JPS57149247A - Trans tetrahydro ml-236b and its derivative - Google Patents
Trans tetrahydro ml-236b and its derivativeInfo
- Publication number
- JPS57149247A JPS57149247A JP3492881A JP3492881A JPS57149247A JP S57149247 A JPS57149247 A JP S57149247A JP 3492881 A JP3492881 A JP 3492881A JP 3492881 A JP3492881 A JP 3492881A JP S57149247 A JPS57149247 A JP S57149247A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- formulai
- alkyl
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A trans tetrahydro ML-236B shown by the formulaI{R1 is a group shown by the formula IIWformula IV[R2 is H, alkyl, benzyl or phenacryl capable of having substituent group (alkyl, alkoxy, halogen), 1/n.M (M is metal atom; n is velence of M); A is amino acid, organic amine]} and its derivative.
USE: A chloresterol synthesis inhibitor having further improved effect than a cis form.
PROCESS: ML-236B is hydrogenated in a solvent such as methanol, ethanol, isopropanol, tetrahydrofuran, etc. in the presence of Raney nickel or palladium catalyst at room temperature W60°C preferably at a hydrogen pressure of 3W 4kg/cm2, to give a compound shown by the formulaI(R1=a group shown by the formula II).
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3492881A JPS57149247A (en) | 1981-03-11 | 1981-03-11 | Trans tetrahydro ml-236b and its derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3492881A JPS57149247A (en) | 1981-03-11 | 1981-03-11 | Trans tetrahydro ml-236b and its derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57149247A true JPS57149247A (en) | 1982-09-14 |
Family
ID=12427853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3492881A Pending JPS57149247A (en) | 1981-03-11 | 1981-03-11 | Trans tetrahydro ml-236b and its derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57149247A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582915A (en) * | 1983-10-11 | 1986-04-15 | Merck & Co., Inc. | Process for C-methylation of 2-methylbutyrates |
| US4584389A (en) * | 1983-10-11 | 1986-04-22 | Merck & Co., Inc. | Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS559024A (en) * | 1978-07-04 | 1980-01-22 | Sankyo Co Ltd | Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent |
-
1981
- 1981-03-11 JP JP3492881A patent/JPS57149247A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS559024A (en) * | 1978-07-04 | 1980-01-22 | Sankyo Co Ltd | Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582915A (en) * | 1983-10-11 | 1986-04-15 | Merck & Co., Inc. | Process for C-methylation of 2-methylbutyrates |
| US4584389A (en) * | 1983-10-11 | 1986-04-22 | Merck & Co., Inc. | Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one |
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