JPS5759858A - Substituted thiobiuret derivative - Google Patents

Substituted thiobiuret derivative

Info

Publication number
JPS5759858A
JPS5759858A JP13702480A JP13702480A JPS5759858A JP S5759858 A JPS5759858 A JP S5759858A JP 13702480 A JP13702480 A JP 13702480A JP 13702480 A JP13702480 A JP 13702480A JP S5759858 A JPS5759858 A JP S5759858A
Authority
JP
Japan
Prior art keywords
formula
thiobiuret
substituted
phenyl
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13702480A
Other languages
Japanese (ja)
Other versions
JPS6147834B2 (en
Inventor
Akira Kajitani
Tomio Yamazaki
Shozo Yamada
Takatsugu Honna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TAIHOU YAKUHIN KOGYO KK
Taiho Pharmaceutical Co Ltd
Original Assignee
TAIHOU YAKUHIN KOGYO KK
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TAIHOU YAKUHIN KOGYO KK, Taiho Pharmaceutical Co Ltd filed Critical TAIHOU YAKUHIN KOGYO KK
Priority to JP13702480A priority Critical patent/JPS5759858A/en
Publication of JPS5759858A publication Critical patent/JPS5759858A/en
Publication of JPS6147834B2 publication Critical patent/JPS6147834B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of formula 1 (R1 and R3 are lower alkyl; R2 is H or lower alkyl; R4 is phenyl or phenyl substituted by halogen, etc.; X and Y are different O or S).
EXAMPLE: 1,5-Dimethyl-1-phenyl-2-thiobiuret.
USE: An anti-inflammatory agent, analgesic agent, antiallergic and diuretic agents.
PROCESS: An isocyanate or isothiocyanate of formula 2 is reacted with urea or thiourea of formula 3 to give the compound of formula 1. The reaction is preferably carried out in the presence of a basic or acidic catalyst in a solvent, e.g. ether, at -20°CW the refluxing temperatuer of the solvent.
COPYRIGHT: (C)1982,JPO&Japio
JP13702480A 1980-09-30 1980-09-30 Substituted thiobiuret derivative Granted JPS5759858A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13702480A JPS5759858A (en) 1980-09-30 1980-09-30 Substituted thiobiuret derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13702480A JPS5759858A (en) 1980-09-30 1980-09-30 Substituted thiobiuret derivative

Publications (2)

Publication Number Publication Date
JPS5759858A true JPS5759858A (en) 1982-04-10
JPS6147834B2 JPS6147834B2 (en) 1986-10-21

Family

ID=15189049

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13702480A Granted JPS5759858A (en) 1980-09-30 1980-09-30 Substituted thiobiuret derivative

Country Status (1)

Country Link
JP (1) JPS5759858A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012174A1 (en) * 1992-11-23 1994-06-09 University Technologies International Inc. Diabetes prevention and treatment
KR100887308B1 (en) * 2007-04-16 2009-03-06 숙명여자대학교산학협력단 Design and Synthesis of Urea and Thiourea Derivatives Having Inhibitory Activities of NO Production in Lipopolysaccharide-activated macrophages

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0352441Y2 (en) * 1985-11-12 1991-11-13

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5018419A (en) * 1973-05-10 1975-02-26
JPS53127436A (en) * 1977-04-12 1978-11-07 Kumiai Chem Ind Co Ltd 1-(n,n-dialkycarbamoyl)-3-(substd, phenyl) thio-ureas and insecticides containing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5018419A (en) * 1973-05-10 1975-02-26
JPS53127436A (en) * 1977-04-12 1978-11-07 Kumiai Chem Ind Co Ltd 1-(n,n-dialkycarbamoyl)-3-(substd, phenyl) thio-ureas and insecticides containing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012174A1 (en) * 1992-11-23 1994-06-09 University Technologies International Inc. Diabetes prevention and treatment
KR100887308B1 (en) * 2007-04-16 2009-03-06 숙명여자대학교산학협력단 Design and Synthesis of Urea and Thiourea Derivatives Having Inhibitory Activities of NO Production in Lipopolysaccharide-activated macrophages

Also Published As

Publication number Publication date
JPS6147834B2 (en) 1986-10-21

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