JPS57197269A - Novel 2,4-(1h,3h)-quinazolinedione derivative - Google Patents

Novel 2,4-(1h,3h)-quinazolinedione derivative

Info

Publication number
JPS57197269A
JPS57197269A JP8007281A JP8007281A JPS57197269A JP S57197269 A JPS57197269 A JP S57197269A JP 8007281 A JP8007281 A JP 8007281A JP 8007281 A JP8007281 A JP 8007281A JP S57197269 A JPS57197269 A JP S57197269A
Authority
JP
Japan
Prior art keywords
formula
alkyl
halogen
compound
quinazolinedione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8007281A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Akiko Sugimoto
Masao Eguchi
Fujinori Sasaki
Katsuhiko Goto
Soyao Moriguchi
Hisashi Ebisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP8007281A priority Critical patent/JPS57197269A/en
Publication of JPS57197269A publication Critical patent/JPS57197269A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 2,4(1H,3H)-quinazolinedione derivative of formulaI[R1, R3 are lower alkyl; R2 is alkoxycarbonyl, and R1, R2, R3 are bonded to the 5, 6, and 7 or 6, 7, and 8 positions on the quinazoline ring; R4 is formula II (R6, R7 are H, alkyl, alkoxy, or incorporate to form methylenedioxy; R8 is H, halogen, alkyl), formula III; R5 is alkyl, formula IV (R9, R10 are H, halogen, trifluoromethyl, nitro)].
EXAMPLE: 1-Benzyl-6-ethoxycarbonyl-3,5,7-trimethyl-2,4(1H,3H)-quinazolinedione.
USE: Vasodilator, blood streamer improver, antihypertensive, antiarteriosclerotic.
PREPARATION: A compound of R4-Z (Z is halogen) is made to act on a compound of formula V in the presence of an alkali hydride to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP8007281A 1981-05-28 1981-05-28 Novel 2,4-(1h,3h)-quinazolinedione derivative Pending JPS57197269A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8007281A JPS57197269A (en) 1981-05-28 1981-05-28 Novel 2,4-(1h,3h)-quinazolinedione derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8007281A JPS57197269A (en) 1981-05-28 1981-05-28 Novel 2,4-(1h,3h)-quinazolinedione derivative

Publications (1)

Publication Number Publication Date
JPS57197269A true JPS57197269A (en) 1982-12-03

Family

ID=13708009

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8007281A Pending JPS57197269A (en) 1981-05-28 1981-05-28 Novel 2,4-(1h,3h)-quinazolinedione derivative

Country Status (1)

Country Link
JP (1) JPS57197269A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617392A (en) * 1983-09-29 1986-10-14 Ortho Pharmaceutical Corporation 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617392A (en) * 1983-09-29 1986-10-14 Ortho Pharmaceutical Corporation 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives

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