JPS5728073A - Inhibitor for aldose reducing enzyme - Google Patents
Inhibitor for aldose reducing enzymeInfo
- Publication number
- JPS5728073A JPS5728073A JP10471780A JP10471780A JPS5728073A JP S5728073 A JPS5728073 A JP S5728073A JP 10471780 A JP10471780 A JP 10471780A JP 10471780 A JP10471780 A JP 10471780A JP S5728073 A JPS5728073 A JP S5728073A
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- compound
- reducing enzyme
- sorbitol
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 150000001323 aldoses Chemical class 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000000600 sorbitol Substances 0.000 abstract 2
- 206010007749 Cataract diabetic Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010029333 Neurosis Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000000695 crystalline len Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000007025 diabetic cataract Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 208000015238 neurotic disease Diseases 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 150000003548 thiazolidines Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10471780A JPS5728073A (en) | 1980-07-29 | 1980-07-29 | Inhibitor for aldose reducing enzyme |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10471780A JPS5728073A (en) | 1980-07-29 | 1980-07-29 | Inhibitor for aldose reducing enzyme |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5728073A true JPS5728073A (en) | 1982-02-15 |
| JPH0135831B2 JPH0135831B2 (enrdf_load_stackoverflow) | 1989-07-27 |
Family
ID=14388230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10471780A Granted JPS5728073A (en) | 1980-07-29 | 1980-07-29 | Inhibitor for aldose reducing enzyme |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5728073A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59137474A (ja) * | 1983-01-17 | 1984-08-07 | ファイザ−・インコ−ポレ−テッド | アルド−ス還元酵素を阻害する、５−（２−アルコキシフエニル）チアゾリジンジオン類 |
| US4602026A (en) * | 1984-08-03 | 1986-07-22 | Senju Pharmaceutical Co., Ltd. | Ophthalmic topical agent for remedy of diseases of iris and ciliary body |
| US4617312A (en) * | 1983-01-17 | 1986-10-14 | Pfizer Inc. | Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones |
| WO1992014730A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production thereof |
| WO1992014719A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production of the same |
| WO1997022600A1 (fr) * | 1995-12-18 | 1997-06-26 | Kyorin Pharmaceutical Co., Ltd. | Derives de la dioxothiazolidylbenzamide substitues en n et leur procede d'obtention |
| JPH10167986A (ja) * | 1995-06-20 | 1998-06-23 | Takeda Chem Ind Ltd | 医 薬 |
-
1980
- 1980-07-29 JP JP10471780A patent/JPS5728073A/ja active Granted
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59137474A (ja) * | 1983-01-17 | 1984-08-07 | ファイザ−・インコ−ポレ−テッド | アルド−ス還元酵素を阻害する、５−（２−アルコキシフエニル）チアゾリジンジオン類 |
| US4617312A (en) * | 1983-01-17 | 1986-10-14 | Pfizer Inc. | Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones |
| US4602026A (en) * | 1984-08-03 | 1986-07-22 | Senju Pharmaceutical Co., Ltd. | Ophthalmic topical agent for remedy of diseases of iris and ciliary body |
| WO1992014730A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production thereof |
| WO1992014719A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production of the same |
| US5308856A (en) * | 1991-02-25 | 1994-05-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives, salts and preparation processes thereof |
| US5342850A (en) * | 1991-02-25 | 1994-08-30 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives, their salts and their preparation processes |
| JPH10167986A (ja) * | 1995-06-20 | 1998-06-23 | Takeda Chem Ind Ltd | 医 薬 |
| US7538125B2 (en) | 1995-06-20 | 2009-05-26 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
| US7842706B2 (en) | 1995-06-20 | 2010-11-30 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
| WO1997022600A1 (fr) * | 1995-12-18 | 1997-06-26 | Kyorin Pharmaceutical Co., Ltd. | Derives de la dioxothiazolidylbenzamide substitues en n et leur procede d'obtention |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0135831B2 (enrdf_load_stackoverflow) | 1989-07-27 |
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