JPS57159738A - 2-halomethylene-arylacetice acid derivative - Google Patents
2-halomethylene-arylacetice acid derivativeInfo
- Publication number
- JPS57159738A JPS57159738A JP4551081A JP4551081A JPS57159738A JP S57159738 A JPS57159738 A JP S57159738A JP 4551081 A JP4551081 A JP 4551081A JP 4551081 A JP4551081 A JP 4551081A JP S57159738 A JPS57159738 A JP S57159738A
- Authority
- JP
- Japan
- Prior art keywords
- acid derivative
- compound
- formula
- substituted
- penicillins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formulaI[Ar is substituted phenyl, naphthyl which may be substituted, or hetercyclic group; Y is hydroxyl, halogen, RO (R is group protecting carboxyl group); at least one of X1, X2 is halogen and the other is H].
EXAMPLE: 2-Dichloromethylene-2-(4-chlorophenyl) acetic acid.
USE: Modifying agent for penicillins and cephalosporins. Penicillins or cephalosporins modified therewith show strong antibacterial activity against Pseudomonas areuginosa, Myxomycetes and Escherichia coli.
PREPARATION: The reaction between aromatically substituted glyoxylic acid derivative of formula II and a Wittig's reagent such as a compound of formula III or between 2-formyl-arylacetic acid derivative of formula IV and a halogenating reagent such as POCl3 give a compound of formulaIwhere Y is OR.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4551081A JPS57159738A (en) | 1981-03-30 | 1981-03-30 | 2-halomethylene-arylacetice acid derivative |
CA000386380A CA1178947A (en) | 1980-09-26 | 1981-09-22 | .beta.-LACTAM COMPOUNDS AND PROCESS FOR THEIR PREPARATION |
EP81107575A EP0048954B1 (en) | 1980-09-26 | 1981-09-23 | Beta-lactam compounds, process for the preparation thereof and intermediate products for the preparation thereof |
DE8181107575T DE3175755D1 (en) | 1980-09-26 | 1981-09-23 | Beta-lactam compounds, process for the preparation thereof and intermediate products for the preparation thereof |
ES506440A ES506440A0 (en) | 1980-09-26 | 1981-09-23 | PROCEDURE FOR THE MANUFACTURE OF NEW B-LACTAMA COMPOUNDS |
PT73735A PT73735B (en) | 1980-09-26 | 1981-09-25 | Beta-lactam compounds process for the preparation thereof and intermediate products for the preparation thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4551081A JPS57159738A (en) | 1981-03-30 | 1981-03-30 | 2-halomethylene-arylacetice acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57159738A true JPS57159738A (en) | 1982-10-01 |
Family
ID=12721401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4551081A Pending JPS57159738A (en) | 1980-09-26 | 1981-03-30 | 2-halomethylene-arylacetice acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57159738A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6034957A (en) * | 1983-08-05 | 1985-02-22 | Meiji Seika Kaisha Ltd | 2-substituted methylene-2-(2-aminothiazol-yl)-acetic acid derivative and its preparation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
US4001301A (en) * | 1971-11-04 | 1977-01-04 | Syntex Corporation | 6-substituted 2-naphthyl acetic acid derivatives |
-
1981
- 1981-03-30 JP JP4551081A patent/JPS57159738A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
US4001301A (en) * | 1971-11-04 | 1977-01-04 | Syntex Corporation | 6-substituted 2-naphthyl acetic acid derivatives |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6034957A (en) * | 1983-08-05 | 1985-02-22 | Meiji Seika Kaisha Ltd | 2-substituted methylene-2-(2-aminothiazol-yl)-acetic acid derivative and its preparation |
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