JPS57145880A - Production of 3,3',4-tri-o-methylellagic acid - Google Patents

Production of 3,3',4-tri-o-methylellagic acid

Info

Publication number
JPS57145880A
JPS57145880A JP3129281A JP3129281A JPS57145880A JP S57145880 A JPS57145880 A JP S57145880A JP 3129281 A JP3129281 A JP 3129281A JP 3129281 A JP3129281 A JP 3129281A JP S57145880 A JPS57145880 A JP S57145880A
Authority
JP
Japan
Prior art keywords
compound
give
formula
methylated
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3129281A
Other languages
Japanese (ja)
Other versions
JPH0160030B2 (en
Inventor
Takuo Kosuge
Masami Yokota
Kunio Tsuji
Yasuo Ito
Hideo Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Japan Co Ltd
Original Assignee
Hokuriku Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Pharmaceutical Co Ltd filed Critical Hokuriku Pharmaceutical Co Ltd
Priority to JP3129281A priority Critical patent/JPS57145880A/en
Publication of JPS57145880A publication Critical patent/JPS57145880A/en
Publication of JPH0160030B2 publication Critical patent/JPH0160030B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: One of two acetyl groups in 4,4'-di-O-acetyl-3,3'-di-O-methylellagic acid is specifically removed under specific conditions; the product is methylated and hydrolyzed to give the titled compound used as a styptic in high yield.
CONSTITUTION: The compound of formula IV is subjected to specific removal of one of the acetyl groups in the presence of dimethylformamide and aniline to give the compound of formula V. The product is methylated with a reagent such as dimethyl sulfate, diazomethane or methyl iodide to give the compound of formula III. Further, it is hydrolzyed with an alkali to give the compound of formulaI. The process of the present invention gives the compound of formulaIin a yield as high as 5 times that when it is produced by the conventional one, i.e., using the compound of formula II as a starting material to effect methylation and hydrolysis, thus being industrially advantageous.
COPYRIGHT: (C)1982,JPO&Japio
JP3129281A 1981-03-06 1981-03-06 Production of 3,3',4-tri-o-methylellagic acid Granted JPS57145880A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3129281A JPS57145880A (en) 1981-03-06 1981-03-06 Production of 3,3',4-tri-o-methylellagic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3129281A JPS57145880A (en) 1981-03-06 1981-03-06 Production of 3,3',4-tri-o-methylellagic acid

Publications (2)

Publication Number Publication Date
JPS57145880A true JPS57145880A (en) 1982-09-09
JPH0160030B2 JPH0160030B2 (en) 1989-12-20

Family

ID=12327226

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3129281A Granted JPS57145880A (en) 1981-03-06 1981-03-06 Production of 3,3',4-tri-o-methylellagic acid

Country Status (1)

Country Link
JP (1) JPS57145880A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073545A (en) * 1987-06-09 1991-12-17 Lion Corporation Agent containing an ellagic acid series compound for external application and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073545A (en) * 1987-06-09 1991-12-17 Lion Corporation Agent containing an ellagic acid series compound for external application and use thereof

Also Published As

Publication number Publication date
JPH0160030B2 (en) 1989-12-20

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