h, 3h -quinazolinedione derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5714580A true JPS5714580A (en) | 1982-01-25 |
Family
ID=13922593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8771580A Pending JPS5714580A (en) | 1980-05-15 | 1980-06-30 | Novel 2,4 1h, 3h -quinazolinedione derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5714580A (en) |
-
1980
- 1980-06-30 JP JP8771580A patent/JPS5714580A/en active Pending
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