JPS57150653A - Preparation of alpha-bromoisovalerylurea - Google Patents
Preparation of alpha-bromoisovalerylureaInfo
- Publication number
- JPS57150653A JPS57150653A JP3713481A JP3713481A JPS57150653A JP S57150653 A JPS57150653 A JP S57150653A JP 3713481 A JP3713481 A JP 3713481A JP 3713481 A JP3713481 A JP 3713481A JP S57150653 A JPS57150653 A JP S57150653A
- Authority
- JP
- Japan
- Prior art keywords
- halide
- isovaleryl
- bromoisovaleryl
- chloride
- urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate of pharmaceuticals, without using the post-treatment of the catalyst or distillation operation, etc., by reacting isovaleric acid with bromine in the presence of an isovaleryl halide, etc. to effect the αbromination, and further reacting with thionyl chloride and urea.
CONSTITUTION: Isovaleric acid is α-brominated with Br in the presence of an isovaleryl halide of α-bromoisovaleryl halide (e.g. isovaleryl chloride, isovaleryl bromide, etc.). The product is made to react with thionyl chloride to obtain α- bromoisovaleryl chloride, and the produced reaction liquid is reacted with urea in the presence of a chlorinated hydrocarbon solvent to afford the objective compound. The use of isovaleryl halide, etc. eliminates the problems of post-treatment which are inherent to the phosphorus catalyst. Since the α-bromoisovaleryl halide is an intemediate reaction product of the above process, its purification is not necessary, and the process is economical.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3713481A JPS57150653A (en) | 1981-03-13 | 1981-03-13 | Preparation of alpha-bromoisovalerylurea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3713481A JPS57150653A (en) | 1981-03-13 | 1981-03-13 | Preparation of alpha-bromoisovalerylurea |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57150653A true JPS57150653A (en) | 1982-09-17 |
| JPS6312467B2 JPS6312467B2 (en) | 1988-03-18 |
Family
ID=12489139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3713481A Granted JPS57150653A (en) | 1981-03-13 | 1981-03-13 | Preparation of alpha-bromoisovalerylurea |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57150653A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7182426B2 (en) | 2002-07-08 | 2007-02-27 | Seiko Epson Corporation | Rotor, drive conversion device, cleaning device, wiping device, and liquid injection device |
| CN108395387A (en) * | 2018-04-28 | 2018-08-14 | 苏州莱克施德药业有限公司 | A kind of synthetic method of bromisoval |
| CN110204460A (en) * | 2019-06-04 | 2019-09-06 | 华润双鹤利民药业（济南）有限公司 | A kind of bromisoval fabrication processing |
-
1981
- 1981-03-13 JP JP3713481A patent/JPS57150653A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7182426B2 (en) | 2002-07-08 | 2007-02-27 | Seiko Epson Corporation | Rotor, drive conversion device, cleaning device, wiping device, and liquid injection device |
| US7722155B2 (en) | 2002-07-08 | 2010-05-25 | Seiko Epson Corporation | Rotor, drive converting apparatus, cleaning apparatus, wiping apparatus, and liquid ejection apparatus |
| CN108395387A (en) * | 2018-04-28 | 2018-08-14 | 苏州莱克施德药业有限公司 | A kind of synthetic method of bromisoval |
| CN110204460A (en) * | 2019-06-04 | 2019-09-06 | 华润双鹤利民药业（济南）有限公司 | A kind of bromisoval fabrication processing |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6312467B2 (en) | 1988-03-18 |
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