JPS5768794A - Preparation of nucleoside-5'-carboxylic acids - Google Patents
Preparation of nucleoside-5'-carboxylic acidsInfo
- Publication number
- JPS5768794A JPS5768794A JP14406480A JP14406480A JPS5768794A JP S5768794 A JPS5768794 A JP S5768794A JP 14406480 A JP14406480 A JP 14406480A JP 14406480 A JP14406480 A JP 14406480A JP S5768794 A JPS5768794 A JP S5768794A
- Authority
- JP
- Japan
- Prior art keywords
- nucleoside
- oxidase
- adenosine
- aqueous medium
- aerobic conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To obtain the titled substance simply, by treating a novel nucleoside oxidase with a nucleoside, e.g., adenosine, guanosine, etc. under aerobic conditions in an aqueous medium.
CONSTITUTION: A bacterium capable of producing nucleoside oxidase, e.g., Pseudomonas putida B-0781 (FERM-P 5664), etc. is cultivated conventionally to give a culture mold, from which nucleoside oxidase is prepared by lysozyme treatment, ultrasonic treatment, etc. A 5'-hydroxymethyl group-containing nucleoside, e.g., adenosine, thymidine, cythidine, etc. as a raw material is treated with the above- mentioned nucleoside oxidase in an aqueous medium under aerobic conditions, to form a nucleoside-5'-carboxylic acid. the prepared reaction solution is adjusted to a pH of about 2W3, the desired substance is precipitated, and it is collected and purified by recrystallization, etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14406480A JPS5768794A (en) | 1980-10-14 | 1980-10-14 | Preparation of nucleoside-5'-carboxylic acids |
DE3153683A DE3153683C2 (en) | 1980-08-12 | 1981-08-11 | |
FR8115519A FR2488618A1 (en) | 1980-08-12 | 1981-08-11 | NOVEL NUCLEOSIDE OXIDASE, METHOD FOR PRODUCING THE SAME AND USE THEREOF |
DE19813132121 DE3132121A1 (en) | 1980-08-12 | 1981-08-11 | NUCLEOSIDE OXIDASE AND METHOD FOR ITS OBTAINMENT AND USE OF NUCLEOSIDE OXIDASE |
CA000383582A CA1173767A (en) | 1980-08-12 | 1981-08-11 | Nucleoside oxidase, its production and use |
NLAANVRAGE8103787,A NL187273C (en) | 1980-08-12 | 1981-08-12 | NUCLEOSIDE OXYDASE, METHOD FOR PREPARING THE SAME, METHOD FOR PREPARING NUCLEOSIDE 5'-CARBONIC ACID, METHOD FOR DETERMINING NUCLEOSIDES IN A LIQUID SAMPLE, AND A REAGENTIACOMPINATION. |
GB8124708A GB2087401B (en) | 1980-08-12 | 1981-08-12 | Nucleoside oxidase its production and use in determining nucleosides |
IT23478/81A IT1168159B (en) | 1980-08-12 | 1981-08-12 | NUCLEOSIDE OXIDASE, ITS PRODUCTION AND USE |
US06/292,154 US4385112A (en) | 1980-08-12 | 1981-08-12 | Nucleoside oxidase and process for making same, and process and kit for using same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14406480A JPS5768794A (en) | 1980-10-14 | 1980-10-14 | Preparation of nucleoside-5'-carboxylic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5768794A true JPS5768794A (en) | 1982-04-27 |
Family
ID=15353457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14406480A Pending JPS5768794A (en) | 1980-08-12 | 1980-10-14 | Preparation of nucleoside-5'-carboxylic acids |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5768794A (en) |
-
1980
- 1980-10-14 JP JP14406480A patent/JPS5768794A/en active Pending
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