JPS5756497A - Production of crude ursodeoxycholic acid - Google Patents
Production of crude ursodeoxycholic acidInfo
- Publication number
- JPS5756497A JPS5756497A JP13009480A JP13009480A JPS5756497A JP S5756497 A JPS5756497 A JP S5756497A JP 13009480 A JP13009480 A JP 13009480A JP 13009480 A JP13009480 A JP 13009480A JP S5756497 A JPS5756497 A JP S5756497A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- butanol
- production
- ursodeoxycholic acid
- ketocholanic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 title abstract 2
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 title abstract 2
- 229960001661 ursodiol Drugs 0.000 title abstract 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 abstract 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- OHXPGWPVLFPUSM-KLRNGDHRSA-N 3,7,12-trioxo-5beta-cholanic acid Chemical compound C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC(O)=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C OHXPGWPVLFPUSM-KLRNGDHRSA-N 0.000 abstract 1
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 229960002997 dehydrocholic acid Drugs 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 abstract 1
- LAIZPRYFQUWUBN-UHFFFAOYSA-L nickel chloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].[Cl-].[Ni+2] LAIZPRYFQUWUBN-UHFFFAOYSA-L 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13009480A JPS5756497A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13009480A JPS5756497A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5756497A true JPS5756497A (en) | 1982-04-05 |
| JPS6316400B2 JPS6316400B2 (enrdf_load_stackoverflow) | 1988-04-08 |
Family
ID=15025811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13009480A Granted JPS5756497A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5756497A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58201799A (ja) * | 1982-04-02 | 1983-11-24 | ザンボン・エス・ピ−・エ− | ３α，７β−ジヒドロキシ−５β−コラン酸の製造法 |
| JP2020516700A (ja) * | 2017-04-20 | 2020-06-11 | デーウン・バイオ・インコーポレイテッド | 連続フロー反応を利用した胆汁酸誘導体の製造方法 |
-
1980
- 1980-09-20 JP JP13009480A patent/JPS5756497A/ja active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58201799A (ja) * | 1982-04-02 | 1983-11-24 | ザンボン・エス・ピ−・エ− | ３α，７β−ジヒドロキシ−５β−コラン酸の製造法 |
| JP2020516700A (ja) * | 2017-04-20 | 2020-06-11 | デーウン・バイオ・インコーポレイテッド | 連続フロー反応を利用した胆汁酸誘導体の製造方法 |
| US11053275B2 (en) | 2017-04-20 | 2021-07-06 | Daewoong Bio Inc. | Method for bile acid derivative by using continuous flow reaction |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6316400B2 (enrdf_load_stackoverflow) | 1988-04-08 |
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