JPS57175182A - Novel preparation of benzothiazepin derivative - Google Patents

Novel preparation of benzothiazepin derivative

Info

Publication number
JPS57175182A
JPS57175182A JP6185681A JP6185681A JPS57175182A JP S57175182 A JPS57175182 A JP S57175182A JP 6185681 A JP6185681 A JP 6185681A JP 6185681 A JP6185681 A JP 6185681A JP S57175182 A JPS57175182 A JP S57175182A
Authority
JP
Japan
Prior art keywords
benzothiazepin
hydroxy
solvent
derivative
novel preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6185681A
Other languages
Japanese (ja)
Inventor
Sadayuki Maeda
Takashi Uneda
Yasutaka Shinoo
Masahiro Takatani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamari Chemicals Ltd
Original Assignee
Hamari Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamari Chemicals Ltd filed Critical Hamari Chemicals Ltd
Priority to JP6185681A priority Critical patent/JPS57175182A/en
Publication of JPS57175182A publication Critical patent/JPS57175182A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as pharmaceuticals having coronary vessel dilating action and psychotropic action, with simple procedure, in high yield, by acetylating a 3-hydroxy-benzothiazepin derivative, and then alkylating the product.
CONSTITUTION: 2-( 4-Hydroxyphenyl )-3-hydroxy-5-( 2-dimethylaminoethyl )-2, 3-dihydro-1,5-benzothiazepin-4(5H)-one of formulaIis acetylated with acetic anhydride, glacial acetic acid, etc. in the absence of solvent or in a solvent such as pyridine, trialkylamine, etc. to obtain a novel compound of formula II, which is alkylated with dialkyl sulfate in the presence of an alkali (e.g. sodium hydroxide, potassium hydride, etc.) to obtain the objective compound of formula III.
COPYRIGHT: (C)1982,JPO&Japio
JP6185681A 1981-04-22 1981-04-22 Novel preparation of benzothiazepin derivative Pending JPS57175182A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6185681A JPS57175182A (en) 1981-04-22 1981-04-22 Novel preparation of benzothiazepin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6185681A JPS57175182A (en) 1981-04-22 1981-04-22 Novel preparation of benzothiazepin derivative

Publications (1)

Publication Number Publication Date
JPS57175182A true JPS57175182A (en) 1982-10-28

Family

ID=13183158

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6185681A Pending JPS57175182A (en) 1981-04-22 1981-04-22 Novel preparation of benzothiazepin derivative

Country Status (1)

Country Link
JP (1) JPS57175182A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62161776A (en) * 1986-01-07 1987-07-17 Tanabe Seiyaku Co Ltd Production of 1,5-benzothiazepine derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62161776A (en) * 1986-01-07 1987-07-17 Tanabe Seiyaku Co Ltd Production of 1,5-benzothiazepine derivative
JPH0573749B2 (en) * 1986-01-07 1993-10-15 Tanabe Seiyaku Co

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