JPS57197252A - Preparation of 2-azido substituted unsaturated carboxylic acid derivative - Google Patents
Preparation of 2-azido substituted unsaturated carboxylic acid derivativeInfo
- Publication number
- JPS57197252A JPS57197252A JP8113081A JP8113081A JPS57197252A JP S57197252 A JPS57197252 A JP S57197252A JP 8113081 A JP8113081 A JP 8113081A JP 8113081 A JP8113081 A JP 8113081A JP S57197252 A JPS57197252 A JP S57197252A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formulai
- alkyl
- sodium azide
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound convertible into a constituent amino acid of physiologically active peptides in high yield in short steps, by reacting an easily available 2,3-disubstituted carboxylic ester with sodium azide in an aprotic polar solvent.
CONSTITUTION: A compound of formulaI(R1 is H, alkyl or aryl, R2 is H or alkyl; X is halogen, alkyl or arylsulfonyloxy) is reacted with sodium azide in an aprotic polar solvent, e.g. DMF, DMSO or hexamethylphosphoric triamide, to give the aimed compound of formula II. 2,3-Dichloropropionic acid, 3-bromo-2- chloropropionic acid, etc. may be cited as the compound of formulaI. The amount of the sodium azide to be used is preferably 2W4 equivalents based on the compound of formulaI. The reaction temperature of 40W80°C provides a high yield of the aimed compound.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8113081A JPS57197252A (en) | 1981-05-29 | 1981-05-29 | Preparation of 2-azido substituted unsaturated carboxylic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8113081A JPS57197252A (en) | 1981-05-29 | 1981-05-29 | Preparation of 2-azido substituted unsaturated carboxylic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57197252A true JPS57197252A (en) | 1982-12-03 |
Family
ID=13737808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8113081A Pending JPS57197252A (en) | 1981-05-29 | 1981-05-29 | Preparation of 2-azido substituted unsaturated carboxylic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57197252A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4572747A (en) * | 1984-02-02 | 1986-02-25 | Armco Inc. | Method of producing boron alloy |
-
1981
- 1981-05-29 JP JP8113081A patent/JPS57197252A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4572747A (en) * | 1984-02-02 | 1986-02-25 | Armco Inc. | Method of producing boron alloy |
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