JPS5773000A - Production of olean-1-2ene-3beta,30-diol - Google Patents

Production of olean-1-2ene-3beta,30-diol

Info

Publication number
JPS5773000A
JPS5773000A JP14841280A JP14841280A JPS5773000A JP S5773000 A JPS5773000 A JP S5773000A JP 14841280 A JP14841280 A JP 14841280A JP 14841280 A JP14841280 A JP 14841280A JP S5773000 A JPS5773000 A JP S5773000A
Authority
JP
Japan
Prior art keywords
olean
ene
acid
triol
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14841280A
Other languages
Japanese (ja)
Other versions
JPS6118536B2 (en
Inventor
Shoji Shibata
Kunio Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MINOFUAAGEN SEIYAKU HONPO KK
Minophagen Pharmaceutical Co Ltd
Original Assignee
MINOFUAAGEN SEIYAKU HONPO KK
Minophagen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MINOFUAAGEN SEIYAKU HONPO KK, Minophagen Pharmaceutical Co Ltd filed Critical MINOFUAAGEN SEIYAKU HONPO KK
Priority to JP14841280A priority Critical patent/JPS5773000A/en
Priority to DE19813111522 priority patent/DE3111522A1/en
Priority to US06/248,222 priority patent/US4374284A/en
Priority to IT819373A priority patent/IT1167857B/en
Priority to GB8110193A priority patent/GB2075835B/en
Publication of JPS5773000A publication Critical patent/JPS5773000A/en
Priority to GB08324020A priority patent/GB2134525B/en
Publication of JPS6118536B2 publication Critical patent/JPS6118536B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: Glycyrrhetinic acid (olean-12-ene-11-oxo-3β-ol-30-oic acid) is reduced and the product is subjected to catalystic hydrogenation to produce the titled compound used as an anti-inflammatory or antiallergic with industrial advantage.
CONSTITUTION: Glycyrrhetinic acid of formulaI(olean-12-ene-11-oxo-3β-ol-30-oic acid) is reduced, (A) straight by use of bis (2-methoxyethoxy)aluminum sodium hydride, (B) by methyl esterification of glycyrrhitinic acid with a diazomthane solution before the reduction with sodium aluminum hydride to prepare a triol of formula II (olean-12-ene-3β-11ξ,30-triol). The product is subjected to catalytic reduction in the presence of Pd/C catalyst to produce the objective compound of formula III.
EFFECT: The objective compound is obtained in high yield by no use of expensive platinum catalyst.
COPYRIGHT: (C)1982,JPO&Japio
JP14841280A 1980-04-01 1980-10-24 Production of olean-1-2ene-3beta,30-diol Granted JPS5773000A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP14841280A JPS5773000A (en) 1980-10-24 1980-10-24 Production of olean-1-2ene-3beta,30-diol
DE19813111522 DE3111522A1 (en) 1980-04-01 1981-03-24 MEDICINE WITH ANTIULCUS EFFECT, ANTI-INFLAMMATORY AND ANTIALLERGIC EFFECT
US06/248,222 US4374284A (en) 1980-04-01 1981-03-27 Antiulcer, antiinflammatory, and antiallergic agent comprising as the main ingredient olean-12-ene-3β, 30-diol which is devoid of side effects of glycyrrhetinic acid and a new process for preparation of olean-12-ene-3β, 30-diol
IT819373A IT1167857B (en) 1980-04-01 1981-03-31 ANTI-ULCER, ANTI-INFLAMMATORY AND ANTI-ALLERGIC AGENT INCLUDING AS MAIN INGREDIENT OLEAN-12-ENE-3BETA, 30-DIOL AND PREPARATION OF IT
GB8110193A GB2075835B (en) 1980-04-01 1981-04-01 A pharmacological composition comprising and olean-12-ene 3 30 diol or an ester thereof and a process for preparing said compound
GB08324020A GB2134525B (en) 1980-04-01 1983-09-07 Preparation of olean-12-ene-3b 30-diol and esters thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14841280A JPS5773000A (en) 1980-10-24 1980-10-24 Production of olean-1-2ene-3beta,30-diol

Publications (2)

Publication Number Publication Date
JPS5773000A true JPS5773000A (en) 1982-05-07
JPS6118536B2 JPS6118536B2 (en) 1986-05-13

Family

ID=15452207

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14841280A Granted JPS5773000A (en) 1980-04-01 1980-10-24 Production of olean-1-2ene-3beta,30-diol

Country Status (1)

Country Link
JP (1) JPS5773000A (en)

Also Published As

Publication number Publication date
JPS6118536B2 (en) 1986-05-13

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