JPS5748998A - Novel condurango glycoside, its preparation and antitumor agent containing the same - Google Patents
Novel condurango glycoside, its preparation and antitumor agent containing the sameInfo
- Publication number
- JPS5748998A JPS5748998A JP12517580A JP12517580A JPS5748998A JP S5748998 A JPS5748998 A JP S5748998A JP 12517580 A JP12517580 A JP 12517580A JP 12517580 A JP12517580 A JP 12517580A JP S5748998 A JPS5748998 A JP S5748998A
- Authority
- JP
- Japan
- Prior art keywords
- condurango
- formula
- glycoside
- condurango glycoside
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930192357 condurangoglycoside Natural products 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000002955 isolation Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- BQPYEFAVIPEQIK-CKXSKKTQSA-N Spinasaponin A Natural products O=C(O)[C@H]1[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@@H](O)[C@@H](O[C@@H]2C(C)(C)[C@H]3[C@@](C)([C@@H]4[C@](C)([C@@]5(C)C([C@H]6[C@@](C(=O)O)(CC5)CCC(C)(C)C6)=CC4)CC3)CC2)O1 BQPYEFAVIPEQIK-CKXSKKTQSA-N 0.000 abstract 1
- KNZSXKKCTOYLSV-VHHWNNOGSA-N ac1l462r Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1CC2=CCC3C4C[C@@H]5O[C@]([C@H]([C@@H]5[C@@]4(C)CCC3[C@@]2(C)CC1)C)(O)CC[C@@H](C)CO[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O KNZSXKKCTOYLSV-VHHWNNOGSA-N 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000004007 reversed phase HPLC Methods 0.000 abstract 1
- KNZSXKKCTOYLSV-UHFFFAOYSA-N trigofoenoside A Natural products O1C(CO)C(O)C(O)C(O)C1OCC(C)CCC(C(C1C2(C)CCC3C4(C)CC5)C)(O)OC1CC2C3CC=C4CC5OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O KNZSXKKCTOYLSV-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12517580A JPS5748998A (en) | 1980-09-09 | 1980-09-09 | Novel condurango glycoside, its preparation and antitumor agent containing the same |
| IT8167295A IT1144136B (it) | 1980-03-05 | 1981-03-03 | Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione |
| BE0/204013A BE887793A (fr) | 1980-03-05 | 1981-03-04 | Nouveaux condurango-glycosides, agents antitumeurs en comprenant et procede pour les preparer |
| AU67800/81A AU6780081A (en) | 1980-03-05 | 1981-03-05 | Novel cundurango glycosides, process for their preparation, antineoplastic agent, and composition containing same |
| DE19813137612 DE3137612A1 (de) | 1980-03-05 | 1981-03-05 | Novel cundurango glycosides,process for their preparation,antineoplastic agent,and composition containing same |
| US06/320,974 US4452786A (en) | 1980-03-05 | 1981-03-05 | Condurango glycoside compounds, processes for their preparation, antitumor agents comprising them and compositions |
| CH7326/81A CH647533A5 (de) | 1980-03-05 | 1981-03-05 | Cundurango-glycosid-verbindungen, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende tumorbekaempfende mittel. |
| PCT/JP1981/000045 WO1981002577A1 (en) | 1980-03-05 | 1981-03-05 | Novel cundurango glycosides,process for their preparation,antineoplastic agent,and composition containing same |
| CA000372389A CA1169852A (en) | 1980-03-05 | 1981-03-05 | Condurango glycoside compounds, antitumor agents comprising them and processes for their preparation |
| EP19810900551 EP0054570A4 (en) | 1980-03-05 | 1981-03-05 | NOVEL CONDURANGO GLYCOSIDES, PROCESS FOR THE PREPARATION THEREOF, ANTINEOPLAST AGENTS, AND COMPOSITION CONTAINING THE SAME. |
| GB8209580A GB2093032B (en) | 1980-03-05 | 1981-03-05 | Novel condurango glycosides process for their preparation antineoplastic agent and composition containing same |
| SE8202140A SE8202140L (sv) | 1980-03-05 | 1982-04-02 | Nya condurango-glykosidforeningar, forfarande for deras framstellning, antitumormedel som omfattar dem och kompositioner der de ingar |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12517580A JPS5748998A (en) | 1980-09-09 | 1980-09-09 | Novel condurango glycoside, its preparation and antitumor agent containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5748998A true JPS5748998A (en) | 1982-03-20 |
| JPS6256160B2 JPS6256160B2 (enrdf_load_stackoverflow) | 1987-11-24 |
Family
ID=14903741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12517580A Granted JPS5748998A (en) | 1980-03-05 | 1980-09-09 | Novel condurango glycoside, its preparation and antitumor agent containing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5748998A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5797600U (enrdf_load_stackoverflow) * | 1980-12-08 | 1982-06-15 |
-
1980
- 1980-09-09 JP JP12517580A patent/JPS5748998A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5797600U (enrdf_load_stackoverflow) * | 1980-12-08 | 1982-06-15 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6256160B2 (enrdf_load_stackoverflow) | 1987-11-24 |
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