JPS57108065A - 7-thiaprostaglandin e1 derivative, its preparation, and blood platelet coagulation inhibiting agent containing said derivative as active component - Google Patents
7-thiaprostaglandin e1 derivative, its preparation, and blood platelet coagulation inhibiting agent containing said derivative as active componentInfo
- Publication number
- JPS57108065A JPS57108065A JP55183727A JP18372780A JPS57108065A JP S57108065 A JPS57108065 A JP S57108065A JP 55183727 A JP55183727 A JP 55183727A JP 18372780 A JP18372780 A JP 18372780A JP S57108065 A JPS57108065 A JP S57108065A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- thiaprostaglandin
- protecting group
- inhibiting agent
- blood platelet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001772 blood platelet Anatomy 0.000 title abstract 2
- 230000015271 coagulation Effects 0.000 title abstract 2
- 238000005345 coagulation Methods 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- OPHUWKNKFYBPDR-UHFFFAOYSA-N copper lithium Chemical compound [Li].[Cu] OPHUWKNKFYBPDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55183727A JPS57108065A (en) | 1980-12-26 | 1980-12-26 | 7-thiaprostaglandin e1 derivative, its preparation, and blood platelet coagulation inhibiting agent containing said derivative as active component |
| DE8181109250T DE3168199D1 (en) | 1980-10-31 | 1981-10-29 | Novel thiaprostaglandin e1 derivatives, process for production thereof, and pharmaceuticals containing these compounds |
| EP81109250A EP0051284B1 (en) | 1980-10-31 | 1981-10-29 | Novel thiaprostaglandin e1 derivatives, process for production thereof, and pharmaceuticals containing these compounds |
| US06/316,902 US4466980A (en) | 1980-10-31 | 1981-10-30 | Thiaprostaglandin E1 derivatives, process for production thereof, and pharmaceutical use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55183727A JPS57108065A (en) | 1980-12-26 | 1980-12-26 | 7-thiaprostaglandin e1 derivative, its preparation, and blood platelet coagulation inhibiting agent containing said derivative as active component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57108065A true JPS57108065A (en) | 1982-07-05 |
| JPH0123445B2 JPH0123445B2 (enrdf_load_stackoverflow) | 1989-05-02 |
Family
ID=16140901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55183727A Granted JPS57108065A (en) | 1980-10-31 | 1980-12-26 | 7-thiaprostaglandin e1 derivative, its preparation, and blood platelet coagulation inhibiting agent containing said derivative as active component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57108065A (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5929661A (ja) * | 1982-08-12 | 1984-02-16 | Teijin Ltd | 7−チアプロスタグランジンe↓1類およびその製造法並びにそれを有効成分とする血小板凝集阻止剤 |
| WO1985003936A1 (en) * | 1984-03-05 | 1985-09-12 | Teijin Limited | 7-thiaprostaglandin e1's and process for their preparation |
| JPS60185761A (ja) * | 1984-03-05 | 1985-09-21 | Teijin Ltd | 7−チアプロスタグランジンe↓1類およびその製造法 |
| US5159102A (en) * | 1984-03-05 | 1992-10-27 | Teijin Limited | 7-thiaprostaglandins E, and process for producing same |
| US5892099A (en) * | 1997-01-27 | 1999-04-06 | Ono Pharmaceutical Co., Ltd. | 3,7-dithiaprostanoic acid derivative |
| US6043275A (en) * | 1998-04-16 | 2000-03-28 | Ono Pharmaceutical Co., Ltd. | 3,7-dithiaprostanoic acid derivative |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5368753A (en) * | 1976-12-01 | 1978-06-19 | Teijin Ltd | Thiaprostanoic acid derivatives and their preparation |
| JPS53127832A (en) * | 1977-04-11 | 1978-11-08 | Teijin Ltd | Antiphkogistics for oral administration containing thiaprostaglandins |
-
1980
- 1980-12-26 JP JP55183727A patent/JPS57108065A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5368753A (en) * | 1976-12-01 | 1978-06-19 | Teijin Ltd | Thiaprostanoic acid derivatives and their preparation |
| JPS53127832A (en) * | 1977-04-11 | 1978-11-08 | Teijin Ltd | Antiphkogistics for oral administration containing thiaprostaglandins |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5929661A (ja) * | 1982-08-12 | 1984-02-16 | Teijin Ltd | 7−チアプロスタグランジンe↓1類およびその製造法並びにそれを有効成分とする血小板凝集阻止剤 |
| WO1985003936A1 (en) * | 1984-03-05 | 1985-09-12 | Teijin Limited | 7-thiaprostaglandin e1's and process for their preparation |
| JPS60185761A (ja) * | 1984-03-05 | 1985-09-21 | Teijin Ltd | 7−チアプロスタグランジンe↓1類およびその製造法 |
| US5159102A (en) * | 1984-03-05 | 1992-10-27 | Teijin Limited | 7-thiaprostaglandins E, and process for producing same |
| US5892099A (en) * | 1997-01-27 | 1999-04-06 | Ono Pharmaceutical Co., Ltd. | 3,7-dithiaprostanoic acid derivative |
| US6043275A (en) * | 1998-04-16 | 2000-03-28 | Ono Pharmaceutical Co., Ltd. | 3,7-dithiaprostanoic acid derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0123445B2 (enrdf_load_stackoverflow) | 1989-05-02 |
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