FR2312244A1 - Hypoglycaemic 2-imidazolines - e.g. (2-(6-fluoro 1,2,3,4-tetrahydro 1-naphthyl methyl) imidazoline - Google Patents
Hypoglycaemic 2-imidazolines - e.g. (2-(6-fluoro 1,2,3,4-tetrahydro 1-naphthyl methyl) imidazolineInfo
- Publication number
- FR2312244A1 FR2312244A1 FR7615831A FR7615831A FR2312244A1 FR 2312244 A1 FR2312244 A1 FR 2312244A1 FR 7615831 A FR7615831 A FR 7615831A FR 7615831 A FR7615831 A FR 7615831A FR 2312244 A1 FR2312244 A1 FR 2312244A1
- Authority
- FR
- France
- Prior art keywords
- imidazolines
- hypoglycaemic
- imidazoline
- tetrahydro
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Novel imidazolines of formula (I) and their acid-addn. salts: (where X and Y are H or F; R and R1 are H or 1-6C alkyl or 3-6C cycloalkyl; and n is 1-3) are hypoglycaemic agents, used at a dose of 1-6 mg/kg.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58231275A | 1975-05-30 | 1975-05-30 | |
US05/582,313 US3992403A (en) | 1975-05-30 | 1975-05-30 | 2-Imidazolines and their use as hypoglycemic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2312244A1 true FR2312244A1 (en) | 1976-12-24 |
FR2312244B1 FR2312244B1 (en) | 1979-09-21 |
Family
ID=27078537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7615831A Granted FR2312244A1 (en) | 1975-05-30 | 1976-05-25 | Hypoglycaemic 2-imidazolines - e.g. (2-(6-fluoro 1,2,3,4-tetrahydro 1-naphthyl methyl) imidazoline |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS51143668A (en) |
AU (1) | AU1432676A (en) |
DE (1) | DE2623377A1 (en) |
DK (1) | DK229376A (en) |
FR (1) | FR2312244A1 (en) |
IL (1) | IL49664A0 (en) |
LU (1) | LU75035A1 (en) |
NL (1) | NL7605609A (en) |
SE (1) | SE7605958L (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0064820A1 (en) * | 1981-04-22 | 1982-11-17 | Farmos-Yhtyma Oy | Substituted imidazole and imidazoline derivatives and their preparation and use |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4201709A1 (en) * | 1992-01-23 | 1993-07-29 | Bayer Ag | (ALPHA) -aryl- (ALPHA) -hydroxy-SS-imidazolinyl-propionamides |
US6410562B1 (en) | 1998-12-18 | 2002-06-25 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
AU2007209382A1 (en) * | 2006-01-27 | 2007-08-02 | F. Hoffmann-La Roche Ag | Use of 2-imidazoles for the treatment of CNS disorders |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2919274A (en) * | 1957-09-17 | 1959-12-29 | Sahyun Melville | Amidines |
GB877306A (en) * | 1958-04-21 | 1961-09-13 | Pfizer & Co C | Halogenated derivatives of tetrahydro-1-naphthyl cyclic amidines |
FR2208663A1 (en) * | 1972-11-30 | 1974-06-28 | Hexachimie |
-
1976
- 1976-05-25 DK DK229376A patent/DK229376A/en unknown
- 1976-05-25 DE DE19762623377 patent/DE2623377A1/en active Pending
- 1976-05-25 SE SE7605958*7A patent/SE7605958L/en unknown
- 1976-05-25 JP JP51060543A patent/JPS51143668A/en active Pending
- 1976-05-25 NL NL7605609A patent/NL7605609A/en unknown
- 1976-05-25 FR FR7615831A patent/FR2312244A1/en active Granted
- 1976-05-26 AU AU14326/76A patent/AU1432676A/en not_active Expired
- 1976-05-26 IL IL49664A patent/IL49664A0/en unknown
- 1976-05-26 LU LU75035A patent/LU75035A1/xx unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2919274A (en) * | 1957-09-17 | 1959-12-29 | Sahyun Melville | Amidines |
GB877306A (en) * | 1958-04-21 | 1961-09-13 | Pfizer & Co C | Halogenated derivatives of tetrahydro-1-naphthyl cyclic amidines |
FR2208663A1 (en) * | 1972-11-30 | 1974-06-28 | Hexachimie |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0064820A1 (en) * | 1981-04-22 | 1982-11-17 | Farmos-Yhtyma Oy | Substituted imidazole and imidazoline derivatives and their preparation and use |
Also Published As
Publication number | Publication date |
---|---|
NL7605609A (en) | 1976-12-02 |
FR2312244B1 (en) | 1979-09-21 |
SE7605958L (en) | 1976-12-01 |
IL49664A0 (en) | 1976-07-30 |
LU75035A1 (en) | 1977-02-15 |
JPS51143668A (en) | 1976-12-10 |
DK229376A (en) | 1976-12-01 |
AU1432676A (en) | 1977-12-01 |
DE2623377A1 (en) | 1976-12-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |