JPS57193428A - 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same - Google Patents

2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same

Info

Publication number
JPS57193428A
JPS57193428A JP7780081A JP7780081A JPS57193428A JP S57193428 A JPS57193428 A JP S57193428A JP 7780081 A JP7780081 A JP 7780081A JP 7780081 A JP7780081 A JP 7780081A JP S57193428 A JPS57193428 A JP S57193428A
Authority
JP
Japan
Prior art keywords
leucotriene
remedy
preparation
compound
diseases caused
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7780081A
Other languages
Japanese (ja)
Inventor
Tsumoru Miyamoto
Tetsuya Mori
Toru Shigeoka
Hiroyuki Ito
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP7780081A priority Critical patent/JPS57193428A/en
Priority to EP82302598A priority patent/EP0065874A1/en
Publication of JPS57193428A publication Critical patent/JPS57193428A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formulaI[R1 is 1W6C alkyl, formula II (X is H, halogen, lower alkyl and alkoxy, carboxyl, amino, carbomoyl, sulfamoyl, nitrile; n is 0W2]or its pharmaceutically permissible acid adduct.
EXAMPLE: 2-Propionyl-4-tert.-butyl-6-aminophenol.
USE: A remedy for diseases caused by leucotriene: especially it specifically inhibits the activity of 5-lipoxigenase, but not other enzymes in the arachidonic acid cascade. Thus it is used to prevent and treat allergic diseases of trachea, bronchia and lung, allergic shocks and inflammation of various kinds.
PREPARATION: Selective reduction reaction of a compound of formula III is conducted, for example, in benzene in the presence of titanium trichloride to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP7780081A 1981-05-22 1981-05-22 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same Pending JPS57193428A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP7780081A JPS57193428A (en) 1981-05-22 1981-05-22 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same
EP82302598A EP0065874A1 (en) 1981-05-22 1982-05-21 2-Aminophenol derivatives, methods for their preparation and composition containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7780081A JPS57193428A (en) 1981-05-22 1981-05-22 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same

Publications (1)

Publication Number Publication Date
JPS57193428A true JPS57193428A (en) 1982-11-27

Family

ID=13644072

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7780081A Pending JPS57193428A (en) 1981-05-22 1981-05-22 2-acyl-6-aminophenol derivative, its preparation, and remedy for diseases caused by leucotriene containing the same

Country Status (1)

Country Link
JP (1) JPS57193428A (en)

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