JPS5726688A - Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative - Google Patents
Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivativeInfo
- Publication number
- JPS5726688A JPS5726688A JP10180580A JP10180580A JPS5726688A JP S5726688 A JPS5726688 A JP S5726688A JP 10180580 A JP10180580 A JP 10180580A JP 10180580 A JP10180580 A JP 10180580A JP S5726688 A JPS5726688 A JP S5726688A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- carboxylic acid
- acid
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 5,8-dihyrofuro or 2,3,5,8-tetrahydrofuro[ 3,2-b ]1,8-naphthyridine-7-carboxylic acid derivative (salt) shown by the formula I (R is H or lower alkyl).
EXAMPLE: 5, 8-Dihyro-5-( 2-hydroxyethyl )-8-oxofuro[ 3, 2-b ]1, 8-naph-thyridine- 7-carboxylic acid(salt).
USE: An antibacterial agent, a remedy for microbism, especially for uropathy.
PROCESS: For example, a compound shown by the formula II is formula II is heated with a dialkylformamide dialkyl acetal and a secondary amine to give an enamino compound, which is heated in an alcohol in the presence of an inorganic acid, e.g., hydrobromic acid, etc. to give an acetal derivative shown by the formula III. This derivative is treated with a Lewis acid, e.g., conc. sulfuric acid, etc. to give a furo[3,2-b]1,8-naph-thyridine derivative shown by the formula IV, and, if necessary, hydrolyzed and subjected to catalytic reduction.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10180580A JPS5726688A (en) | 1980-07-24 | 1980-07-24 | Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10180580A JPS5726688A (en) | 1980-07-24 | 1980-07-24 | Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5726688A true JPS5726688A (en) | 1982-02-12 |
JPS6247187B2 JPS6247187B2 (en) | 1987-10-06 |
Family
ID=14310345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10180580A Granted JPS5726688A (en) | 1980-07-24 | 1980-07-24 | Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5726688A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5446109A (en) * | 1993-02-23 | 1995-08-29 | Teijin Limited | Polyamide/aliphatic polyester block copolymer, process for the production thereof, and blend containing the same |
US5854376A (en) * | 1995-03-09 | 1998-12-29 | Sekisui Kaseihin Kogyo Kabushiki Kaisha | Aliphatic ester-amide copolymer resins |
WO2008046135A1 (en) * | 2006-10-16 | 2008-04-24 | Bionomics Limited | Novel anxiolytic compounds |
US9023848B2 (en) | 2011-03-02 | 2015-05-05 | Bionomics Limited | Small-molecules as therapeutics |
US9133188B2 (en) | 2011-05-12 | 2015-09-15 | Bionomics Limited | Methods for preparing naphthyridines |
US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
-
1980
- 1980-07-24 JP JP10180580A patent/JPS5726688A/en active Granted
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5446109A (en) * | 1993-02-23 | 1995-08-29 | Teijin Limited | Polyamide/aliphatic polyester block copolymer, process for the production thereof, and blend containing the same |
US5854376A (en) * | 1995-03-09 | 1998-12-29 | Sekisui Kaseihin Kogyo Kabushiki Kaisha | Aliphatic ester-amide copolymer resins |
US8906912B2 (en) | 2006-10-16 | 2014-12-09 | Bionomics Limited | Anxiolytic compounds |
US8293737B2 (en) | 2006-10-16 | 2012-10-23 | Bionomics Limited | Anxiolytic compounds |
US8551990B2 (en) | 2006-10-16 | 2013-10-08 | Bionomics Limited | Anxiolytic compounds |
US8614212B2 (en) | 2006-10-16 | 2013-12-24 | Bionomics Limited | Anxiolytic compounds |
WO2008046135A1 (en) * | 2006-10-16 | 2008-04-24 | Bionomics Limited | Novel anxiolytic compounds |
US9573945B2 (en) | 2006-10-16 | 2017-02-21 | Bionomics Limited | Anxiolytic compounds |
JP2017105818A (en) * | 2006-10-16 | 2017-06-15 | バイオノミクス リミテッド | Novel anxiolytic compounds |
US9975892B2 (en) | 2006-10-16 | 2018-05-22 | Bionomics Limited | Anxiolytic compounds |
US10233181B2 (en) | 2006-10-16 | 2019-03-19 | Bionomics Limited | Anxiolytic compounds |
US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
US9023848B2 (en) | 2011-03-02 | 2015-05-05 | Bionomics Limited | Small-molecules as therapeutics |
US9133188B2 (en) | 2011-05-12 | 2015-09-15 | Bionomics Limited | Methods for preparing naphthyridines |
Also Published As
Publication number | Publication date |
---|---|
JPS6247187B2 (en) | 1987-10-06 |
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