JPS57209262A - 3-chloro-4-hydroxy-5-cyanophenylacetic acid and its preparation - Google Patents
3-chloro-4-hydroxy-5-cyanophenylacetic acid and its preparationInfo
- Publication number
- JPS57209262A JPS57209262A JP9554681A JP9554681A JPS57209262A JP S57209262 A JPS57209262 A JP S57209262A JP 9554681 A JP9554681 A JP 9554681A JP 9554681 A JP9554681 A JP 9554681A JP S57209262 A JPS57209262 A JP S57209262A
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- hydroxy
- acid
- equivalents
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A 3-chloro-4-hydroxy-5-cyanophenylacetic acid of the formula (R is H or alkyl).
EXAMPLE: 3-Chloro-4-hydroxy-5-cyanophenylacetic acid.
USE: An intermediate for medicines and organic synthetic intermediate.
PROCESS: 3-Chloro-4-hydroxy-5-aminophenylacetic acid is diazotized and then reacted with a metallic cyanide, e.g. cuprous cyanide, to give the compound of the formula. The diazotation is generally carried out by dissolving the raw material amine in a dilute inorganic acid, and adding sodium nitrite thereto. The necessary theoretical amount of the acid is two equivalents, but usually 2.5W3 equivalents for preventing the formation of a diazoamino compound as a by-product. The sodium nitrite is used in an equivalent amount, and the end point of the reaction is examined by with potassium iodide starch paper. The reaction is usually carried out at 0W15°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9554681A JPS57209262A (en) | 1981-06-19 | 1981-06-19 | 3-chloro-4-hydroxy-5-cyanophenylacetic acid and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9554681A JPS57209262A (en) | 1981-06-19 | 1981-06-19 | 3-chloro-4-hydroxy-5-cyanophenylacetic acid and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57209262A true JPS57209262A (en) | 1982-12-22 |
| JPH0116825B2 JPH0116825B2 (en) | 1989-03-27 |
Family
ID=14140561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9554681A Granted JPS57209262A (en) | 1981-06-19 | 1981-06-19 | 3-chloro-4-hydroxy-5-cyanophenylacetic acid and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57209262A (en) |
-
1981
- 1981-06-19 JP JP9554681A patent/JPS57209262A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0116825B2 (en) | 1989-03-27 |
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