JPS5768794A - Preparation of nucleoside-5'-carboxylic acids - Google Patents

Preparation of nucleoside-5'-carboxylic acids

Info

Publication number
JPS5768794A
JPS5768794A JP14406480A JP14406480A JPS5768794A JP S5768794 A JPS5768794 A JP S5768794A JP 14406480 A JP14406480 A JP 14406480A JP 14406480 A JP14406480 A JP 14406480A JP S5768794 A JPS5768794 A JP S5768794A
Authority
JP
Japan
Prior art keywords
nucleoside
oxidase
adenosine
aqueous medium
aerobic conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14406480A
Other languages
Japanese (ja)
Inventor
Hideo Misaki
Shigeru Ikuta
Kazuo Matsuura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP14406480A priority Critical patent/JPS5768794A/en
Priority to DE3153683A priority patent/DE3153683C2/de
Priority to FR8115519A priority patent/FR2488618A1/en
Priority to DE19813132121 priority patent/DE3132121A1/en
Priority to CA000383582A priority patent/CA1173767A/en
Priority to NLAANVRAGE8103787,A priority patent/NL187273C/en
Priority to GB8124708A priority patent/GB2087401B/en
Priority to IT23478/81A priority patent/IT1168159B/en
Priority to US06/292,154 priority patent/US4385112A/en
Publication of JPS5768794A publication Critical patent/JPS5768794A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To obtain the titled substance simply, by treating a novel nucleoside oxidase with a nucleoside, e.g., adenosine, guanosine, etc. under aerobic conditions in an aqueous medium.
CONSTITUTION: A bacterium capable of producing nucleoside oxidase, e.g., Pseudomonas putida B-0781 (FERM-P 5664), etc. is cultivated conventionally to give a culture mold, from which nucleoside oxidase is prepared by lysozyme treatment, ultrasonic treatment, etc. A 5'-hydroxymethyl group-containing nucleoside, e.g., adenosine, thymidine, cythidine, etc. as a raw material is treated with the above- mentioned nucleoside oxidase in an aqueous medium under aerobic conditions, to form a nucleoside-5'-carboxylic acid. the prepared reaction solution is adjusted to a pH of about 2W3, the desired substance is precipitated, and it is collected and purified by recrystallization, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP14406480A 1980-08-12 1980-10-14 Preparation of nucleoside-5'-carboxylic acids Pending JPS5768794A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP14406480A JPS5768794A (en) 1980-10-14 1980-10-14 Preparation of nucleoside-5'-carboxylic acids
DE3153683A DE3153683C2 (en) 1980-08-12 1981-08-11
FR8115519A FR2488618A1 (en) 1980-08-12 1981-08-11 NOVEL NUCLEOSIDE OXIDASE, METHOD FOR PRODUCING THE SAME AND USE THEREOF
DE19813132121 DE3132121A1 (en) 1980-08-12 1981-08-11 NUCLEOSIDE OXIDASE AND METHOD FOR ITS OBTAINMENT AND USE OF NUCLEOSIDE OXIDASE
CA000383582A CA1173767A (en) 1980-08-12 1981-08-11 Nucleoside oxidase, its production and use
NLAANVRAGE8103787,A NL187273C (en) 1980-08-12 1981-08-12 NUCLEOSIDE OXYDASE, METHOD FOR PREPARING THE SAME, METHOD FOR PREPARING NUCLEOSIDE 5'-CARBONIC ACID, METHOD FOR DETERMINING NUCLEOSIDES IN A LIQUID SAMPLE, AND A REAGENTIACOMPINATION.
GB8124708A GB2087401B (en) 1980-08-12 1981-08-12 Nucleoside oxidase its production and use in determining nucleosides
IT23478/81A IT1168159B (en) 1980-08-12 1981-08-12 NUCLEOSIDE OXIDASE, ITS PRODUCTION AND USE
US06/292,154 US4385112A (en) 1980-08-12 1981-08-12 Nucleoside oxidase and process for making same, and process and kit for using same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14406480A JPS5768794A (en) 1980-10-14 1980-10-14 Preparation of nucleoside-5'-carboxylic acids

Publications (1)

Publication Number Publication Date
JPS5768794A true JPS5768794A (en) 1982-04-27

Family

ID=15353457

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14406480A Pending JPS5768794A (en) 1980-08-12 1980-10-14 Preparation of nucleoside-5'-carboxylic acids

Country Status (1)

Country Link
JP (1) JPS5768794A (en)

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