JPS5748998A - Novel condurango glycoside, its preparation and antitumor agent containing the same - Google Patents
Novel condurango glycoside, its preparation and antitumor agent containing the sameInfo
- Publication number
- JPS5748998A JPS5748998A JP12517580A JP12517580A JPS5748998A JP S5748998 A JPS5748998 A JP S5748998A JP 12517580 A JP12517580 A JP 12517580A JP 12517580 A JP12517580 A JP 12517580A JP S5748998 A JPS5748998 A JP S5748998A
- Authority
- JP
- Japan
- Prior art keywords
- condurango
- formula
- glycoside
- condurango glycoside
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Condurango glycoside of formula I (R1 is methoxy; R2 is methyl; or R1 is methyl; R2 is hydroxyl).
EXAMPLE: 20-Iso-O-methyl-condurango glycoside D.
USE: Antitumor agnet.
PREPARATION: Condurango glycoside of formula II is subjected to alcoholysis and the resultant reaction mixture is concentrated under reduced pressure to dryness. The residue is subjected to ordinary-phase HPLC, then reversed-phase HPLC to effect isolation and purification to obtain the compound of formula II. Further, the compound of formula II is hydrolyzed and subjected to the same treatment as above to give the compound of formula I (condurango glycoside Do) where R1 is mathyl and R2 is hydroxyl. The condurango glycoside Bo of formual II is obtained by subjecting a fraction from crushed condurango suluble in methanol and chloroform but insoluble n-hexane to HPLC for isolation and purification.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12517580A JPS5748998A (en) | 1980-09-09 | 1980-09-09 | Novel condurango glycoside, its preparation and antitumor agent containing the same |
IT8167295A IT1144136B (en) | 1980-03-05 | 1981-03-03 | GLUCOSIDES OF CONDUCT ANTI-CANCER AGENTS INCLUDING THEM AND PROCEDURE FOR THEIR PREPARATION |
BE0/204013A BE887793A (en) | 1980-03-05 | 1981-03-04 | NOVEL CONDURANGO-GLYCOSIDES, ANTI-TUMOR AGENTS COMPRISING SAME, AND PROCESS FOR PREPARING THE SAME |
GB8209580A GB2093032B (en) | 1980-03-05 | 1981-03-05 | Novel condurango glycosides process for their preparation antineoplastic agent and composition containing same |
DE19813137612 DE3137612A1 (en) | 1980-03-05 | 1981-03-05 | NOVEL CUNDURANGO GLYCOSIDES, PROCESS FOR THEIR PREPARATION, ANTINEOPLASTIC AGENT, AND COMPOSITION CONTAINING SAME |
PCT/JP1981/000045 WO1981002577A1 (en) | 1980-03-05 | 1981-03-05 | Novel cundurango glycosides,process for their preparation,antineoplastic agent,and composition containing same |
CA000372389A CA1169852A (en) | 1980-03-05 | 1981-03-05 | Condurango glycoside compounds, antitumor agents comprising them and processes for their preparation |
CH7326/81A CH647533A5 (en) | 1980-03-05 | 1981-03-05 | CUNDURANGO-GLYCOSIDE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND TUMOR-FIGHTING AGENTS CONTAINING THESE COMPOUNDS. |
US06/320,974 US4452786A (en) | 1980-03-05 | 1981-03-05 | Condurango glycoside compounds, processes for their preparation, antitumor agents comprising them and compositions |
EP19810900551 EP0054570A4 (en) | 1980-03-05 | 1981-03-05 | Novel condurango glycosides, process for their preparation, antineoplastic agent, and composition containing same. |
AU67800/81A AU6780081A (en) | 1980-03-05 | 1981-03-05 | Novel cundurango glycosides, process for their preparation, antineoplastic agent, and composition containing same |
SE8202140A SE8202140L (en) | 1980-03-05 | 1982-04-02 | NEW CONDURANGO-GLYCOSIDE ASSOCIATIONS, PROCEDURES FOR THEIR PREPARATION, ANTITUMORS THAT INCLUDE THEM AND COMPOSITIONS WHICH THEY CONTAIN |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12517580A JPS5748998A (en) | 1980-09-09 | 1980-09-09 | Novel condurango glycoside, its preparation and antitumor agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5748998A true JPS5748998A (en) | 1982-03-20 |
JPS6256160B2 JPS6256160B2 (en) | 1987-11-24 |
Family
ID=14903741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12517580A Granted JPS5748998A (en) | 1980-03-05 | 1980-09-09 | Novel condurango glycoside, its preparation and antitumor agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5748998A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5797600U (en) * | 1980-12-08 | 1982-06-15 |
-
1980
- 1980-09-09 JP JP12517580A patent/JPS5748998A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5797600U (en) * | 1980-12-08 | 1982-06-15 | ||
JPS588314Y2 (en) * | 1980-12-08 | 1983-02-15 | 株式会社 タカラ | toy hammer |
Also Published As
Publication number | Publication date |
---|---|
JPS6256160B2 (en) | 1987-11-24 |
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