JPS57131788A - 1,7-naphthyridine derivative - Google Patents
1,7-naphthyridine derivativeInfo
- Publication number
- JPS57131788A JPS57131788A JP56004766A JP476681A JPS57131788A JP S57131788 A JPS57131788 A JP S57131788A JP 56004766 A JP56004766 A JP 56004766A JP 476681 A JP476681 A JP 476681A JP S57131788 A JPS57131788 A JP S57131788A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- reacted
- afford
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A 1,7-naphthyridine derivative of formula 1 (R is lower alkyl) and a salt thereof.
EXAMPLE: 5-( 3-Ethylamino-2-hydroxypropoxy )-1,2,3,4-tetrahydro-1,7-naphthyridin- 2-one.
USE: Useful as a preventing agent and a remedy for angina pectoris, arrhythmia and thrombosis and a hypotensive agent having β-adrenergic blocking action and inhibitory action on blood platelet aggregation.
PROCESS: A compound of formula 2 is reacted with a compound of formula 3 (R1 is lower alkanoyl; R2 is lower phenylalkyl) is reacted with a compound of formula 3 (X1 is halogen) in a suitable solvent at 100W150°C to give a compound of formula 4, which is then dehydrogenated and reacted with an alkali metal to afford a compound of formula 7. The resultant compound of formula 7 is then reacted with a compound of formula 8 (X2 is X1) to give a compound of formula 9 (Y is formula 11 or 12), which is then reacted with an amine of the formula RNH2 to afford the compound of formula 1.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56004766A JPS57131788A (en) | 1981-01-13 | 1981-01-13 | 1,7-naphthyridine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56004766A JPS57131788A (en) | 1981-01-13 | 1981-01-13 | 1,7-naphthyridine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57131788A true JPS57131788A (en) | 1982-08-14 |
Family
ID=11592981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56004766A Pending JPS57131788A (en) | 1981-01-13 | 1981-01-13 | 1,7-naphthyridine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57131788A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55118432A (en) * | 1979-03-07 | 1980-09-11 | Shionogi & Co Ltd | 2-spipo-1,3-dioxolane compound and new synthesis of aromatic ether by its ring opening reaction |
-
1981
- 1981-01-13 JP JP56004766A patent/JPS57131788A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55118432A (en) * | 1979-03-07 | 1980-09-11 | Shionogi & Co Ltd | 2-spipo-1,3-dioxolane compound and new synthesis of aromatic ether by its ring opening reaction |
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