JPS572292A - Production of penem-3-carboxylic derivative - Google Patents

Production of penem-3-carboxylic derivative

Info

Publication number
JPS572292A
JPS572292A JP7612980A JP7612980A JPS572292A JP S572292 A JPS572292 A JP S572292A JP 7612980 A JP7612980 A JP 7612980A JP 7612980 A JP7612980 A JP 7612980A JP S572292 A JPS572292 A JP S572292A
Authority
JP
Japan
Prior art keywords
compound
formula
carboxylic derivative
reaction
penem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7612980A
Other languages
Japanese (ja)
Other versions
JPH0316356B2 (en
Inventor
Tetsuo Miyadera
Masao Sugimura
Teruo Tanaka
Toshihiko Hashimoto
Kimio Iino
Shinichi Sugawara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP7612980A priority Critical patent/JPS572292A/en
Priority to FR8111192A priority patent/FR2483925A1/en
Priority to ES502829A priority patent/ES8207545A1/en
Priority to DE19813122524 priority patent/DE3122524A1/en
Priority to IT22176/81A priority patent/IT1168089B/en
Publication of JPS572292A publication Critical patent/JPS572292A/en
Publication of JPH0316356B2 publication Critical patent/JPH0316356B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: A 2-thioxopenam-3-carboxylic derivative is made to react with an alkylating reagent or hydroxy compound and an azo compound to produce the titled compound used as an antibacterial or synthetic intermediate thereof.
CONSTITUTION: The reaction between a compound of formula 2 (R7 is H, lower alkyl, lower alkoxy; R9 is carboxyl-protecting group) and another compound of formula 4 (R2 is H, lower alkyl; R8 is amino-protecting group; A is lower alkylene with a branched chain; X is halogen) affords a compound of formula 3. Or the reaction between the compound of formula 2, a compound of formula 5 and the third compound of R10OOCN=NCOOR10 (R10 is alkyl) is conducted in the presence of triphenylphosphine to give the compound of formula 3. When necessary, the protecting groups are removed or the substituted groups are exchanged to produce the compound of formula 1 (R1 is R7, lower hydroxyalkyl; R3 is H, R8; R4 is H, R9) and its salt.
COPYRIGHT: (C)1982,JPO&Japio
JP7612980A 1980-06-06 1980-06-06 Production of penem-3-carboxylic derivative Granted JPS572292A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP7612980A JPS572292A (en) 1980-06-06 1980-06-06 Production of penem-3-carboxylic derivative
FR8111192A FR2483925A1 (en) 1980-06-06 1981-06-05 PROCESS FOR PREPARING DERIVATIVES OF PENEME-3-CARBOXYLIC ACID
ES502829A ES8207545A1 (en) 1980-06-06 1981-06-05 Production of penem-3-carboxylic derivative
DE19813122524 DE3122524A1 (en) 1980-06-06 1981-06-05 "Process for the preparation of penem-3-carboxylic acid derivatives"
IT22176/81A IT1168089B (en) 1980-06-06 1981-06-08 PROCEDURE FOR THE PREPARATION OF PENEM-3-CARBOXYLIC ACID DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7612980A JPS572292A (en) 1980-06-06 1980-06-06 Production of penem-3-carboxylic derivative

Publications (2)

Publication Number Publication Date
JPS572292A true JPS572292A (en) 1982-01-07
JPH0316356B2 JPH0316356B2 (en) 1991-03-05

Family

ID=13596320

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7612980A Granted JPS572292A (en) 1980-06-06 1980-06-06 Production of penem-3-carboxylic derivative

Country Status (5)

Country Link
JP (1) JPS572292A (en)
DE (1) DE3122524A1 (en)
ES (1) ES8207545A1 (en)
FR (1) FR2483925A1 (en)
IT (1) IT1168089B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH651037A5 (en) * 1980-06-06 1985-08-30 Sankyo Co PENEM-3-CARBONIC ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
DE3372773D1 (en) * 1982-03-26 1987-09-03 Hoechst Uk Ltd 7-OXO-4-THIA-1-AZABICYCLO (3,2,0) HEPTANE DERIVATIVES
EP0345827A1 (en) * 1982-11-29 1989-12-13 Schering Corporation Process for the production of penem compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS642118A (en) * 1987-06-25 1989-01-06 Nec Corp Console input system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS642118A (en) * 1987-06-25 1989-01-06 Nec Corp Console input system

Also Published As

Publication number Publication date
IT8122176A0 (en) 1981-06-08
FR2483925B1 (en) 1983-06-17
ES502829A0 (en) 1982-10-01
JPH0316356B2 (en) 1991-03-05
IT1168089B (en) 1987-05-20
DE3122524A1 (en) 1982-07-22
ES8207545A1 (en) 1982-10-01
FR2483925A1 (en) 1981-12-11

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