JPS57144279A - Dihydro ml-236b and dihydro mb-530b and derivative thereof - Google Patents

Dihydro ml-236b and dihydro mb-530b and derivative thereof

Info

Publication number
JPS57144279A
JPS57144279A JP2954881A JP2954881A JPS57144279A JP S57144279 A JPS57144279 A JP S57144279A JP 2954881 A JP2954881 A JP 2954881A JP 2954881 A JP2954881 A JP 2954881A JP S57144279 A JPS57144279 A JP S57144279A
Authority
JP
Japan
Prior art keywords
dihydro
expressed
formula
metallic
formulai
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2954881A
Other languages
Japanese (ja)
Other versions
JPH0115493B2 (en
Inventor
Kunio Nakano
Akira Ogiso
Akira Terahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP2954881A priority Critical patent/JPS57144279A/en
Publication of JPS57144279A publication Critical patent/JPS57144279A/en
Publication of JPH0115493B2 publication Critical patent/JPH0115493B2/ja
Granted legal-status Critical Current

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  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:Dihydro ML-236B and dihydro MB-530B expressed by formulaI(R1 is H or methyl), metallic carboxylate thereof expressed by formula II (M is metallic element; n is valence), amino acid salt and amine salt of carboxylic acid thereof expressed by formula III (A is amino acid or organic amine) and carboxylic ester thereof expressed by formula IV (R2 is alkyl, etc.).
USE: A remedy for hyperlipemia and preventing agent for arteriosclerosis.
PROCESS: ML-236B or MB-530B is dissolved in a solvent, e.g. methanol or ethanol, and then hydrogenated in the presence of a catalyst, e.g. palladium catalyst, to give the compound of formulaI. The compound of formula II is obtained by catalytically hydrogenating a metallic carboxylate of ML-236B or metallic carboxylate of MB-530B in the same way without advancing the reduction to further than the dihydro derivative.
COPYRIGHT: (C)1982,JPO&Japio
JP2954881A 1981-03-02 1981-03-02 Dihydro ml-236b and dihydro mb-530b and derivative thereof Granted JPS57144279A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2954881A JPS57144279A (en) 1981-03-02 1981-03-02 Dihydro ml-236b and dihydro mb-530b and derivative thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2954881A JPS57144279A (en) 1981-03-02 1981-03-02 Dihydro ml-236b and dihydro mb-530b and derivative thereof

Publications (2)

Publication Number Publication Date
JPS57144279A true JPS57144279A (en) 1982-09-06
JPH0115493B2 JPH0115493B2 (en) 1989-03-17

Family

ID=12279181

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2954881A Granted JPS57144279A (en) 1981-03-02 1981-03-02 Dihydro ml-236b and dihydro mb-530b and derivative thereof

Country Status (1)

Country Link
JP (1) JPS57144279A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272174A (en) * 1985-09-13 1993-12-21 Sankyo Company, Limited Hydroxy-ML-236B derivatives, their preparation and use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568689A (en) * 1979-06-15 1981-01-29 Merck & Co Inc Low cholesterine blood desease fermentation product and production thereof
JPS57122076A (en) * 1980-11-17 1982-07-29 Merck & Co Inc Hypocholesterolemic fermentation product and manufacture

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568689A (en) * 1979-06-15 1981-01-29 Merck & Co Inc Low cholesterine blood desease fermentation product and production thereof
JPS57122076A (en) * 1980-11-17 1982-07-29 Merck & Co Inc Hypocholesterolemic fermentation product and manufacture

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272174A (en) * 1985-09-13 1993-12-21 Sankyo Company, Limited Hydroxy-ML-236B derivatives, their preparation and use

Also Published As

Publication number Publication date
JPH0115493B2 (en) 1989-03-17

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