JPS5756464A - Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 - Google Patents

Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2

Info

Publication number
JPS5756464A
JPS5756464A JP55130643A JP13064380A JPS5756464A JP S5756464 A JPS5756464 A JP S5756464A JP 55130643 A JP55130643 A JP 55130643A JP 13064380 A JP13064380 A JP 13064380A JP S5756464 A JPS5756464 A JP S5756464A
Authority
JP
Japan
Prior art keywords
thromboxane
inhibitor
halogen
compound shown
biosyntesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55130643A
Other languages
English (en)
Japanese (ja)
Other versions
JPS622586B2 (en, 2012
Inventor
Tadao Tauchi
Masanori Kawamura
Tadanori Okada
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Ono Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Kissei Yakuhin Kogyo KK
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd, Kissei Yakuhin Kogyo KK, Ono Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Priority to JP55130643A priority Critical patent/JPS5756464A/ja
Priority to GB8128515A priority patent/GB2084150B/en
Priority to DE19813137674 priority patent/DE3137674A1/de
Priority to US06/304,531 priority patent/US4346099A/en
Publication of JPS5756464A publication Critical patent/JPS5756464A/ja
Publication of JPS622586B2 publication Critical patent/JPS622586B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP55130643A 1980-09-22 1980-09-22 Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 Granted JPS5756464A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP55130643A JPS5756464A (en) 1980-09-22 1980-09-22 Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2
GB8128515A GB2084150B (en) 1980-09-22 1981-09-21 Imidazole derivatives
DE19813137674 DE3137674A1 (de) 1980-09-22 1981-09-22 Imidazolderivate und pharmazeutische mittel, welche diese derivate enthalten
US06/304,531 US4346099A (en) 1980-09-22 1981-09-22 Carboxy-imidazole derivatives, compositions and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55130643A JPS5756464A (en) 1980-09-22 1980-09-22 Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2

Publications (2)

Publication Number Publication Date
JPS5756464A true JPS5756464A (en) 1982-04-05
JPS622586B2 JPS622586B2 (en, 2012) 1987-01-20

Family

ID=15039148

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55130643A Granted JPS5756464A (en) 1980-09-22 1980-09-22 Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2

Country Status (3)

Country Link
JP (1) JPS5756464A (en, 2012)
DE (1) DE3137674A1 (en, 2012)
GB (1) GB2084150B (en, 2012)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034160A (ja) * 1983-08-05 1985-02-21 Nippon Saitetsuku Kk 保存食品の製法
WO1995015951A1 (fr) * 1993-12-10 1995-06-15 Kyorin Pharmaceutical Co. Ltd. Nouveau derive de l'imidazole et sa methode d'obtention

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54109973A (en) * 1978-02-17 1979-08-29 Kissei Pharmaceut Co Ltd Novel imidazole derivative
JPS54109974A (en) * 1978-02-18 1979-08-29 Kissei Pharmaceut Co Ltd Novel imidazolecarboxylic ester derivative
JPS54112863A (en) * 1978-02-20 1979-09-04 Kissei Pharmaceut Co Ltd N-(omega-carboxyalkyl)imidazole
JPS54163573A (en) * 1978-06-09 1979-12-26 Ono Pharmaceutical Co Imidazole derivative and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2016452B (en) * 1978-02-18 1982-07-21 Kissei Pharmaceutical Imidazole compounds
IT1162310B (it) * 1978-05-02 1987-03-25 Ono Pharmaceutical Co Derivati di imidazolo e procedimento per produrli
JPS55313A (en) * 1978-06-13 1980-01-05 Kissei Pharmaceut Co Ltd Imidazole derivative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54109973A (en) * 1978-02-17 1979-08-29 Kissei Pharmaceut Co Ltd Novel imidazole derivative
JPS54109974A (en) * 1978-02-18 1979-08-29 Kissei Pharmaceut Co Ltd Novel imidazolecarboxylic ester derivative
JPS54112863A (en) * 1978-02-20 1979-09-04 Kissei Pharmaceut Co Ltd N-(omega-carboxyalkyl)imidazole
JPS54163573A (en) * 1978-06-09 1979-12-26 Ono Pharmaceutical Co Imidazole derivative and method

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034160A (ja) * 1983-08-05 1985-02-21 Nippon Saitetsuku Kk 保存食品の製法
WO1995015951A1 (fr) * 1993-12-10 1995-06-15 Kyorin Pharmaceutical Co. Ltd. Nouveau derive de l'imidazole et sa methode d'obtention
US6103747A (en) * 1993-12-10 2000-08-15 Kyorin Pharmaceutical Co., Ltd. Imidazole derivatives and process for preparing the same

Also Published As

Publication number Publication date
GB2084150B (en) 1984-07-04
DE3137674A1 (de) 1982-05-19
DE3137674C2 (en, 2012) 1989-12-28
GB2084150A (en) 1982-04-07
JPS622586B2 (en, 2012) 1987-01-20

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