JPS5738774A - Uracil derivative and its preparation - Google Patents

Uracil derivative and its preparation

Info

Publication number
JPS5738774A
JPS5738774A JP11299380A JP11299380A JPS5738774A JP S5738774 A JPS5738774 A JP S5738774A JP 11299380 A JP11299380 A JP 11299380A JP 11299380 A JP11299380 A JP 11299380A JP S5738774 A JPS5738774 A JP S5738774A
Authority
JP
Japan
Prior art keywords
alkyl
formula
halogen
uracil
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11299380A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0140830B2 (cg-RX-API-DMAC10.html
Inventor
Kiyoshige Ochi
Katsuhito Miyamoto
Hiroshige Mitsui
Yumiko Tsuruma
Isao Matsunaga
Takashi Matsuno
Shigeru Takanashi
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP11299380A priority Critical patent/JPS5738774A/ja
Priority to US06/291,847 priority patent/US4415573A/en
Priority to CA000383943A priority patent/CA1148546A/en
Priority to EP81106460A priority patent/EP0046307B1/en
Priority to DE8181106460T priority patent/DE3167320D1/de
Priority to AT81106460T priority patent/ATE10368T1/de
Publication of JPS5738774A publication Critical patent/JPS5738774A/ja
Publication of JPH0140830B2 publication Critical patent/JPH0140830B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP11299380A 1980-08-19 1980-08-19 Uracil derivative and its preparation Granted JPS5738774A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP11299380A JPS5738774A (en) 1980-08-19 1980-08-19 Uracil derivative and its preparation
US06/291,847 US4415573A (en) 1980-08-19 1981-08-10 Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same
CA000383943A CA1148546A (en) 1980-08-19 1981-08-14 Uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same
EP81106460A EP0046307B1 (en) 1980-08-19 1981-08-19 Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same
DE8181106460T DE3167320D1 (en) 1980-08-19 1981-08-19 Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same
AT81106460T ATE10368T1 (de) 1980-08-19 1981-08-19 Uracilderivate, verfahren zu ihrer herstellung und eine diese enthaltende pharmazeutische zubereitung.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11299380A JPS5738774A (en) 1980-08-19 1980-08-19 Uracil derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5738774A true JPS5738774A (en) 1982-03-03
JPH0140830B2 JPH0140830B2 (cg-RX-API-DMAC10.html) 1989-08-31

Family

ID=14600731

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11299380A Granted JPS5738774A (en) 1980-08-19 1980-08-19 Uracil derivative and its preparation

Country Status (6)

Country Link
US (1) US4415573A (cg-RX-API-DMAC10.html)
EP (1) EP0046307B1 (cg-RX-API-DMAC10.html)
JP (1) JPS5738774A (cg-RX-API-DMAC10.html)
AT (1) ATE10368T1 (cg-RX-API-DMAC10.html)
CA (1) CA1148546A (cg-RX-API-DMAC10.html)
DE (1) DE3167320D1 (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5839672A (ja) * 1981-09-03 1983-03-08 Chugai Pharmaceut Co Ltd ウラシル誘導体
JPS5980620A (ja) * 1982-09-17 1984-05-10 グラクソ・グル−プ・リミテツド ５−ハロビニル−２′−デオキシウリジン誘導体

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1235864A1 (ru) * 1983-03-11 1986-06-07 Отделение ордена Ленина института химической физики АН СССР Нитроксильные производные 5-фторурацила,обладающие противоопухолевой активностью
JPS61204190A (ja) * 1985-03-06 1986-09-10 Kanto Ishi Pharma Co Ltd グリコシド及びその製造方法
US4719214A (en) * 1985-07-25 1988-01-12 Southern Research Institute Carbocyclic analogues of thymine nucleosides
US4613604A (en) * 1985-07-31 1986-09-23 Brown University Research Foundation Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine
JPS62174060A (ja) * 1985-10-11 1987-07-30 Terumo Corp ５−フルオロウラシル誘導体およびこれを含有する医薬製剤
HU206328B (en) * 1988-03-31 1992-10-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral phqrmaceutical compositions containing them as active components
US6903224B2 (en) 1988-04-11 2005-06-07 Biochem Pharma Inc. Substituted 1,3-oxathiolanes
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US6175008B1 (en) 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US6350753B1 (en) 1988-04-11 2002-02-26 Biochem Pharma Inc. 2-Substituted-4-substituted-1,3-dioxolanes and use thereof
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US7119202B1 (en) 1989-02-08 2006-10-10 Glaxo Wellcome Inc. Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
EP0425669B1 (en) * 1988-07-18 1995-01-25 Yamasa Shoyu Kabushiki Kaisha also trading as Yamasa Corporation 1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient
DE3905725A1 (de) * 1989-02-24 1990-09-06 Boehringer Mannheim Gmbh Seco-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung als antivirale mittel
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
DE69430587T2 (de) * 1994-02-28 2003-01-09 Sunkyong Industries Co. Ltd., Suwon Pyrimidin-acyclonukleosid-derivate
NZ513094A (en) * 1998-12-23 2004-05-28 Shire Biochem Inc Antiviral nucleoside analogues

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51113882A (en) * 1975-04-01 1976-10-07 Mitsui Pharmaceut Inc Method for preparing 1-(alpha -alkoxyalkyl)-uracil derivatives
JPS52128384A (en) * 1976-04-20 1977-10-27 Taiho Pharmaceutical Co Ltd 55fluorouracile derivative and its production
JPS5318585A (en) * 1976-07-30 1978-02-20 Taiho Pharmaceutical Co Ltd Production of 55fluoruracil derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947444A (en) * 1973-06-21 1976-03-30 Solomon Aronovich Giller Process for producing N1 -(Dihydroxyalkyl)-5-substituted uracils
JPS52153977A (en) * 1976-06-11 1977-12-21 Daikin Ind Ltd Synthesis of 5-fluorouracil and its derivatives
JPS5331676A (en) * 1976-09-06 1978-03-25 Mitsui Toatsu Chem Inc Uracil derivatives and their preparation
CH633280A5 (de) * 1978-03-09 1982-11-30 Elkawi Ag 5-fluoruracil-derivate und diese verbindungen enthaltende arzneimittel.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51113882A (en) * 1975-04-01 1976-10-07 Mitsui Pharmaceut Inc Method for preparing 1-(alpha -alkoxyalkyl)-uracil derivatives
JPS52128384A (en) * 1976-04-20 1977-10-27 Taiho Pharmaceutical Co Ltd 55fluorouracile derivative and its production
JPS5318585A (en) * 1976-07-30 1978-02-20 Taiho Pharmaceutical Co Ltd Production of 55fluoruracil derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5839672A (ja) * 1981-09-03 1983-03-08 Chugai Pharmaceut Co Ltd ウラシル誘導体
JPS5980620A (ja) * 1982-09-17 1984-05-10 グラクソ・グル−プ・リミテツド ５−ハロビニル−２′−デオキシウリジン誘導体

Also Published As

Publication number Publication date
DE3167320D1 (en) 1985-01-03
JPH0140830B2 (cg-RX-API-DMAC10.html) 1989-08-31
EP0046307B1 (en) 1984-11-21
EP0046307A1 (en) 1982-02-24
ATE10368T1 (de) 1984-12-15
CA1148546A (en) 1983-06-21
US4415573A (en) 1983-11-15

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