JPS57158722A - Antimicrobial activity enhancer and antimicrobial composition - Google Patents

Antimicrobial activity enhancer and antimicrobial composition

Info

Publication number
JPS57158722A
JPS57158722A JP4434381A JP4434381A JPS57158722A JP S57158722 A JPS57158722 A JP S57158722A JP 4434381 A JP4434381 A JP 4434381A JP 4434381 A JP4434381 A JP 4434381A JP S57158722 A JPS57158722 A JP S57158722A
Authority
JP
Japan
Prior art keywords
antimicrobial
lactam
antibiotic substance
antimicrobial activity
lactam antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4434381A
Other languages
Japanese (ja)
Other versions
JPH0243726B2 (en
Inventor
Shigeru Yamabe
Yukihiro Yasuda
Naofumi Ishida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TAIHOU YAKUHIN KOGYO KK
Taiho Pharmaceutical Co Ltd
Original Assignee
TAIHOU YAKUHIN KOGYO KK
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TAIHOU YAKUHIN KOGYO KK, Taiho Pharmaceutical Co Ltd filed Critical TAIHOU YAKUHIN KOGYO KK
Priority to JP4434381A priority Critical patent/JPS57158722A/en
Publication of JPS57158722A publication Critical patent/JPS57158722A/en
Publication of JPH0243726B2 publication Critical patent/JPH0243726B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To titled drug, containing a compound which is a synthetic intermediate for a β-lactam antibiotic substance, having the inhibitory activity against β-lactamase, and capable of synergistically enhancing the antimicrobial activity of the β-lactam antibiotic substance.
CONSTITUTION: An antimicrobial activity enhancer and an antimicrobial composition, containing a compound expressed by the formulaI(R is H or ester forming residue) or a salt thereof, and having the enhancing action on the antimicrobial activity of β-lactam antimicrobial substance, e.g. ampicillin, amoxicillin or cephaloridine. The antimicrobial activity of the β-lactam antibiotic substance sometimes is deteriorated or lost by the cleavage and decomposition of the β-lactam ring by a β-lactam decomposing enzyme, (β-lactamase), but the compound of the formula which is itself a synthetic intermediate for the β-lactam antibiotic substance, has the inhibitory activity against the β-lactamase and is capable of synergistically improving the antimicrobial activity of the β-lactam antibiotic substance by the use thereof with the β-lactam antibiotic substance. The amount of the compound to be used is usually 0.1W10mol preferably 0.5W 5mol, based on one mole antibiotic substance.
COPYRIGHT: (C)1982,JPO&Japio
JP4434381A 1981-03-25 1981-03-25 Antimicrobial activity enhancer and antimicrobial composition Granted JPS57158722A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4434381A JPS57158722A (en) 1981-03-25 1981-03-25 Antimicrobial activity enhancer and antimicrobial composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4434381A JPS57158722A (en) 1981-03-25 1981-03-25 Antimicrobial activity enhancer and antimicrobial composition

Publications (2)

Publication Number Publication Date
JPS57158722A true JPS57158722A (en) 1982-09-30
JPH0243726B2 JPH0243726B2 (en) 1990-10-01

Family

ID=12688861

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4434381A Granted JPS57158722A (en) 1981-03-25 1981-03-25 Antimicrobial activity enhancer and antimicrobial composition

Country Status (1)

Country Link
JP (1) JPS57158722A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6143116A (en) * 1984-08-03 1986-03-01 Shionogi & Co Ltd Method and agent for remedy of bacteriosis

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0481830U (en) * 1990-11-28 1992-07-16

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.MED.CHEM *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6143116A (en) * 1984-08-03 1986-03-01 Shionogi & Co Ltd Method and agent for remedy of bacteriosis

Also Published As

Publication number Publication date
JPH0243726B2 (en) 1990-10-01

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