JPS57159738A - 2-halomethylene-arylacetice acid derivative - Google Patents

2-halomethylene-arylacetice acid derivative

Info

Publication number
JPS57159738A
JPS57159738A JP4551081A JP4551081A JPS57159738A JP S57159738 A JPS57159738 A JP S57159738A JP 4551081 A JP4551081 A JP 4551081A JP 4551081 A JP4551081 A JP 4551081A JP S57159738 A JPS57159738 A JP S57159738A
Authority
JP
Japan
Prior art keywords
acid derivative
compound
formula
substituted
penicillins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4551081A
Other languages
Japanese (ja)
Inventor
Daiei Tsunemoto
Takeo Kobori
Hiromichi Kono
Sei Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP4551081A priority Critical patent/JPS57159738A/en
Priority to CA000386380A priority patent/CA1178947A/en
Priority to EP81107575A priority patent/EP0048954B1/en
Priority to DE8181107575T priority patent/DE3175755D1/en
Priority to ES506440A priority patent/ES506440A0/en
Priority to PT73735A priority patent/PT73735B/en
Publication of JPS57159738A publication Critical patent/JPS57159738A/en
Pending legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI[Ar is substituted phenyl, naphthyl which may be substituted, or hetercyclic group; Y is hydroxyl, halogen, RO (R is group protecting carboxyl group); at least one of X1, X2 is halogen and the other is H].
EXAMPLE: 2-Dichloromethylene-2-(4-chlorophenyl) acetic acid.
USE: Modifying agent for penicillins and cephalosporins. Penicillins or cephalosporins modified therewith show strong antibacterial activity against Pseudomonas areuginosa, Myxomycetes and Escherichia coli.
PREPARATION: The reaction between aromatically substituted glyoxylic acid derivative of formula II and a Wittig's reagent such as a compound of formula III or between 2-formyl-arylacetic acid derivative of formula IV and a halogenating reagent such as POCl3 give a compound of formulaIwhere Y is OR.
COPYRIGHT: (C)1982,JPO&Japio
JP4551081A 1980-09-26 1981-03-30 2-halomethylene-arylacetice acid derivative Pending JPS57159738A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP4551081A JPS57159738A (en) 1981-03-30 1981-03-30 2-halomethylene-arylacetice acid derivative
CA000386380A CA1178947A (en) 1980-09-26 1981-09-22 .beta.-LACTAM COMPOUNDS AND PROCESS FOR THEIR PREPARATION
EP81107575A EP0048954B1 (en) 1980-09-26 1981-09-23 Beta-lactam compounds, process for the preparation thereof and intermediate products for the preparation thereof
DE8181107575T DE3175755D1 (en) 1980-09-26 1981-09-23 Beta-lactam compounds, process for the preparation thereof and intermediate products for the preparation thereof
ES506440A ES506440A0 (en) 1980-09-26 1981-09-23 PROCEDURE FOR THE MANUFACTURE OF NEW B-LACTAMA COMPOUNDS
PT73735A PT73735B (en) 1980-09-26 1981-09-25 Beta-lactam compounds process for the preparation thereof and intermediate products for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4551081A JPS57159738A (en) 1981-03-30 1981-03-30 2-halomethylene-arylacetice acid derivative

Publications (1)

Publication Number Publication Date
JPS57159738A true JPS57159738A (en) 1982-10-01

Family

ID=12721401

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4551081A Pending JPS57159738A (en) 1980-09-26 1981-03-30 2-halomethylene-arylacetice acid derivative

Country Status (1)

Country Link
JP (1) JPS57159738A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034957A (en) * 1983-08-05 1985-02-22 Meiji Seika Kaisha Ltd 2-substituted methylene-2-(2-aminothiazol-yl)-acetic acid derivative and its preparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3259622A (en) * 1962-09-07 1966-07-05 Merck & Co Inc 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids
US4001301A (en) * 1971-11-04 1977-01-04 Syntex Corporation 6-substituted 2-naphthyl acetic acid derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3259622A (en) * 1962-09-07 1966-07-05 Merck & Co Inc 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids
US4001301A (en) * 1971-11-04 1977-01-04 Syntex Corporation 6-substituted 2-naphthyl acetic acid derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034957A (en) * 1983-08-05 1985-02-22 Meiji Seika Kaisha Ltd 2-substituted methylene-2-(2-aminothiazol-yl)-acetic acid derivative and its preparation

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