JPS57131788A - 1,7-naphthyridine derivative - Google Patents

1,7-naphthyridine derivative

Info

Publication number
JPS57131788A
JPS57131788A JP56004766A JP476681A JPS57131788A JP S57131788 A JPS57131788 A JP S57131788A JP 56004766 A JP56004766 A JP 56004766A JP 476681 A JP476681 A JP 476681A JP S57131788 A JPS57131788 A JP S57131788A
Authority
JP
Japan
Prior art keywords
formula
compound
reacted
afford
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56004766A
Other languages
Japanese (ja)
Inventor
Yasumitsu Tamura
Rinkei Chin
Masanobu Fujita
Yasuyuki Kita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP56004766A priority Critical patent/JPS57131788A/en
Publication of JPS57131788A publication Critical patent/JPS57131788A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 1,7-naphthyridine derivative of formula 1 (R is lower alkyl) and a salt thereof.
EXAMPLE: 5-( 3-Ethylamino-2-hydroxypropoxy )-1,2,3,4-tetrahydro-1,7-naphthyridin- 2-one.
USE: Useful as a preventing agent and a remedy for angina pectoris, arrhythmia and thrombosis and a hypotensive agent having β-adrenergic blocking action and inhibitory action on blood platelet aggregation.
PROCESS: A compound of formula 2 is reacted with a compound of formula 3 (R1 is lower alkanoyl; R2 is lower phenylalkyl) is reacted with a compound of formula 3 (X1 is halogen) in a suitable solvent at 100W150°C to give a compound of formula 4, which is then dehydrogenated and reacted with an alkali metal to afford a compound of formula 7. The resultant compound of formula 7 is then reacted with a compound of formula 8 (X2 is X1) to give a compound of formula 9 (Y is formula 11 or 12), which is then reacted with an amine of the formula RNH2 to afford the compound of formula 1.
COPYRIGHT: (C)1982,JPO&Japio
JP56004766A 1981-01-13 1981-01-13 1,7-naphthyridine derivative Pending JPS57131788A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56004766A JPS57131788A (en) 1981-01-13 1981-01-13 1,7-naphthyridine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56004766A JPS57131788A (en) 1981-01-13 1981-01-13 1,7-naphthyridine derivative

Publications (1)

Publication Number Publication Date
JPS57131788A true JPS57131788A (en) 1982-08-14

Family

ID=11592981

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56004766A Pending JPS57131788A (en) 1981-01-13 1981-01-13 1,7-naphthyridine derivative

Country Status (1)

Country Link
JP (1) JPS57131788A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55118432A (en) * 1979-03-07 1980-09-11 Shionogi & Co Ltd 2-spipo-1,3-dioxolane compound and new synthesis of aromatic ether by its ring opening reaction

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55118432A (en) * 1979-03-07 1980-09-11 Shionogi & Co Ltd 2-spipo-1,3-dioxolane compound and new synthesis of aromatic ether by its ring opening reaction

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