JPS5756497A - Production of crude ursodeoxycholic acid - Google Patents
Production of crude ursodeoxycholic acidInfo
- Publication number
- JPS5756497A JPS5756497A JP13009480A JP13009480A JPS5756497A JP S5756497 A JPS5756497 A JP S5756497A JP 13009480 A JP13009480 A JP 13009480A JP 13009480 A JP13009480 A JP 13009480A JP S5756497 A JPS5756497 A JP S5756497A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- butanol
- production
- ursodeoxycholic acid
- ketocholanic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: 3d-Hdroxy-7-ketocholanic acid is hydrogenated in t-butanol in the presence of a catalyst using sodium to produce the titled crude product of relatively high purity easily in an industrial scale.
CONSTITUTION: The hydrogenation of 3d-hydroxy-7-ketocholanic acid is conducted in t-butanol in the presence of a catalyst such as Raney nickel, nickel (II) chloride hexahydrate, iron or manganese (IV) oxide using sodium in such as amount as exceeding 10 times the molar quantity of the ketocholanic acid to produce crude ursodeoxycholic acid. The amount of the t-butanol is more than 10 times, preferably about 300 times the volume/the weight of the ketochloanic acid.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13009480A JPS5756497A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13009480A JPS5756497A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5756497A true JPS5756497A (en) | 1982-04-05 |
JPS6316400B2 JPS6316400B2 (en) | 1988-04-08 |
Family
ID=15025811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13009480A Granted JPS5756497A (en) | 1980-09-20 | 1980-09-20 | Production of crude ursodeoxycholic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5756497A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58201799A (en) * | 1982-04-02 | 1983-11-24 | ザンボン・エス・ピ−・エ− | Manufacture of 3 alpha, 7beta-dihydroxy-5 beta-cholanic acid |
JP2020516700A (en) * | 2017-04-20 | 2020-06-11 | デーウン・バイオ・インコーポレイテッド | Method for producing bile acid derivative using continuous flow reaction |
-
1980
- 1980-09-20 JP JP13009480A patent/JPS5756497A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58201799A (en) * | 1982-04-02 | 1983-11-24 | ザンボン・エス・ピ−・エ− | Manufacture of 3 alpha, 7beta-dihydroxy-5 beta-cholanic acid |
JPH0416478B2 (en) * | 1982-04-02 | 1992-03-24 | Zambon Spa | |
JP2020516700A (en) * | 2017-04-20 | 2020-06-11 | デーウン・バイオ・インコーポレイテッド | Method for producing bile acid derivative using continuous flow reaction |
US11053275B2 (en) | 2017-04-20 | 2021-07-06 | Daewoong Bio Inc. | Method for bile acid derivative by using continuous flow reaction |
Also Published As
Publication number | Publication date |
---|---|
JPS6316400B2 (en) | 1988-04-08 |
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