JPS5726688A - Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative - Google Patents

Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative

Info

Publication number
JPS5726688A
JPS5726688A JP10180580A JP10180580A JPS5726688A JP S5726688 A JPS5726688 A JP S5726688A JP 10180580 A JP10180580 A JP 10180580A JP 10180580 A JP10180580 A JP 10180580A JP S5726688 A JPS5726688 A JP S5726688A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
derivative
shown
acid
carboxylic acid
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10180580A
Other versions
JPS6247187B2 (en )
Inventor
Kimihiko Abe
Isao Hayakawa
Yoshiaki Tanaka
Toshiyuki Yoshioka
Original Assignee
Dai Ichi Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Abstract

NEW MATERIAL:A 5,8-dihyrofuro or 2,3,5,8-tetrahydrofuro[ 3,2-b ]1,8-naphthyridine-7-carboxylic acid derivative (salt) shown by the formula I (R is H or lower alkyl).
EXAMPLE: 5, 8-Dihyro-5-( 2-hydroxyethyl )-8-oxofuro[ 3, 2-b ]1, 8-naph-thyridine- 7-carboxylic acid(salt).
USE: An antibacterial agent, a remedy for microbism, especially for uropathy.
PROCESS: For example, a compound shown by the formula II is formula II is heated with a dialkylformamide dialkyl acetal and a secondary amine to give an enamino compound, which is heated in an alcohol in the presence of an inorganic acid, e.g., hydrobromic acid, etc. to give an acetal derivative shown by the formula III. This derivative is treated with a Lewis acid, e.g., conc. sulfuric acid, etc. to give a furo[3,2-b]1,8-naph-thyridine derivative shown by the formula IV, and, if necessary, hydrolyzed and subjected to catalytic reduction.
COPYRIGHT: (C)1982,JPO&Japio
JP10180580A 1980-07-24 1980-07-24 Expired JPS6247187B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10180580A JPS6247187B2 (en) 1980-07-24 1980-07-24

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10180580A JPS6247187B2 (en) 1980-07-24 1980-07-24

Publications (2)

Publication Number Publication Date
JPS5726688A true true JPS5726688A (en) 1982-02-12
JPS6247187B2 JPS6247187B2 (en) 1987-10-06

Family

ID=14310345

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10180580A Expired JPS6247187B2 (en) 1980-07-24 1980-07-24

Country Status (1)

Country Link
JP (1) JPS6247187B2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446109A (en) * 1993-02-23 1995-08-29 Teijin Limited Polyamide/aliphatic polyester block copolymer, process for the production thereof, and blend containing the same
US5854376A (en) * 1995-03-09 1998-12-29 Sekisui Kaseihin Kogyo Kabushiki Kaisha Aliphatic ester-amide copolymer resins
WO2008046135A1 (en) * 2006-10-16 2008-04-24 Bionomics Limited Novel anxiolytic compounds
US9023848B2 (en) 2011-03-02 2015-05-05 Bionomics Limited Small-molecules as therapeutics
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446109A (en) * 1993-02-23 1995-08-29 Teijin Limited Polyamide/aliphatic polyester block copolymer, process for the production thereof, and blend containing the same
US5854376A (en) * 1995-03-09 1998-12-29 Sekisui Kaseihin Kogyo Kabushiki Kaisha Aliphatic ester-amide copolymer resins
WO2008046135A1 (en) * 2006-10-16 2008-04-24 Bionomics Limited Novel anxiolytic compounds
US8293737B2 (en) 2006-10-16 2012-10-23 Bionomics Limited Anxiolytic compounds
US8551990B2 (en) 2006-10-16 2013-10-08 Bionomics Limited Anxiolytic compounds
US8614212B2 (en) 2006-10-16 2013-12-24 Bionomics Limited Anxiolytic compounds
US8906912B2 (en) 2006-10-16 2014-12-09 Bionomics Limited Anxiolytic compounds
US9573945B2 (en) 2006-10-16 2017-02-21 Bionomics Limited Anxiolytic compounds
JP2017105818A (en) * 2006-10-16 2017-06-15 バイオノミクス リミテッド Novel anti-anxiety drug compounds
US9975892B2 (en) 2006-10-16 2018-05-22 Bionomics Limited Anxiolytic compounds
US9023848B2 (en) 2011-03-02 2015-05-05 Bionomics Limited Small-molecules as therapeutics
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines

Also Published As

Publication number Publication date Type
JPS6247187B2 (en) 1987-10-06 grant

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