JPS5714580A - Novel 2,4 1h, 3h -quinazolinedione derivative - Google Patents

Novel 2,4 1h, 3h -quinazolinedione derivative

Info

Publication number
JPS5714580A
JPS5714580A JP8771580A JP8771580A JPS5714580A JP S5714580 A JPS5714580 A JP S5714580A JP 8771580 A JP8771580 A JP 8771580A JP 8771580 A JP8771580 A JP 8771580A JP S5714580 A JPS5714580 A JP S5714580A
Authority
JP
Japan
Prior art keywords
alkyl
quinazolinedione
formula
benzyl
positions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8771580A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Akiko Sugimoto
Masao Eguchi
Fujinori Sasaki
Katsuhiko Goto
Soyao Moriguchi
Hisashi Ebisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP8771580A priority Critical patent/JPS5714580A/en
Priority to CA000377591A priority patent/CA1161036A/en
Priority to US06/263,898 priority patent/US4405623A/en
Priority to AU70625/81A priority patent/AU547554B2/en
Priority to DE8181103838T priority patent/DE3172006D1/en
Priority to EP19810103838 priority patent/EP0040793B1/en
Publication of JPS5714580A publication Critical patent/JPS5714580A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 2,4(1H,3H)-quinazolinedione derivative expressed by formula I (R1 and R3 are alkyl; R2 is alkoxycarbonyl, and R1, R2 and R3 are linked to the 5-, 6- and 7-positions or 6-, 7- and 8-positions of the quinazoline nucleus; X is alkylene which may have an alkyl side chain; R4 is alkyl; R5 is benzyl; R6 is H, halogen, alkyl, trifluoromethyl or nitro).
EXAMPLE: 6-Ethoxycarbonyl-5,7-dimethyl-1-[3-(N-benzyl-N-methylamino)propyl] 3-(o-chlorophenyl)-2,4(1H,3H)-quinazolinedione.
USE: A vasodilator, an ameliorant of blood flow, a hypotensive agent, and an antiarteriosclerotic agent having a long duration of action.
PROCESS: A compound expressed by formula II is reacted with a compound expressed by formula III in the presence of an alkaline metallic hydride or alkaline metallic amide.
COPYRIGHT: (C)1982,JPO&Japio
JP8771580A 1980-05-15 1980-06-30 Novel 2,4 1h, 3h -quinazolinedione derivative Pending JPS5714580A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP8771580A JPS5714580A (en) 1980-06-30 1980-06-30 Novel 2,4 1h, 3h -quinazolinedione derivative
CA000377591A CA1161036A (en) 1980-05-15 1981-05-14 Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
US06/263,898 US4405623A (en) 1980-05-15 1981-05-15 Quinazolinde-dione compounds, process for production thereof and pharmaceutical use thereof
AU70625/81A AU547554B2 (en) 1980-05-15 1981-05-15 2,4(1h,3h)-quinazoline diones
DE8181103838T DE3172006D1 (en) 1980-05-22 1981-05-19 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
EP19810103838 EP0040793B1 (en) 1980-05-22 1981-05-19 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8771580A JPS5714580A (en) 1980-06-30 1980-06-30 Novel 2,4 1h, 3h -quinazolinedione derivative

Publications (1)

Publication Number Publication Date
JPS5714580A true JPS5714580A (en) 1982-01-25

Family

ID=13922593

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8771580A Pending JPS5714580A (en) 1980-05-15 1980-06-30 Novel 2,4 1h, 3h -quinazolinedione derivative

Country Status (1)

Country Link
JP (1) JPS5714580A (en)

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