JPS57197269A - Novel 2,4-(1h,3h)-quinazolinedione derivative - Google Patents
Novel 2,4-(1h,3h)-quinazolinedione derivativeInfo
- Publication number
- JPS57197269A JPS57197269A JP8007281A JP8007281A JPS57197269A JP S57197269 A JPS57197269 A JP S57197269A JP 8007281 A JP8007281 A JP 8007281A JP 8007281 A JP8007281 A JP 8007281A JP S57197269 A JPS57197269 A JP S57197269A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- halogen
- compound
- quinazolinedione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2,4(1H,3H)-quinazolinedione derivative of formulaI[R1, R3 are lower alkyl; R2 is alkoxycarbonyl, and R1, R2, R3 are bonded to the 5, 6, and 7 or 6, 7, and 8 positions on the quinazoline ring; R4 is formula II (R6, R7 are H, alkyl, alkoxy, or incorporate to form methylenedioxy; R8 is H, halogen, alkyl), formula III; R5 is alkyl, formula IV (R9, R10 are H, halogen, trifluoromethyl, nitro)].
EXAMPLE: 1-Benzyl-6-ethoxycarbonyl-3,5,7-trimethyl-2,4(1H,3H)-quinazolinedione.
USE: Vasodilator, blood streamer improver, antihypertensive, antiarteriosclerotic.
PREPARATION: A compound of R4-Z (Z is halogen) is made to act on a compound of formula V in the presence of an alkali hydride to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8007281A JPS57197269A (en) | 1981-05-28 | 1981-05-28 | Novel 2,4-(1h,3h)-quinazolinedione derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8007281A JPS57197269A (en) | 1981-05-28 | 1981-05-28 | Novel 2,4-(1h,3h)-quinazolinedione derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57197269A true JPS57197269A (en) | 1982-12-03 |
Family
ID=13708009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8007281A Pending JPS57197269A (en) | 1981-05-28 | 1981-05-28 | Novel 2,4-(1h,3h)-quinazolinedione derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57197269A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617392A (en) * | 1983-09-29 | 1986-10-14 | Ortho Pharmaceutical Corporation | 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents |
US5015740A (en) * | 1988-08-05 | 1991-05-14 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
-
1981
- 1981-05-28 JP JP8007281A patent/JPS57197269A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617392A (en) * | 1983-09-29 | 1986-10-14 | Ortho Pharmaceutical Corporation | 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents |
US5015740A (en) * | 1988-08-05 | 1991-05-14 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
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