JPS5762299A - Preparation of 17alpha-cyanosteroid - Google Patents

Preparation of 17alpha-cyanosteroid

Info

Publication number
JPS5762299A
JPS5762299A JP13715480A JP13715480A JPS5762299A JP S5762299 A JPS5762299 A JP S5762299A JP 13715480 A JP13715480 A JP 13715480A JP 13715480 A JP13715480 A JP 13715480A JP S5762299 A JPS5762299 A JP S5762299A
Authority
JP
Japan
Prior art keywords
dione
cyano
alcoholic solvent
derivative
cyanosteroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13715480A
Other languages
Japanese (ja)
Inventor
Kazumasa Nitta
Shinya Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP13715480A priority Critical patent/JPS5762299A/en
Publication of JPS5762299A publication Critical patent/JPS5762299A/en
Pending legal-status Critical Current

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  • Steroid Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an intermediate for a luteohormone (derivative) in high selectivity and high yield, by isomerizing a 17-ketosteriod in the presence of a specific cyano compound in a lower alcoholic solvent.
CONSTITUTION: Androst-4-ene-3,17--dione, androsta-4,9(11)-diene-3,17-dione or an acetal derivative at the 3-position thereof is siomerized in the presence of a cyano compound expressed by the formula MCN (M is alkali metal or a protonated amine), e.g. a basic cyanide such as sodium cyanide or triethylammonium hydrocyanide, in a molar amount of 1.1W3 times that of the steriod in a lower alcoholic solvent, preferably 1W3C alkyl, at 0W30°C for 2W7hr to give the aimed 17β-cyano-17α- hydroxysteriod.
COPYRIGHT: (C)1982,JPO&Japio
JP13715480A 1980-10-01 1980-10-01 Preparation of 17alpha-cyanosteroid Pending JPS5762299A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13715480A JPS5762299A (en) 1980-10-01 1980-10-01 Preparation of 17alpha-cyanosteroid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13715480A JPS5762299A (en) 1980-10-01 1980-10-01 Preparation of 17alpha-cyanosteroid

Publications (1)

Publication Number Publication Date
JPS5762299A true JPS5762299A (en) 1982-04-15

Family

ID=15192078

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13715480A Pending JPS5762299A (en) 1980-10-01 1980-10-01 Preparation of 17alpha-cyanosteroid

Country Status (1)

Country Link
JP (1) JPS5762299A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977255A (en) * 1986-11-05 1990-12-11 The Upjohn Company Steroidal 17α-silyl ethers and process to corticoids and progesterones
CN107286216A (en) * 2016-03-31 2017-10-24 天津金耀集团有限公司 Preparation method with multiple alkene steroidal compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977255A (en) * 1986-11-05 1990-12-11 The Upjohn Company Steroidal 17α-silyl ethers and process to corticoids and progesterones
CN107286216A (en) * 2016-03-31 2017-10-24 天津金耀集团有限公司 Preparation method with multiple alkene steroidal compounds

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