JPS5735591A - Novel pyrimidine derivative - Google Patents

Novel pyrimidine derivative

Info

Publication number
JPS5735591A
JPS5735591A JP11070880A JP11070880A JPS5735591A JP S5735591 A JPS5735591 A JP S5735591A JP 11070880 A JP11070880 A JP 11070880A JP 11070880 A JP11070880 A JP 11070880A JP S5735591 A JPS5735591 A JP S5735591A
Authority
JP
Japan
Prior art keywords
diethylamino
nitropyrimidine
methyl
formula
amino group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11070880A
Other languages
Japanese (ja)
Other versions
JPS6346756B2 (en
Inventor
Haruo Onishi
Koji Kojiyaku
Yasuo Suzuki
Suguru Mochida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Priority to JP11070880A priority Critical patent/JPS5735591A/en
Publication of JPS5735591A publication Critical patent/JPS5735591A/en
Publication of JPS6346756B2 publication Critical patent/JPS6346756B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of the formula (X is O, S, alkyl, ω-carboxyalkyl- substituted N).
EXAMPLE: 7-Diethylamino-5-methyloxazolo[5,4-d]pyrimidine.
USE: A remedy for cardiovascular system disorders: they have vasodilative, hypotensive, blood platelet coagulation-inhibiting and cholesterol-depressing activities. They are soluble in water.
PREPARATION: 4-Diethylamino-6-hydroxy-2-methyl-5-nitropyrimidine or 4-diethylamino-6-mercapto-2-methyl-5-nitropyrimidine is reduced by a known method to convert the nitro group into an amino group and produce an aminopyrimidine derivative. Then, formic acid is used to effect direct cyclization or to effect the formylation of the amino group, followed by cyclization with phosphorous oxychloride or phosphorous trichloride to give the compound of the formula.
COPYRIGHT: (C)1982,JPO&Japio
JP11070880A 1980-08-12 1980-08-12 Novel pyrimidine derivative Granted JPS5735591A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11070880A JPS5735591A (en) 1980-08-12 1980-08-12 Novel pyrimidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11070880A JPS5735591A (en) 1980-08-12 1980-08-12 Novel pyrimidine derivative

Publications (2)

Publication Number Publication Date
JPS5735591A true JPS5735591A (en) 1982-02-26
JPS6346756B2 JPS6346756B2 (en) 1988-09-19

Family

ID=14542441

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11070880A Granted JPS5735591A (en) 1980-08-12 1980-08-12 Novel pyrimidine derivative

Country Status (1)

Country Link
JP (1) JPS5735591A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476127A (en) * 1982-02-19 1984-10-09 Mochida Pharmaceutical Co., Ltd. 7-Diethylamino-5-methyl-thiazolo[5,4-d]pyrimidine and pharmaceutical composition containing same
DE4003388A1 (en) * 1989-02-06 1990-08-16 Fuji Electric Co Ltd MOS SEMICONDUCTOR DEVICE
US5115287A (en) * 1986-11-19 1992-05-19 Research Development Corporation Of Japan Step-cut insulated gate static induction transistors and method of manufacturing the same
US5300509A (en) * 1991-11-25 1994-04-05 Imperial Chemical Industries Plc 2-furyl-oxazolo[5,4-d]-pyrimidines

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476127A (en) * 1982-02-19 1984-10-09 Mochida Pharmaceutical Co., Ltd. 7-Diethylamino-5-methyl-thiazolo[5,4-d]pyrimidine and pharmaceutical composition containing same
US5115287A (en) * 1986-11-19 1992-05-19 Research Development Corporation Of Japan Step-cut insulated gate static induction transistors and method of manufacturing the same
DE4003388A1 (en) * 1989-02-06 1990-08-16 Fuji Electric Co Ltd MOS SEMICONDUCTOR DEVICE
US5021846A (en) * 1989-02-06 1991-06-04 Fuji Electric Co., Ltd. MOS semiconductor device with an inverted U-shaped gate
US5300509A (en) * 1991-11-25 1994-04-05 Imperial Chemical Industries Plc 2-furyl-oxazolo[5,4-d]-pyrimidines
US5500428A (en) * 1991-11-25 1996-03-19 Imperial Chemical Industries Plc Furyl-substituted purines and adenosine antagonists

Also Published As

Publication number Publication date
JPS6346756B2 (en) 1988-09-19

Similar Documents

Publication Publication Date Title
IL99571A (en) Process for the preparation of water soluble 10-hydroxy-9-(substituted methyl)camptothecin analogs
DK227183A (en) METHOD OF PREPARING IMIDAZO (1,2-C) -PYRAZOLO (3,4-E) PYRIMIDINES OF THE GENERAL FORMULA I
PT80489B (en) PROCESS FOR THE PREPARATION OF NOVEL HETEROCYCLIC DERIVATIVES USEFULLY AS INNIBITORS OF ALDOSE REDUCTASE
JPS5735591A (en) Novel pyrimidine derivative
EP0066909A3 (en) Imidazole derivatives, pharmaceutical compositions containing them and processes for their production
JPS5289681A (en) Preparation of aracytidine -5# phosphoric acid ester derivatives
JPS5259191A (en) Preparation of 2,6-di(halogenophenoxy)-4,8-dipiperidinopyrimido 5,4-d pyrimidines
JPS55147295A (en) Preparation of diphosphoglyceric acid salt
JPS56127383A (en) Preparation of s-triazolo- 1,5-a -pyrimidine derivative
JPS5353695A (en) Preparation of pyrimido 5,4-d pyrimidine derivatives
JPS53116376A (en) Preparation of chromone derivatives
JPS5344591A (en) Preparation of adenine derivatives
ES512966A0 (en) "PROCEDURE FOR PREPARING SULFIMIDE DERIVATIVES OF N-CARBAMOILBENZOIC ACID".
JPS56150072A (en) Novel quinazoline derivative and its preparation
JPS5538361A (en) 6-hydroxymethylpyrido 2,3-d pyrimidine derivative and its preparation
JPS51146497A (en) Process for preparing pyrido (1,2-a)pyrimidinone derivatives
JPS5356695A (en) Pyridobenzoazepines and their preparation
JPS5344597A (en) Condensed quinazolinol derivative
JPS5663972A (en) Preparation of novel benzothiazolone derivative containing novel heterocyclic quaternary salt
JPS543059A (en) Preparation of tryptophane
JPS5735592A (en) Novel s-triazolo(1,5-a) pyrimidine derivative
JPS51136695A (en) Process for preparing new pyrimido(4,5-d)pyrimidine derivatives
JPS5424877A (en) Novel preparation of 2-aminonicotinic acid derivatives
JPS52122387A (en) 7alpha-methoxycephalosporin derivatives and their preparation
JPS5414961A (en) Novel 3-hydroxyazetidine-3-carboxylic derivative