JPS57106614A - Preparation of prolonged release type composite - Google Patents

Preparation of prolonged release type composite

Info

Publication number
JPS57106614A
JPS57106614A JP18153080A JP18153080A JPS57106614A JP S57106614 A JPS57106614 A JP S57106614A JP 18153080 A JP18153080 A JP 18153080A JP 18153080 A JP18153080 A JP 18153080A JP S57106614 A JPS57106614 A JP S57106614A
Authority
JP
Japan
Prior art keywords
prolonged release
type composite
release type
powdery
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18153080A
Other languages
Japanese (ja)
Inventor
Masaharu Asano
Masaru Yoshida
Isao Kaetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Agency
Original Assignee
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON GENSHIRYOKU KENKYUSHO, Japan Atomic Energy Research Institute filed Critical NIPPON GENSHIRYOKU KENKYUSHO
Priority to JP18153080A priority Critical patent/JPS57106614A/en
Publication of JPS57106614A publication Critical patent/JPS57106614A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To obtain a prolonged release type composite having improved prolonged release properties and the desired shape, by mixing a powdery polypeptid with a powdery physiologically active substance, and treating the resultant mixture under pressure.
CONSTITUTION: A powdery polypeptide, e.g. poly-alanine or polyglycine, is mixed with a physiologically active substance, e.g. beomycin drochloride, growth hormone, or antihistaminic agent, and the resultant mixture is then treated under a pressure of 50W20,000kg/cm2 to give the aimed prolonged release type composite of desired shape. According to the method, the polypeptide becomes a film in appearance, and the physiologically active substance is uniformly dispersed and covered with the film-like polypeptide to give the prolonged release type composite having a long duration of drug effects. The two components must be finely pulverized prior to the mixing thereof, e.g. by a method of pulverizing the components in a forzen state at -190°C (liquid nitrogen temperature).
COPYRIGHT: (C)1982,JPO&Japio
JP18153080A 1980-12-22 1980-12-22 Preparation of prolonged release type composite Pending JPS57106614A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18153080A JPS57106614A (en) 1980-12-22 1980-12-22 Preparation of prolonged release type composite

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18153080A JPS57106614A (en) 1980-12-22 1980-12-22 Preparation of prolonged release type composite

Publications (1)

Publication Number Publication Date
JPS57106614A true JPS57106614A (en) 1982-07-02

Family

ID=16102372

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18153080A Pending JPS57106614A (en) 1980-12-22 1980-12-22 Preparation of prolonged release type composite

Country Status (1)

Country Link
JP (1) JPS57106614A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4842604A (en) * 1985-02-19 1989-06-27 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4842604A (en) * 1985-02-19 1989-06-27 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics

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