JPS57159758A - Preparation of beta-lactam - Google Patents
Preparation of beta-lactamInfo
- Publication number
- JPS57159758A JPS57159758A JP56044080A JP4408081A JPS57159758A JP S57159758 A JPS57159758 A JP S57159758A JP 56044080 A JP56044080 A JP 56044080A JP 4408081 A JP4408081 A JP 4408081A JP S57159758 A JPS57159758 A JP S57159758A
- Authority
- JP
- Japan
- Prior art keywords
- phase
- pharmaceuticals
- lactam
- amino acid
- transfer catalyst
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled compound useful as a basic skeleton of an antibiotic substance, industrial and agricultural chemicals, pharmaceuticals, or intermediate of pharmaceuticals, etc., in high yield, by reacting a β-amino with a condensation agent in a binary phase system comprising an organic phase and a water phase, using a phase transfer catalyst.
CONSTITUTION: A β-lactam of formula II (R1WR5 are organic residue which does not participate in the reaction) (e.g. 1-cyclohexyl-4-methyl-2-azetidinone, etc.) is prepared by reacing a β-amino acid of formulaI[e.g. 3-(cyclohexylamino)butanoic acid, etc.]in a binary phase system comprising an organic solvent phase and water phase using a condensation agent such as methanesulfonyl triazole, etc., a phase transfer catalyst such as tetrabutylammonium hydrogen sulfate, and an alkaline substance such as lithium hydroxide. This process can be applied even to an optically active amino acid without causing isomerization.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56044080A JPS57159758A (en) | 1981-03-27 | 1981-03-27 | Preparation of beta-lactam |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56044080A JPS57159758A (en) | 1981-03-27 | 1981-03-27 | Preparation of beta-lactam |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57159758A true JPS57159758A (en) | 1982-10-01 |
JPH0254339B2 JPH0254339B2 (en) | 1990-11-21 |
Family
ID=12681635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56044080A Granted JPS57159758A (en) | 1981-03-27 | 1981-03-27 | Preparation of beta-lactam |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57159758A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002050025A1 (en) * | 2000-12-21 | 2002-06-27 | National Institute Of Advanced Industrial Science And Technology | PROCESS FOR SYNTHESIZING β-LACTAM |
-
1981
- 1981-03-27 JP JP56044080A patent/JPS57159758A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002050025A1 (en) * | 2000-12-21 | 2002-06-27 | National Institute Of Advanced Industrial Science And Technology | PROCESS FOR SYNTHESIZING β-LACTAM |
US7022842B2 (en) | 2000-12-21 | 2006-04-04 | National Institute Of Advanced Industrial Science And Technology | Process for synthesizing beta-lactam |
Also Published As
Publication number | Publication date |
---|---|
JPH0254339B2 (en) | 1990-11-21 |
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