JPS57193428A - 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same - Google Patents
2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the sameInfo
- Publication number
- JPS57193428A JPS57193428A JP7780081A JP7780081A JPS57193428A JP S57193428 A JPS57193428 A JP S57193428A JP 7780081 A JP7780081 A JP 7780081A JP 7780081 A JP7780081 A JP 7780081A JP S57193428 A JPS57193428 A JP S57193428A
- Authority
- JP
- Japan
- Prior art keywords
- leucotriene
- remedy
- preparation
- compound
- diseases caused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound of formulaI[R1 is 1W6C alkyl, formula II (X is H, halogen, lower alkyl and alkoxy, carboxyl, amino, carbomoyl, sulfamoyl, nitrile; n is 0W2]or its pharmaceutically permissible acid adduct.
EXAMPLE: 2-Propionyl-4-tert.-butyl-6-aminophenol.
USE: A remedy for diseases caused by leucotriene: especially it specifically inhibits the activity of 5-lipoxigenase, but not other enzymes in the arachidonic acid cascade. Thus it is used to prevent and treat allergic diseases of trachea, bronchia and lung, allergic shocks and inflammation of various kinds.
PREPARATION: Selective reduction reaction of a compound of formula III is conducted, for example, in benzene in the presence of titanium trichloride to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7780081A JPS57193428A (en) | 1981-05-22 | 1981-05-22 | 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same |
EP82302598A EP0065874A1 (en) | 1981-05-22 | 1982-05-21 | 2-Aminophenol derivatives, methods for their preparation and composition containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7780081A JPS57193428A (en) | 1981-05-22 | 1981-05-22 | 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57193428A true JPS57193428A (en) | 1982-11-27 |
Family
ID=13644072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7780081A Pending JPS57193428A (en) | 1981-05-22 | 1981-05-22 | 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57193428A (en) |
-
1981
- 1981-05-22 JP JP7780081A patent/JPS57193428A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE862404L (en) | Hydroxamic acid derivatives | |
JPS5520800A (en) | Cephem compounds, their salts, their preparation, and preventive or remedy for microbism containing the same as the effective component | |
JPS5759894A (en) | Cephalosporin for oral administration | |
JPS5587771A (en) | 1-phenylisoquinoline derivative | |
JPS567716A (en) | Preventive and remedy for cerebral angiospasm | |
JPS5553282A (en) | Dibenzothiepin derivative and its preparation | |
DE3160595D1 (en) | Polyprenyl carboxylic acid derivatives, process for the preparation of the same, and pharmaceutical compositions | |
JPS57193428A (en) | 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same | |
JPS57118555A (en) | Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component | |
JPS57140754A (en) | Dihydroxybenzoic acid derivative and physiologically active preparation containing the same | |
ES8502076A1 (en) | 3-Beta-(3'-(carboxypropionyloxy))-ursa-9(11),12-dience-28-carboxylic acid and its salts, process for its preparation and medicines containing these compounds. | |
JPS56156273A (en) | Acetic derivative | |
JPS57165382A (en) | Fluoro-pgi2 compound and its preparation | |
JPS5692261A (en) | Novel cyclohexanecarboxylic derivative and its preparation | |
JPS5692260A (en) | Cyclohexanecarboxylic ester and its preparation | |
JPS5519226A (en) | 5-acyloxymethylindazole derivative, its preparation, and preparation including the same | |
JPS57200370A (en) | 1-acyl group substituted-4-hydroxyalkylhomopiperazine derivative | |
JPS5716856A (en) | 4-guanidinomethylcyclohexanecarboxylic acid ester and its preparation | |
JPS57181012A (en) | Drug composed of polyprenyl compound | |
JPS56125338A (en) | Phenylacetic acid derivative | |
JPS5668611A (en) | Novel antiallergic agent | |
JPS57126418A (en) | Antiallergic agent | |
JPS5562017A (en) | Anti-inflammatory agent comprising guanidine derivative | |
JPS54119478A (en) | Carbostyril derivative | |
JPS5618959A (en) | 4-oxoproline derivative, its preparation, and pharmaceutical composition containing the same |