JPS5735592A - Novel s-triazolo(1,5-a) pyrimidine derivative - Google Patents
Novel s-triazolo(1,5-a) pyrimidine derivativeInfo
- Publication number
- JPS5735592A JPS5735592A JP11070980A JP11070980A JPS5735592A JP S5735592 A JPS5735592 A JP S5735592A JP 11070980 A JP11070980 A JP 11070980A JP 11070980 A JP11070980 A JP 11070980A JP S5735592 A JPS5735592 A JP S5735592A
- Authority
- JP
- Japan
- Prior art keywords
- triazolo
- branched
- phenyl
- alkyl
- straight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Compounds of the formula (R1, R2 are straight or branched 1W 6C alkyl, phenyl, H; R3 is straight, branched 1W6C alkyl, H; R4 is straight or branched 1W6C alkyl, phenyl).
EXAMPLE: 7-Diethylamino-5-methyl-2-(N-phenyl-N-propyl)aminomethyl-s-triazolo [1,5-a]pyrimidine.
USE: A remedy for cardiovacular system disorders: they have vasodilative, hypotensive, blood platelet coagulation-inhibiting and cholesterol-depressing activities.
PREPARATION: The thermal condensation reaction between 3-amino-5-hydroxymethyl-s-triazole and an -acylcaroxylic ester gives 2-hydroxymethyl-7-hydroxy-s- triazolo[1,5-a]pyrimidine derivative. Then, the prduct is halogenated with a halogenating agent and made to react with an amine to produce the compound of the formula.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11070980A JPS5735592A (en) | 1980-08-12 | 1980-08-12 | Novel s-triazolo(1,5-a) pyrimidine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11070980A JPS5735592A (en) | 1980-08-12 | 1980-08-12 | Novel s-triazolo(1,5-a) pyrimidine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5735592A true JPS5735592A (en) | 1982-02-26 |
JPS6232750B2 JPS6232750B2 (en) | 1987-07-16 |
Family
ID=14542465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11070980A Granted JPS5735592A (en) | 1980-08-12 | 1980-08-12 | Novel s-triazolo(1,5-a) pyrimidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5735592A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1983002944A1 (en) * | 1982-02-19 | 1983-09-01 | Ohnishi, Haruo | NOVEL s-TRIAZOLEAD1,5-aBDPYRIMIDINE DERIVATIVES |
-
1980
- 1980-08-12 JP JP11070980A patent/JPS5735592A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1983002944A1 (en) * | 1982-02-19 | 1983-09-01 | Ohnishi, Haruo | NOVEL s-TRIAZOLEAD1,5-aBDPYRIMIDINE DERIVATIVES |
EP0101517A1 (en) * | 1982-02-19 | 1984-02-29 | Mochida Pharmaceutical Co., Ltd. | NOVEL s-TRIAZOLE(1,5-a)PYRIMIDINE DERIVATIVES |
Also Published As
Publication number | Publication date |
---|---|
JPS6232750B2 (en) | 1987-07-16 |
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