JPS5748935A - Preparation of 2-substituted cycloalkanone - Google Patents
Preparation of 2-substituted cycloalkanoneInfo
- Publication number
- JPS5748935A JPS5748935A JP12554980A JP12554980A JPS5748935A JP S5748935 A JPS5748935 A JP S5748935A JP 12554980 A JP12554980 A JP 12554980A JP 12554980 A JP12554980 A JP 12554980A JP S5748935 A JPS5748935 A JP S5748935A
- Authority
- JP
- Japan
- Prior art keywords
- water
- formula
- soluble amine
- enamine
- cycloalkanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled substance by condensing an enamine derived from a cycloalkanone and a water-soluble amine with an aldehyde, heating and hydrolyzing the resulted 2-substituted enamine in the presence of water, and purifying and recycling the water-soluble amine obtained as a by-product.
CONSTITUTION: A cycloalkanone of formula I (n is integer 2W9) is made to react with a water-soluble amine of formula III (R2 is secondary amino residue) using a dehydration catalyst in the presence of a water-insoluble solvent capable of forming an azeotropic mixture with water to obtain the enamine of formula IV, which is condensed with an aldehyde of formula V (R1 is hydrocarbon residue) to afford the 2- substituted enamine of formula VI. The compound is hydrolyzed to the 2-substituted cycloalkanone of formula II and the water-soluble amine of formula III by heating in the presence of water, and the reaction product is separated into the organic phase and the aqueous phase. The water-soluble amine extracted to the aqueous phase is recycled to the first step, and the organic phase is purified to obtain the objective compound of formula II.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12554980A JPS5748935A (en) | 1980-09-10 | 1980-09-10 | Preparation of 2-substituted cycloalkanone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12554980A JPS5748935A (en) | 1980-09-10 | 1980-09-10 | Preparation of 2-substituted cycloalkanone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5748935A true JPS5748935A (en) | 1982-03-20 |
JPS6338013B2 JPS6338013B2 (en) | 1988-07-28 |
Family
ID=14912946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12554980A Granted JPS5748935A (en) | 1980-09-10 | 1980-09-10 | Preparation of 2-substituted cycloalkanone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5748935A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60228444A (en) * | 1984-04-27 | 1985-11-13 | Nippon Zeon Co Ltd | Preparation of substituent group-containing alicyclic enamine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5040540A (en) * | 1973-05-24 | 1975-04-14 |
-
1980
- 1980-09-10 JP JP12554980A patent/JPS5748935A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5040540A (en) * | 1973-05-24 | 1975-04-14 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60228444A (en) * | 1984-04-27 | 1985-11-13 | Nippon Zeon Co Ltd | Preparation of substituent group-containing alicyclic enamine |
JPH0219817B2 (en) * | 1984-04-27 | 1990-05-07 | Nippon Zeon Co |
Also Published As
Publication number | Publication date |
---|---|
JPS6338013B2 (en) | 1988-07-28 |
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