JPS5726688A - Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative - Google Patents

Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative

Info

Publication number
JPS5726688A
JPS5726688A JP10180580A JP10180580A JPS5726688A JP S5726688 A JPS5726688 A JP S5726688A JP 10180580 A JP10180580 A JP 10180580A JP 10180580 A JP10180580 A JP 10180580A JP S5726688 A JPS5726688 A JP S5726688A
Authority
JP
Japan
Prior art keywords
formula
derivative
carboxylic acid
acid
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10180580A
Other languages
Japanese (ja)
Other versions
JPS6247187B2 (en
Inventor
Isao Hayakawa
Kimihiko Abe
Toshiyuki Yoshioka
Yoshiaki Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP10180580A priority Critical patent/JPS5726688A/en
Publication of JPS5726688A publication Critical patent/JPS5726688A/en
Publication of JPS6247187B2 publication Critical patent/JPS6247187B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 5,8-dihyrofuro or 2,3,5,8-tetrahydrofuro[ 3,2-b ]1,8-naphthyridine-7-carboxylic acid derivative (salt) shown by the formula I (R is H or lower alkyl).
EXAMPLE: 5, 8-Dihyro-5-( 2-hydroxyethyl )-8-oxofuro[ 3, 2-b ]1, 8-naph-thyridine- 7-carboxylic acid(salt).
USE: An antibacterial agent, a remedy for microbism, especially for uropathy.
PROCESS: For example, a compound shown by the formula II is formula II is heated with a dialkylformamide dialkyl acetal and a secondary amine to give an enamino compound, which is heated in an alcohol in the presence of an inorganic acid, e.g., hydrobromic acid, etc. to give an acetal derivative shown by the formula III. This derivative is treated with a Lewis acid, e.g., conc. sulfuric acid, etc. to give a furo[3,2-b]1,8-naph-thyridine derivative shown by the formula IV, and, if necessary, hydrolyzed and subjected to catalytic reduction.
COPYRIGHT: (C)1982,JPO&Japio
JP10180580A 1980-07-24 1980-07-24 Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative Granted JPS5726688A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10180580A JPS5726688A (en) 1980-07-24 1980-07-24 Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10180580A JPS5726688A (en) 1980-07-24 1980-07-24 Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative

Publications (2)

Publication Number Publication Date
JPS5726688A true JPS5726688A (en) 1982-02-12
JPS6247187B2 JPS6247187B2 (en) 1987-10-06

Family

ID=14310345

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10180580A Granted JPS5726688A (en) 1980-07-24 1980-07-24 Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative

Country Status (1)

Country Link
JP (1) JPS5726688A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446109A (en) * 1993-02-23 1995-08-29 Teijin Limited Polyamide/aliphatic polyester block copolymer, process for the production thereof, and blend containing the same
US5854376A (en) * 1995-03-09 1998-12-29 Sekisui Kaseihin Kogyo Kabushiki Kaisha Aliphatic ester-amide copolymer resins
WO2008046135A1 (en) * 2006-10-16 2008-04-24 Bionomics Limited Novel anxiolytic compounds
US9023848B2 (en) 2011-03-02 2015-05-05 Bionomics Limited Small-molecules as therapeutics
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446109A (en) * 1993-02-23 1995-08-29 Teijin Limited Polyamide/aliphatic polyester block copolymer, process for the production thereof, and blend containing the same
US5854376A (en) * 1995-03-09 1998-12-29 Sekisui Kaseihin Kogyo Kabushiki Kaisha Aliphatic ester-amide copolymer resins
US8906912B2 (en) 2006-10-16 2014-12-09 Bionomics Limited Anxiolytic compounds
US8293737B2 (en) 2006-10-16 2012-10-23 Bionomics Limited Anxiolytic compounds
US8551990B2 (en) 2006-10-16 2013-10-08 Bionomics Limited Anxiolytic compounds
US8614212B2 (en) 2006-10-16 2013-12-24 Bionomics Limited Anxiolytic compounds
WO2008046135A1 (en) * 2006-10-16 2008-04-24 Bionomics Limited Novel anxiolytic compounds
US9573945B2 (en) 2006-10-16 2017-02-21 Bionomics Limited Anxiolytic compounds
JP2017105818A (en) * 2006-10-16 2017-06-15 バイオノミクス リミテッド Novel anxiolytic compounds
US9975892B2 (en) 2006-10-16 2018-05-22 Bionomics Limited Anxiolytic compounds
US10233181B2 (en) 2006-10-16 2019-03-19 Bionomics Limited Anxiolytic compounds
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
US9023848B2 (en) 2011-03-02 2015-05-05 Bionomics Limited Small-molecules as therapeutics
US9133188B2 (en) 2011-05-12 2015-09-15 Bionomics Limited Methods for preparing naphthyridines

Also Published As

Publication number Publication date
JPS6247187B2 (en) 1987-10-06

Similar Documents

Publication Publication Date Title
JPS5726688A (en) Furo 3,2-b 1,8-naphthyridine-7-carboxylic acid derivative
JPS57176988A (en) Penam-3-carboxylic acid derivative and its preparation
JPS5777689A (en) Novel cephen compound, or its salt, its preparation, and preventive it as active ingredient
DE3571026D1 (en) Process for the obtention of water-free or substantially water-free formic acid by hydraulysis of methyl formiate
JPS5781486A (en) Benzo(ij)quinolidine-2-carboxylic acid derivative
JPS56140943A (en) Preparation of organic compound
JPS5643288A (en) Cephalosporin derivative and its preparation
JPS5583749A (en) Quinolone derivative
JPS5572177A (en) 4,1-benzoxazepine or 4,1-benzothiazepine
JPS57109790A (en) Furo(3,2-b)1,8-naphthyridine-7-carboxylic acid derivative
ES532698A0 (en) A PROCEDURE FOR PREPARING 1, 2, 3-TRIAZINO- (4 ', 5': 4; 5) TIENO (2, 3-B) -QUINOLIN-4 (3H) -ONAS.
JPS5616489A (en) Imidazolecarboxylic acid derivative
JPS56118083A (en) Furo(3,2-b)(1,8)naphthyridine derivative
JPS57209296A (en) Tylosin derivative
JPS57145898A (en) Novel n6, n6-dimethyladenosine derivative
JPS5772981A (en) 1,8-naphthyridine derivative and its salt
JPS574974A (en) Carbostyril derivative
JPS5665840A (en) Stabilizing method of ketone
JPS57118560A (en) Preparation of 1-sulfo-2-oxoazetidine and its intermediate
JPS56150082A (en) Dibenzo b,e oxepin derivative
JPS57197280A (en) Preparation of 2-thioxopenam derivative
JPS56125386A (en) Pyrido (2,3-d)pyrimidine derivative and its preparation
JPS56158786A (en) Novel camptothecin derivative and its preparation
JPS5721400A (en) Novel fortimicin derivative
JPS5640688A (en) Preparation of penicillanic acid derivative