JPS57200379A - Haloprostacyclins and their preparations - Google Patents
Haloprostacyclins and their preparationsInfo
- Publication number
- JPS57200379A JPS57200379A JP56084463A JP8446381A JPS57200379A JP S57200379 A JPS57200379 A JP S57200379A JP 56084463 A JP56084463 A JP 56084463A JP 8446381 A JP8446381 A JP 8446381A JP S57200379 A JPS57200379 A JP S57200379A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- action
- formulai
- lower alkyl
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 abstract 1
- 229960001123 epoprostenol Drugs 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56084463A JPS57200379A (en) | 1981-06-03 | 1981-06-03 | Haloprostacyclins and their preparations |
DE8181110156T DE3176313D1 (en) | 1980-12-09 | 1981-12-04 | Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof |
US06/327,741 US4472428A (en) | 1980-12-09 | 1981-12-04 | Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore |
EP81110156A EP0054795B1 (en) | 1980-12-09 | 1981-12-04 | Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56084463A JPS57200379A (en) | 1981-06-03 | 1981-06-03 | Haloprostacyclins and their preparations |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57200379A true JPS57200379A (en) | 1982-12-08 |
JPH0212227B2 JPH0212227B2 (enrdf_load_stackoverflow) | 1990-03-19 |
Family
ID=13831313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56084463A Granted JPS57200379A (en) | 1980-12-09 | 1981-06-03 | Haloprostacyclins and their preparations |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57200379A (enrdf_load_stackoverflow) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58150583A (ja) * | 1982-03-04 | 1983-09-07 | Teijin Ltd | 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物 |
-
1981
- 1981-06-03 JP JP56084463A patent/JPS57200379A/ja active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58150583A (ja) * | 1982-03-04 | 1983-09-07 | Teijin Ltd | 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物 |
Also Published As
Publication number | Publication date |
---|---|
JPH0212227B2 (enrdf_load_stackoverflow) | 1990-03-19 |
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